Relation between lymphatic vessel diameter and clinicopathologic parameters in squamous cell carcinomas of the oral region

2000 ◽  
Vol 29 (3) ◽  
pp. 232-234
Author(s):  
A. Nakayama ◽  
A. Ogawa ◽  
Y. Fukuta ◽  
K. Kudo
Keyword(s):  
Squamous Cell ◽  
Lymphatic Vessel ◽  
Vessel Diameter ◽  
Squamous Cell Carcinomas ◽  
Oral Region ◽  
Clinicopathologic Parameters

scholarly journals Clinical aspects of lymphatic metastasis and prognosis of squamous cell carcinomas in the oral region.

1990 ◽  
Vol 36 (8) ◽  
pp. 1915-1921
Author(s):  
Ryosuke SHIBA ◽  
Sumio SAKODA ◽  
Ryoji ARIMA ◽  
Kiyotsugu KAWASAKI ◽  
Hidetsugu NISHIKII
Keyword(s):  
Squamous Cell ◽  
Lymphatic Metastasis ◽  
Squamous Cell Carcinomas ◽  
Clinical Aspects ◽  
Oral Region

Immunohistochemical comparative analysis of lymphatic vessel density and VEGF-C expression in squamous cell carcinomas of the tongue between young and old patients

2016 ◽  
Vol 212 (12) ◽  
pp. 1095-1101 ◽  
Author(s):  
Jamile Marinho Bezerra de Oliveira Moura ◽  
Adriana Costa de Souza Martins Câmara ◽  
Cassiano Francisco Weege Nonaka ◽  
Leão Pereira Pinto ◽  
Lélia Batista de Souza
Keyword(s):  
Comparative Analysis ◽  
Squamous Cell ◽  
Lymphatic Vessel ◽  
Squamous Cell Carcinomas ◽  
Vessel Density ◽  
Lymphatic Vessel Density ◽  
Old Patients

Clinicopathologic Parameters Related to Recurrence and Locoregional Metastasis in 180 Oral Squamous Cell Carcinomas

2013 ◽  
Vol 22 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Lucio Montebugnoli ◽  
Davide Bartolomeo Gissi ◽  
Federica Flamminio ◽  
Luciano Gentile ◽  
Vittorio Dallera ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas ◽  
Clinicopathologic Parameters

scholarly journals Frequent Alteration of Annexin A9 and A10 in HPV-Negative Head and Neck Squamous Cell Carcinomas: Correlation with the Histopathological Differentiation Grade

2019 ◽  
Vol 8 (2) ◽  
pp. 229 ◽  
Author(s):  
Cecilia Salom ◽  
Saúl Álvarez-Teijeiro ◽  
M. Pilar Fernández ◽  
Reginald O. Morgan ◽  
Eva Allonca ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Histological Differentiation ◽  
Normal Epithelium ◽  
Marked Contrast ◽  
Tissue Samples ◽  
Altered Expression ◽  
Disease Outcomes ◽  
Clinicopathologic Parameters

The annexin protein superfamily has been implicated in multiple physiological and pathological processes, including carcinogenesis. Altered expression of various annexins has frequently been observed and linked to the development and progression of various human malignancies. However, information is lacking on the expression and clinical significance of annexin A9 (ANXA9) and A10 (ANXA10) in head and neck squamous cell carcinomas (HNSCC). ANXA9 and ANXA10 expression was evaluated in a large cohort of 372 surgically treated HPV-negative HNSCC patients and correlated with the clinicopathologic parameters and disease outcomes. Down-regulation of ANXA9 expression was found in 42% of HNSCC tissue samples, compared to normal epithelia. ANXA9 expression in tumors was significantly associated with oropharyngeal location and histological differentiation grade (P < 0.001). In marked contrast, ANXA10 expression was absent in normal epithelium, but variably detected in the cytoplasm of cancer cells. Positive ANXA10 expression was found in 64% of tumors, and was significantly associated with differentiation grade (P < 0.001), being also more frequent in oropharyngeal tumors (P = 0.019). These results reveal that the expression of both ANXA9 and ANXA10 is frequently altered in HNSCC and associated to the tumor differentiation grade, suggesting that they could be implicated in the pathogenesis of these cancers.

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