scholarly journals Diagnostic capabilities of different methods of laser doppler flowmetry spectral indexes assessment in patients with diabetic microangiopathy

2021 ◽  
Vol 10 (2) ◽  
pp. 18-24
Author(s):  
P. V. Vasilev ◽  
N. P. Erofeev ◽  
A. N. Shishkin
Keyword(s):  
Diabetes Mellitus ◽  
Laser Doppler Flowmetry ◽  
Main Group ◽  
Laser Doppler ◽  
Diabetic Microangiopathy ◽  
Control Group ◽  
Spectral Parameters ◽  
Doppler Flowmetry ◽  
Diagnostic Capabilities ◽  
And Control

The article contains the results of a study of two different methods for calculating the spectral parameters of laser Doppler flowmetry in patients with diabetic microangiopathy caused by type 2 diabetes mellitus (main group) and those with excluded diabetes mellitus (control group). Spectral indices were calculated using either average or maximum amplitudes of the frequency ranges. When comparing the contribution of respiratory and pulse fluxmotions using average amplitudes, there were significant (p < 0.05) differences between the main and control groups. On the contrary, when using the maximum amplitudes, no significant differences were noted (p > 0.05). Also, significant correlations were found between the contributions of respiratory and pulse fluxmotions and the estimated glomerular filtration rate in the main group, using both calculation methods. These studies indicate the feasibility of using a technique based on the analysis of average amplitudes to increase the specificity of laser Doppler flowmetry as a method for diagnosing diabetic microangiopathy.

Peculiarities of microcirculation in periodont tissues in children of key age groups sufficient type 1 diabetes. Part II

2019 ◽  
Vol 24 (2) ◽  
pp. 108-119 ◽  
Author(s):  
B. N. Davydov ◽  
D. A. Domenyuk ◽  
S. V. Dmitrienko
Keyword(s):  
Diabetes Mellitus ◽  
Blood Flow ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Diabetic Microangiopathy ◽  
Healthy Children ◽  
Doppler Flowmetry

Relevance. Morpho-functional changes in peripheral circulation established in type 1 diabetes mellitus correlate with changes in central hemodynamics, allowing the use of microcirculation indicators as diagnostic and prognostic criteria for assessing the degree of functional vascular disorders. Identifcation of microcirculation features of the blood by the method of laser Doppler flowmetry in children with different experience of type 1 diabetes in key age categories.Materials and methods. The study included 67 children with type 1 diabetes mellitus aged 12-15 years with an experience of the disease from six months to ten years. The comparison group consisted of 38 healthy children. The state of the microvasculature was assessed by laser Doppler flowmetry using a laser analyzer for capillary blood flow LAKK-OP.Results. In children with an experience of type 1 diabetes of less than two years, microcirculation disorders in periodontal tissues correspond to the hyperemic form, accompanied by increased perfusion, a decrease in the amplitude of low-frequency oscillations, increased heart rate, high blood flling, and blood flow bypass. For children with an endocrinopathy experience of more than three years, microcirculation disorders correspond to a stagnant form, combined with a decrease in perfusion due to stagnation of blood in the venular link, endothelial domination with suppression of neurogenic and cardiac fluctuations, low efciency and redistribution of blood flow in favor of the nutritive link.Conclusions. With the increase in experience, the degree of compensation of type 1 diabetes, the progression of diabetic microangiopathy, it is advisable to designate two stages of development of microcirculatory disorders. Early – compensatory with active adaptation, including neurogenic and endothelial regulation mechanisms. Late – decompensation with passive adaptation, supporting the effectiveness of microcirculation due to myogenic control of regulation, shunting and increasing the rate of blood outflow.

scholarly journals Efficacy of Laser Doppler Flowmetry, as a Diagnostic Tool in Assessing Pulp Vitality of Traumatised Teeth. A Split Mouth Clinical Study

2021 ◽  
Vol 11 (8) ◽  
pp. 801
Author(s):  
Ani Belcheva ◽  
Maria Shindova ◽  
Reem Hanna
Keyword(s):  
Laser Doppler Flowmetry ◽  
Test Group ◽  
Laser Doppler ◽  
Permanent Teeth ◽  
Control Group ◽  
Eligibility Criteria ◽  
Doppler Flowmetry ◽  
Registration Number ◽  
Pulp Vitality ◽  
And Control

Aim: This study aimed to evaluate the efficacy of laser Doppler flowmetry (LDF) in determining the changes in the pulpal blood flow (PBF) during post-traumatic period of the traumatised permanent teeth. Methods: 88 teeth of 44 patients (mean age 10.30 ± 2.38) were recruited according to the eligibility criteria and divided into two groups: test group (44 traumatised teeth) and control group (44 sound and healthy teeth). The measurement of PBF was performed, using a LDF monitor. Results: The analysis of the LDF outcomes in function of diagnosis indicated that the measurements of the traumatised teeth were significantly higher than those of non-traumatised teeth (p ˂ 0.05). Conclusions: LDF application provides dentists with fundamental benefits in terms of an early and precise investigation of PBF. In addition, LDF is a useful monitoring tool for revascularization of traumatised teeth and reliable objective diagnostic indicator of pulp vitality. Trial registration: ClinicalTrials.gov (Registration number: NCT04967456).

