The response of skin perfusion and of rheological and immunological variables to intravenous prostanoid administration in Raynaud’s phenomenon secondary to collagenosis

VASA ◽  
2005 ◽  
Vol 34 (4) ◽  
pp. 243-249 ◽  
Author(s):  
Drinda ◽  
Neumann ◽  
Pöhlmann ◽  
Vogelsang ◽  
Stein ◽  
...  
Keyword(s):  
Laser Doppler Flowmetry ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Plasma Viscosity ◽  
Laser Doppler ◽  
Erythrocyte Aggregation ◽  
Control Group ◽  
Long Term Effects ◽  
Doppler Flowmetry

Background: Prostanoids are used in the treatment of Raynaud’s phenomenon and acral perfusion disorders secondary to collagenosis. In subjective terms, intravenous administration of these agents produces success in more than 50% of patients. The therapeutic outcome of clinical administration of alprostadil or iloprost may vary from individual to individual. Patients and methods: The following variables were analysed in a cross-over study in 27 patients with collagenosis and Raynaud’s phenomenon: plasma viscosity and erythrocyte aggregation (rheological variables), partial pressure of oxygen and laser Doppler flowmetry in the finger region, and lymphocyte phenotyping and interleukin (IL) determinations (immunological variables). Results: Laser Doppler flowmetry revealed significant differences between patients with secondary Raynaud’s phenomenon and a control group of 25 healthy subjects. Laser Doppler readings did not change significantly as a result of the treatments. Therapy with iloprost produced a reduction in IL-1beta, L-selectin (CD 62 L) and IL-6. Conclusion: The change in immunological variables due to iloprost may explain the long-term effects of prostaglandins in the treatment of Raynaud’s phenomenon. From our results it is not possible to infer any preference for iloprost or alprostadil.

scholarly journals Efficacy of Laser Doppler Flowmetry, as a Diagnostic Tool in Assessing Pulp Vitality of Traumatised Teeth. A Split Mouth Clinical Study

2021 ◽  
Vol 11 (8) ◽  
pp. 801
Author(s):  
Ani Belcheva ◽  
Maria Shindova ◽  
Reem Hanna
Keyword(s):  
Laser Doppler Flowmetry ◽  
Test Group ◽  
Laser Doppler ◽  
Permanent Teeth ◽  
Control Group ◽  
Eligibility Criteria ◽  
Doppler Flowmetry ◽  
Registration Number ◽  
Pulp Vitality ◽  
And Control

Aim: This study aimed to evaluate the efficacy of laser Doppler flowmetry (LDF) in determining the changes in the pulpal blood flow (PBF) during post-traumatic period of the traumatised permanent teeth. Methods: 88 teeth of 44 patients (mean age 10.30 ± 2.38) were recruited according to the eligibility criteria and divided into two groups: test group (44 traumatised teeth) and control group (44 sound and healthy teeth). The measurement of PBF was performed, using a LDF monitor. Results: The analysis of the LDF outcomes in function of diagnosis indicated that the measurements of the traumatised teeth were significantly higher than those of non-traumatised teeth (p ˂ 0.05). Conclusions: LDF application provides dentists with fundamental benefits in terms of an early and precise investigation of PBF. In addition, LDF is a useful monitoring tool for revascularization of traumatised teeth and reliable objective diagnostic indicator of pulp vitality. Trial registration: ClinicalTrials.gov (Registration number: NCT04967456).

scholarly journals Diagnostic capabilities of different methods of laser doppler flowmetry spectral indexes assessment in patients with diabetic microangiopathy

2021 ◽  
Vol 10 (2) ◽  
pp. 18-24
Author(s):  
P. V. Vasilev ◽  
N. P. Erofeev ◽  
A. N. Shishkin
Keyword(s):  
Diabetes Mellitus ◽  
Laser Doppler Flowmetry ◽  
Main Group ◽  
Laser Doppler ◽  
Diabetic Microangiopathy ◽  
Control Group ◽  
Spectral Parameters ◽  
Doppler Flowmetry ◽  
Diagnostic Capabilities ◽  
And Control

