The present paper is the product of collaboration between a neuroscientist, an ethicist, and a contemplative exploring issues around leadership, morality, and ethics. It is an exploration on how people in roles of responsibility can better understand how to engage in discernment processes with more awareness and a deeper sense of responsibility for others and themselves. It draws upon recent research and scholarship in neuroscience, contemplative science, and applied ethics to develop a practical understanding of how moral decision-making works and is essential in this time when there can seem to be an increasing moral vacuum in leadership.