Peculiarities of microcirculation in peridont tissues in children of key age groups sufficient type 1 diabetes. Part I

2019 ◽  
Vol 24 (1) ◽  
pp. 4-10
Author(s):  
B. N. Davydov ◽  
D. A. Domenyk ◽  
S. V. Dmitrienko
Keyword(s):  
Diabetes Mellitus ◽  
Blood Flow ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Diabetic Microangiopathy ◽  
Healthy Children ◽  
Doppler Flowmetry

The relevance of the research topic. Morpho-functional changes in peripheral circulation established in type 1 diabetes mellitus correlate with changes in central hemodynamics, allowing the use of microcirculation indicators as diagnostic and prognostic criteria for assessing the degree of functional vascular disorders.Purpose – identifcation of microcirculation features of the blood by the method of laser Doppler flowmetry in children with different experience of type 1 diabetes in key age categories.Methods. The study included 67 children with type 1 diabetes mellitus aged 12-15 years with an experience of the disease from six months to ten years. The comparison group consisted of 38 healthy children. The state of the microvasculature was assessed by laser Doppler flowmetry using a laser analyzer for capillary blood flow LAKK-OP.Results. In children with an experience of type 1 diabetes of less than two years, microcirculation disorders in periodontal tissues correspond to the hyperemic form, accompanied by increased perfusion, a decrease in the amplitude of low-frequency oscillations, increased heart rate, high blood flling, and blood flow bypass. For children with an endocrinopathy experience of more than three years, microcirculation disorders correspond to a stagnant form, combined with a decrease in perfusion due to stagnation of blood in the venular link, endothelial domination with suppression of neurogenic and cardiac fluctuations, low effciency and redistribution of blood flow in favor of the nutritive link.Summary. With the increase in experience, the degree of compensation of type 1 diabetes, the progression of diabetic microangiopathy, it is advisable to designate two stages of development of microcirculatory disorders. Early - compensatory with active adaptation, including neurogenic and endothelial regulation mechanisms. Late - decompensation with passive adaptation, supporting the effectiveness of microcirculation due to myogenic control of regulation, shunting and increasing the rate of blood outflow.

The response of skin perfusion and of rheological and immunological variables to intravenous prostanoid administration in Raynaud’s phenomenon secondary to collagenosis

VASA ◽  
2005 ◽  
Vol 34 (4) ◽  
pp. 243-249 ◽  
Author(s):  
Drinda ◽  
Neumann ◽  
Pöhlmann ◽  
Vogelsang ◽  
Stein ◽  
...  
Keyword(s):  
Laser Doppler Flowmetry ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Plasma Viscosity ◽  
Laser Doppler ◽  
Erythrocyte Aggregation ◽  
Control Group ◽  
Long Term Effects ◽  
Doppler Flowmetry

Background: Prostanoids are used in the treatment of Raynaud’s phenomenon and acral perfusion disorders secondary to collagenosis. In subjective terms, intravenous administration of these agents produces success in more than 50% of patients. The therapeutic outcome of clinical administration of alprostadil or iloprost may vary from individual to individual. Patients and methods: The following variables were analysed in a cross-over study in 27 patients with collagenosis and Raynaud’s phenomenon: plasma viscosity and erythrocyte aggregation (rheological variables), partial pressure of oxygen and laser Doppler flowmetry in the finger region, and lymphocyte phenotyping and interleukin (IL) determinations (immunological variables). Results: Laser Doppler flowmetry revealed significant differences between patients with secondary Raynaud’s phenomenon and a control group of 25 healthy subjects. Laser Doppler readings did not change significantly as a result of the treatments. Therapy with iloprost produced a reduction in IL-1beta, L-selectin (CD 62 L) and IL-6. Conclusion: The change in immunological variables due to iloprost may explain the long-term effects of prostaglandins in the treatment of Raynaud’s phenomenon. From our results it is not possible to infer any preference for iloprost or alprostadil.