The article contains the results of a study of two different methods for calculating the spectral parameters of laser Doppler flowmetry in patients with diabetic microangiopathy caused by type 2 diabetes mellitus (main group) and those with excluded diabetes mellitus (control group). Spectral indices were calculated using either average or maximum amplitudes of the frequency ranges. When comparing the contribution of respiratory and pulse fluxmotions using average amplitudes, there were significant (p < 0.05) differences between the main and control groups. On the contrary, when using the maximum amplitudes, no significant differences were noted (p > 0.05). Also, significant correlations were found between the contributions of respiratory and pulse fluxmotions and the estimated glomerular filtration rate in the main group, using both calculation methods. These studies indicate the feasibility of using a technique based on the analysis of average amplitudes to increase the specificity of laser Doppler flowmetry as a method for diagnosing diabetic microangiopathy.

scholarly journals Postocclusive Hyperemia Measured with Laser Doppler Flowmetry and Transcutaneous Oxygen Tension in the Diagnosis of Primary Raynaud’s Phenomenon: A Prospective, Controlled Study

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Paweł Maga ◽  
Brandon Michael Henry ◽  
Elizabeth K. Kmiotek ◽  
Iwona Gregorczyk-Maga ◽  
Paweł Kaczmarczyk ◽  
...  
Keyword(s):  
Blood Flow ◽  
Oxygen Tension ◽  
Laser Doppler Flowmetry ◽  
Peak Flow ◽  
Raynaud’S Phenomenon ◽  
Laser Doppler ◽  
Transcutaneous Oxygen Tension ◽  
Transcutaneous Oxygen ◽  
Doppler Flowmetry ◽  
Primary Raynaud’S Phenomenon

The aim of this study was to measure the sensitivity and specificity of transcutaneous oxygen tension and postocclusive hyperemia testing using laser Doppler flowmetry in patients with primary Raynaud’s phenomenon. One hundred patients and one hundred controls were included in the study. Baseline microvascular blood flow and then time to peak flow following occlusion were measured using laser Doppler flowmetry. Afterwards, the transcutaneous oxygen tension was recorded. The sensitivities of baseline microvascular blood flow, postocclusive time to peak flow, and transcutaneous oxygen tension were 79%, 79%, and 77%, respectively. The postocclusive time peak flow had a superior specificity of 90% and area under the curve of 0.92 as compared to 66% and 0.80 for baseline microvascular flow and 64% and 0.76 for transcutaneous oxygen tension. Time to postocclusive peak blood flow measured by laser Doppler flowmetry is a highly accurate test for differentiating patients with primary Raynaud’s phenomenon from healthy controls.

Estimation of non-linear dynamic processes and oscillating circuit of microcirculation bed in periodontal tissues by laser doppler flowmetry

2015 ◽  
Vol 9 (2) ◽  
pp. 0-0
Author(s):  
Коровкин ◽  
V. Korovkin ◽  
Ипполитов ◽  
Yuriy Ippolitov ◽  
Коровкина ◽  
...  
Keyword(s):  
Laser Doppler Flowmetry ◽  
Chaotic Behavior ◽  
Laser Doppler ◽  
Control Group ◽  
Oscillatory Process ◽  
Blood Flow Oscillations ◽  
Doppler Flowmetry ◽  
Periodontal Tissues ◽  
Linear Dynamic ◽  
Non Linear

The article discusses the assessment of the level of interconnection of non-linear dynamic and oscillatory processes in the microvasculature of periodontal tissues by laser Doppler flowmetry. For this purpose an examination of 62 patients aged 18-36 years was carried out. The control group consisted of 20 healthy indi-viduals without co-morbidities with intact periodontium. The 1st group was 20 patients with chronic catarrhal gingivitis mild; the 2nd group – 22 patients with chronic generalized periodontitis mild. The laser Doppler flow-metry with spectral continuous wavelet analysis of the blood flow oscillations was carried out by the apparatus LACC-02 (SPE &#34;LAZMA&#34;, Russia). In the course of the study the authors evaluated the relative vibration ener-gy of E0 flow using spectral analysis of the records of the LDF (program 2.2.509 - SPE &#34;LAZMA&#34;, Russia) and normalized nonlinear dynamic parameters of microcirculation of periodontal tissues. This allows to reveal their relationship to the parameters of the oscillatory process, to conduct its analysis, to understand the state of the macroscopic behaviour of the modulating factors, both in normal and in pathological conditions. As result of this study, it was found that the changes of the normalized nonlinear parameters microvasculature of periodontal tissues during the inflammatory process (I and II study group) were characterized by a decrease of the chaotic behavior of the system of microcirculation and its order on the basis of the numerical parameters of randomness (*, D2 N).

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