Sexual desire includes complex motivation and drive. In the context of biological and cognitive-
emotive state art of science, it is often a neglected field in medicine. In regard to the treatment,
study on women’s sexual function received less attention compared to the men’s sexuality. In the past,
this endeavor was relatively not well disseminated in the scientific community. Recently, there was a
revolutionized surge of drug targets available to treat women with low sexual desire. It is timely to review
the relevant biological approach, especially in the context of pharmacotherapy to understand this
interesting clinical entity which was modulated by numerous interactive psychosocial inter-play and
factors. The complex inter-play between numerous dimensional factors lends insights to understand
the neural mechanism, i.e. the rewards centre pathway and its interaction with external psychosocialstimulus,
e.g. relationship or other meaningful life events. The function of hormones, e.g. oxytocin or
testosterone regulation was described. The role of neurotransmitters as reflected by the introduction of
a molecule of flibenserin, a full agonist of the 5-HT1A and partial agonist of the D4 to treat premenopausal
women with low sexual desire was deliberated. Based on this fundamental scientific core
knowledge, we suggest an outline on know-how of introduction for sex therapy (i.e. “inner-self” and
“outer-self”) where the role of partner is narrated. Then, we also highlighted on the use of pharmacological
agent as an adjunct scope of therapy, i.e. phosphodiasterase-5 (PDE-5) inhibitors and hormonal
treatment in helping the patient with low sexual desire.