Predicting the risk of becoming lost to follow-up in a lifestyle weight-loss intervention

Background: Obesity is a risk factor for frailty and muscle weakness, so weight loss in obese older adults may prevent frailty and functional decline. Objective: To assess the safety and efficacy of a multimodal weight-loss intervention in improving functional performance and reducing frailty risk in obese older adults. Design: Randomized controlled trial with 2 parallel arms. Setting and participants: Community-dwelling obese adults aged 65-75 years with body mass index (BMI) 30-39 kg/m2. Intervention: 6-month multimodal intervention based on diet and a physical activity program. Control group: Usual care. Main and secondary outcome measures: Frailty (Fried criteria) rate and functional performance at 6, 12, and 24 months of follow-up, respectively. Intermediate outcome measures: Weight loss, body composition changes, and metabolic and inflammatory biomarker changes. Results: N=305. The study intervention increased gait speed at 12 and 24 months of follow-up, but had no significant effect on frailty prevention. It was effective in reducing weight, BMI, fat mass, interleukin 6, and insulin resistance and improving self-reported quality of life. Conclusions: The study intervention was not demonstrated to be effective in preventing frailty in obese people aged 65-75 years at 24 months of follow-up. However, it allowed weight loss and a reduction in inflammatory and insulin resistance markers, which could have a long-term effect on frailty that requires further research.

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Changes in physical activity during a weight loss intervention and follow‐up: a randomized controlled trial

Clinical Obesity ◽

10.1111/cob.12057 ◽

2014 ◽

Vol 4 (3) ◽

pp. 127-135 ◽

Cited By ~ 11

Author(s):

N. R. Fuller ◽

K. Williams ◽

R. Shrestha ◽

A. L. Ahern ◽

C. Holzapfel ◽

...

Keyword(s):

Physical Activity ◽

Weight Loss ◽

Randomized Controlled Trial ◽

Controlled Trial ◽

Weight Loss Intervention ◽

Randomized Controlled

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Repeated lifestyle interventions lead to progressive weight loss: A retrospective review chart study

Scandinavian Journal of Public Health ◽

10.1177/1403494817693709 ◽

2017 ◽

Vol 45 (3) ◽

pp. 305-313 ◽

Cited By ~ 5

Author(s):

Sune Dandanell ◽

Christian Ritz ◽

Elisabeth Verdich ◽

Flemming Dela ◽

Jørn W. Helge

Keyword(s):

Weight Loss ◽

Body Weight ◽

Retrospective Review ◽

Fat Free Mass ◽

Lifestyle Interventions ◽

Weight Cycling ◽

Weight Loss Programme ◽

Progressive Weight Loss ◽

Lost To Follow Up

Aims: This study aimed to investigate whether repeated lifestyle interventions lead to progressive weight loss or to weight cycling. Methods: A retrospective review chart study with follow-up on 2120 participants (mean±SD age 36±15 years; body weight 116±28 kg; fat 43±6%). All had participated in one to four 11–12 week lifestyle interventions (residential weight loss programme, mixed activities). Weight loss was promoted through a hypocaloric diet (−500 to −700 kcal/day) and daily physical activity (1–3 hours/day). Primary outcomes were weight loss and change in body composition (bioimpedance measurements) after the intervention periods and at follow-up. Results: A total of 2120, 526, 139 and 47 people participated in one to four interventions with mean±SEM times from start to follow-up of 1.3±0.1, 2.9±0.2, 4.2±0.3 and 5.2±0.4 years respectively. Overall 50, 41, 18 and 11% of the participants were lost to follow-up after one to four interventions, respectively. The cumulated weight loss at follow-up increased with the number of interventions from one to four: 12.2±0.1, 15.9±0.7, 16.1±1.2 and 18.5±2.0 kg ( p<0.001). The ratios between cumulated loss of fat and fat free mass after one to four interventions decreased with the number of interventions (2.4, 2.2, 2.1 and 1.4). Rates of weight loss during the interventions ranged from 0.70±0.06 to 1.06±0.01 kg/week and the maximum weight regain during the follow-up periods was 0.039±0.007 kg/week. Conclusions: Repeated relatively short lifestyle interventions in a selected and motivated group can be an efficient method for weight loss maintenance with only limited body weight cycling in the interim periods. However, the relationship between loss of fat and fat free mass might change in an unfavourable direction.

