scholarly journals A phase II study of the modulation of 5-fluorouracil and folinic acid with high-dose infusional hydroxyurea in metastatic colorectal carcinoma

1999 ◽  
Vol 10 (8) ◽  
pp. 981-983 ◽  
Author(s):  
K.J. O'Byrne ◽  
P.A. Philip ◽  
D.J. Propper ◽  
I.P. Braybrooke ◽  
M.P. Saunders ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Folinic Acid ◽  
Phase Ii ◽  
Phase Ii Study ◽  
High Dose ◽  
Metastatic Colorectal Carcinoma

A phase II study of chemotherapy of metastatic colorectal carcinoma with 5-fluorouracil plus cisplatin

1991 ◽  
Vol 9 (4) ◽  
Author(s):  
RobertP. Whitehead ◽  
ThomasR. Fleming ◽  
JohnS. Macdonald ◽  
FrederickR. Ahmann ◽  
HarinderS. Garewal ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Phase Ii ◽  
Phase Ii Study ◽  
Metastatic Colorectal Carcinoma

Serum Uric Acid and C-reactive Protein in Patients with Metastatic Colorectal Carcinoma During Combination Therapy with High-dose Folinic Acid

Pteridines ◽  
2012 ◽  
Vol 23 (1) ◽  
pp. 8-13
Author(s):  
Bohuslav Melichar ◽  
Radomír Hyšpler ◽  
Hana Kalábová ◽  
Petra Holecková ◽  
Hana Študentová
Keyword(s):  
Uric Acid ◽  
Colorectal Carcinoma ◽  
Combination Therapy ◽  
Folinic Acid ◽  
Serum Uric Acid ◽  
Rank Test ◽  
High Dose ◽  
Metastatic Colorectal Carcinoma ◽  
Increased Risk ◽  
Serum Crp

Abstract New spectrum of side effects has emerged with the introduction of targeted therapies, including changes in parameters determining cardiovascular risk. Among other laboratory parameters, hyperuricemia and elevated Creactive protein (CRP) are associated with increased risk of cardiovascular disease. The aim of the present study was to investigate the changes of serum uric acid and CRP during the therapy with cetuximab, combined with 5- fluorouracil and high-dose folinic acid, in patients with metastatic colorectal carcinoma and the association of these changes with the outcome of the therapy. CRP and uric acid were determined using particle-enhanced immunoturbidimetric assay and uricase method, respectively. Measurements before and during the treatment were compared by Wilcoxon signed rank test, and comparison between survivors and non-survivors was performed by Mann-Whitney U test. Compared to baseline (pre-treatment) concentrations, serum uric acid was decreased significantly throughout the course of the combination treatment with irinotecan, 5-fluorouracil, highdose folinic acid and cetuximab. The decrease was evident early in the course of treatment. Serum CRP was also decreased significantly throughout the most of the course of therapy. The significant decrease of serum uric acid and CRP was evident already one week after the start of treatment. Serum CRP was significantly lower in patients who survived 12 months, but no difference of uric acid concentrations between survivors and non-survivors was found. A marked decrease of serum uric acid was observed during the combination therapy. High CRP was associated with poor prognosis, but no association between uric acid and prognosis was noted.

A Randomised Phase II Study of Irinotecan in Combination with 5-FU/FA Compared with Irinotecan Alone as Second-Line Treatment of Patients with Metastatic Colorectal Carcinoma

2007 ◽  
Vol 30 (4) ◽  
pp. 169-174 ◽  
Author(s):  
Ullrich Graeven ◽  
Dirk Arnold ◽  
Anke Reinacher-Schick ◽  
Theodor Heuer ◽  
Arnd Nusch ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Phase Ii ◽  
Phase Ii Study ◽  
Line Treatment ◽  
Second Line ◽  
Metastatic Colorectal Carcinoma

scholarly journals A phase II study of chloroquinoxaline sulfonamide (CQS) in patients with metastatic colorectal carcinoma (MCRC)

2006 ◽  
Author(s):  
Tanios S. Bekaii-Saab ◽  
Amir Mortazavi ◽  
Lee G. Hicks ◽  
Mark Zalupski ◽  
Robert J. Pelley ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Phase Ii ◽  
Phase Ii Study ◽  
Metastatic Colorectal Carcinoma ◽  
Chloroquinoxaline Sulfonamide

scholarly journals Phase II study of weekly 24-hour intra-arterial high-dose infusion of 5-fluorouracil and folinic acid for liver metastases from colorectal carcinomas

2001 ◽  
Vol 12 (3) ◽  
pp. 321-325 ◽  
Author(s):  
M. Lorenz ◽  
H.H. Mueller ◽  
E. Mattes ◽  
H.J. Gassel ◽  
T. Junginger ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Folinic Acid ◽  
Phase Ii ◽  
Phase Ii Study ◽  
High Dose ◽  
Colorectal Carcinomas ◽  
Dose Infusion

A Phase II Study of 5-Fluorouracil Plus High-Dose Folinic Acid in the Treatment of Recurrent Small Cell Lung Cancer

1995 ◽  
Vol 18 (2) ◽  
pp. 130-132 ◽  
Author(s):  
David J. Stewart ◽  
Simone Dahrouge ◽  
Katherine M. Soltys ◽  
William K. Evans
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Folinic Acid ◽  
Phase Ii ◽  
Cell Lung Cancer ◽  
Phase Ii Study ◽  
Small Cell ◽  
High Dose ◽  
Small Cell Lung
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