METHOD FOR ANALYSIS OF THE DOPPLER-BROADENED SPECTRA OF LASER RADIATION FOR THE ASSESSMENT OF BLOOD MICROCIRCULATION DISTURBANCES IN DIABETES MELLITUS TYPE 2

2020 ◽  
Vol 4 (1) ◽  
pp. 80-87
Author(s):  
I.O. KOZLOV
Keyword(s):  
Diabetes Mellitus ◽  
Laser Radiation ◽  
Laser Doppler Flowmetry ◽  
Diabetes Mellitus Type 2 ◽  
Feature Space ◽  
Diabetes Mellitus Type ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
New Feature

The article is devoted to the development of laser Doppler flowmetry and analysis of the recorded signal to study the distribution of perfusion over the frequencies of Doppler broadening of laser radiation. The processing algorithm and the necessary technical conditions for the correct registration of the signal are shown. As examples of the proposed method implementation, the data are obtained from a healthy volunteer and a patient with diabetes mellitus type 2 and analyzed. According to the proposed method, processing of recorded data provides a new feature space for data analysis of laser Doppler flowmetry signal.

scholarly journals Evaluation of the marginal gingival health using laser doppler flowmetry

2006 ◽  
Vol 17 (3) ◽  
pp. 219-222 ◽  
Author(s):  
Hakan Develioglu ◽  
Bülent Kesim ◽  
Aykut Tuncel
Keyword(s):  
Blood Flow ◽  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Plaque Index ◽  
Tissue Blood Flow ◽  
Doppler Flowmetry ◽  
Gingival Health ◽  
Significant Difference ◽  
Clinical Indices ◽  
And Control

The purposes of this study were to compare the gingival blood flow (GBF) in test sites (teeth retaining fixed partial dentures) and control sites (contralateral natural teeth) and investigate whether there is any relationship between clinical indices and GBF values. Twelve healthy subjects (6 females and 6 males) aged 20 to 54 years were enrolled this study. The GBF was measured from the middle point of the marginal gingiva in the test and control sites using laser Doppler flowmetry (LDF). Additionally, plaque index, gingival index and probing depth measurements were recorded. Statistically significant difference (p<0.05) was found between the test and control sites for marginal GBF. In contrast, no significant difference (p>0.05) was found between test and control sites with respect to the clinical indices, except for plaque index. The findings of this study suggest that there is a significant relation between resin-bonded fixed partial dentures with margins located subgingivally and marginal GBF. Clinical indices are helpful to collect information about the clinical health status of gingival tissues, but GBF is a good tool to measure gingival tissue blood flow and assess periodontal health. In conclusion, laser Doppler flowmetry can be used together with clinical indices to evaluate the marginal gingival health.

Estimation of non-linear dynamic processes and oscillating circuit of microcirculation bed in periodontal tissues by laser doppler flowmetry

2015 ◽  
Vol 9 (2) ◽  
pp. 0-0
Author(s):  
Коровкин ◽  
V. Korovkin ◽  
Ипполитов ◽  
Yuriy Ippolitov ◽  
Коровкина ◽  
...  
Keyword(s):  
Laser Doppler Flowmetry ◽  
Chaotic Behavior ◽  
Laser Doppler ◽  
Control Group ◽  
Oscillatory Process ◽  
Blood Flow Oscillations ◽  
Doppler Flowmetry ◽  
Periodontal Tissues ◽  
Linear Dynamic ◽  
Non Linear

The article discusses the assessment of the level of interconnection of non-linear dynamic and oscillatory processes in the microvasculature of periodontal tissues by laser Doppler flowmetry. For this purpose an examination of 62 patients aged 18-36 years was carried out. The control group consisted of 20 healthy indi-viduals without co-morbidities with intact periodontium. The 1st group was 20 patients with chronic catarrhal gingivitis mild; the 2nd group – 22 patients with chronic generalized periodontitis mild. The laser Doppler flow-metry with spectral continuous wavelet analysis of the blood flow oscillations was carried out by the apparatus LACC-02 (SPE &#34;LAZMA&#34;, Russia). In the course of the study the authors evaluated the relative vibration ener-gy of E0 flow using spectral analysis of the records of the LDF (program 2.2.509 - SPE &#34;LAZMA&#34;, Russia) and normalized nonlinear dynamic parameters of microcirculation of periodontal tissues. This allows to reveal their relationship to the parameters of the oscillatory process, to conduct its analysis, to understand the state of the macroscopic behaviour of the modulating factors, both in normal and in pathological conditions. As result of this study, it was found that the changes of the normalized nonlinear parameters microvasculature of periodontal tissues during the inflammatory process (I and II study group) were characterized by a decrease of the chaotic behavior of the system of microcirculation and its order on the basis of the numerical parameters of randomness (*, D2 N).

Approaches to improve the predictive value of laser Doppler flowmetry in detection of microcirculation disorders in diabetes mellitus

2018 ◽  
Vol 70 (2) ◽  
pp. 173-179 ◽  
Author(s):  
Dmitry Kulikov ◽  
Alexey Glazkov ◽  
Alexander Dreval ◽  
Yulia Kovaleva ◽  
Dmitry Rogatkin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Laser Doppler Flowmetry ◽  
Predictive Value ◽  
Laser Doppler ◽  
Doppler Flowmetry
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