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Adapting a Behavioral Weight Loss Intervention for Delivery via Facebook: A Pilot Series Among Low-Income Postpartum Women (Preprint)

10.2196/preprints.9597 ◽

2017 ◽

Author(s):

Valerie J. Silfee ◽

Andrea Lopez-Cepero ◽

Stephenie C. Lemon ◽

Barbara Estabrook ◽

Oanh Nguyen ◽

...

Keyword(s):

Weight Loss ◽

Low Income ◽

Retention Rate ◽

Future Research ◽

Postpartum Women ◽

Evidence Based ◽

Weight Loss Intervention ◽

Behavioral Weight Loss ◽

Weight Loss Interventions

BACKGROUND Efforts to translate evidence-based weight loss interventions, such as the Diabetes Prevention Program (DPP), to low-income postpartum women have resulted in poor intervention attendance and high attrition. Strategies that improve engagement and retention in this population are needed to maximize the reach of evidence-based weight loss interventions. OBJECTIVE The objective of this study was to adapt a DPP-based weight loss intervention (Fresh Start) for Facebook delivery and to evaluate its feasibility among low-income postpartum women. METHODS This study comprised 3 single-group pilot studies where feasibility outcomes iteratively informed changes from one pilot to the next. We paralleled the in-person program for Facebook delivery by translating the protocol to a content library of Facebook posts with additional posts from lifestyle coaches. Low-income postpartum women were recruited from Women, Infants, and Children (WIC) clinics in Worcester, Massachusetts. Participants were enrolled into a 16-week weight loss intervention delivered via Facebook. During the first 8 weeks, Facebook intervention posts were delivered 2 times per day, with additional posts from coaches aiming to stimulate interaction among participants or respond to participants’ questions and challenges. For the following 8 weeks, posts were delivered once per day without additional coaching. Feasibility outcomes were engagement (defined by number of likes, comments, and posts measured throughout intervention delivery), acceptability, and retention (survey at follow-up and assessment completion rate, respectively). Changes in weight were also assessed at baseline and follow-up. RESULTS Pilot 1 had a retention rate of 89% (24/27), and on average, 62% (17/27) of women actively engaged with the group each week during the 8-week coached phase. Mean weight loss was 2.6 (SD 8.64) pounds, and 79% (19/27) would recommend the program to a friend. Pilot 2 had a retention rate of 83% (20/24), and on average, 55% (13/24) of women actively engaged with the group weekly during the 8-week coached phase. Mean weight loss was 2.5 (SD 9.23) pounds, and 80% (16/24) would recommend the program to a friend. Pilot 3 had a retention rate of 88% (14/16), and on average, 67% (11/16) of women actively engaged with the group weekly during the 8-week coached phase. Mean weight loss was 7.0 (SD 11.6) pounds, and 100% (16/16) would recommend the program to a friend. CONCLUSIONS Our findings demonstrated that a Facebook-delivered intervention was acceptable and could be feasibly delivered to low-income postpartum women. Future research is needed to evaluate the efficacy of a Facebook-delivered weight loss intervention.

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Predictors of Weight Regain in a Long-Term Follow-Up of a Weight Loss Intervention

Medicine & Science in Sports & Exercise ◽

10.1249/01.mss.0000273588.17193.ff ◽

2007 ◽

Vol 39 (Supplement) ◽

pp. S160

Author(s):

Timothy Lohman ◽

Scott Going ◽

Ellen Cussler ◽

Lauve Metcalfe ◽

Pedro Teixeira

Keyword(s):

Weight Loss ◽

Weight Regain ◽

Weight Loss Intervention ◽

Long Term Follow Up

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TP6.2.20 UK- single centre experience with the ElipseTM intragastric balloon; Early safety and effectiveness

British Journal of Surgery ◽

10.1093/bjs/znab362.047 ◽

2021 ◽

Vol 108 (Supplement_7) ◽

Author(s):

Bankole Oyewole ◽

Irena Stefanova ◽

Anu Sandhya ◽

Shannon Mangat ◽

Simon Monkhouse

Keyword(s):

Weight Loss ◽

Final Analysis ◽

Total Body Weight ◽

Acid Reflux ◽

Abdominal Radiograph ◽

Balloon Expulsion ◽

Total Body ◽

The Uk ◽

Lost To Follow Up

Abstract Introduction The ElipseTM gastric balloon (EIGB) is an established outpatient, non-invasive, non-surgical device for weight-loss not requiring endoscopy nor sedation. This study reports the early safety and effectiveness from the largest and only reported UK cohort treated with the EIGB. Methods A retrospective study of 224 consecutive patients undergoing EIGB insertion between May 2018 and December 2020 was performed. EIGB placement involved swallowing of the ElipseTM capsule followed by a pre-inflation abdominal radiograph to confirm position. Inflation was performed with 550mls of sterile water followed by a post-inflation radiograph. Patients had weekly follow-up to assess symptoms, weight-loss, time and route of balloon expulsion. Results 224 patients underwent EIGB insertion during the study period; 39 patients were lost to follow-up. 185 patients (28 male and 157 female) were included in the final analysis with a mean age of 38.1 years. Mean study follow-up was 10 weeks, mean weight at insertion was 97.7 kg. Mean %Total Body Weight (TBW) loss was 6.5% at 4 weeks and 9% at last follow-up. 32 patients had 15.3 %TBW loss at 16 weeks follow-up. Frequently experienced symptoms during the first week were acid reflux, abdominal pain and bloating, nausea and vomiting. One patient had early expulsion at 8 weeks. Seven patients required early deflation due to severe symptoms (5), pancreatitis (1) and hyperinflation (1). Conclusion EIGB is a safe and effective method of weight loss. Longer follow-up studies in the UK population are required to assess overall patient outcomes and associated factors for weight loss.

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Influence of co-morbidity on body composition changes after weight loss intervention among overweight housewives: a follow-up study of the MyBFF@home

BMC Women s Health ◽

10.1186/s12905-018-0600-6 ◽

2018 ◽

Vol 18 (S1) ◽

Author(s):

Nur Shahida Abdul Aziz ◽

Suzana Shahar ◽

Rashidah Ambak ◽

Noor Safiza Mohamad Nor ◽

Ahmad Taufik Jamil ◽

...

Keyword(s):

Weight Loss ◽

Body Composition ◽

Weight Loss Intervention ◽

Follow Up Study ◽

Co Morbidity ◽

Composition Changes

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Revisional One Anastomosis Gastric Bypass with a 150-cm Biliopancreatic Limb After Failure of Adjustable Gastric Banding: Mid-Term Outcomes and Comparison Between One- and Two-Stage Approaches

Obesity Surgery ◽

10.1007/s11695-021-05728-9 ◽

2021 ◽

Author(s):

Niccolò Petrucciani ◽

Francesco Martini ◽

Marine Benois ◽

Radwan Kassir ◽

Hubert Boudrie ◽

...

Keyword(s):

Weight Loss ◽

Gastric Bypass ◽

Gastric Banding ◽

Adjustable Gastric Banding ◽

Postoperative Morbidity ◽

Biliopancreatic Limb ◽

The Mean ◽

Lost To Follow Up

Abstract Purpose Laparoscopic adjustable gastric banding (LAGB) was a common procedure worldwide but associated with a high rate of long-term failure. This study aims to evaluate the safety and effectiveness of conversion to one anastomosis gastric bypass (OAGB) after failed LAGB. Materials and Methods We undertook a retrospective analysis of a prospectively maintained database in a tertiary referral center for bariatric surgery. All cases of revisional OAGB with a biliopancreatic limb (BPL) of 150 cm after failed LAGB performed between 2010 and 2016 were analyzed. Results Overall, 215 patients underwent conversion from LAGB to OAGB. Indication for surgery was primary weight loss (WL) failure in 30.7% of cases and long-term complications in the remaining patients, with or without associated weight regain. At the time of OAGB, the mean age was 43.2 ± 10.5 years and the mean BMI was 42 ± 6.9. Overall postoperative morbidity was 13.5%. The postoperative abscess ± leak rate was 5.9% in the overall population. Two years after OAGB, 9.7% of patients were lost to follow-up, % excess weight loss (EWL) was 88.2 ± 23.9, and % total weight loss (TWL) was 38.7 ± 9.3. At 5 years, 16.6% of patients were lost to follow-up, %EWL was 82.4 ± 25, and %TWL was 36.1 ± 10. There was no statistical difference in complication rates or WL results between the one-stage and two-stage approaches. Conclusion OAGB with a 150-cm BPL represents a safe and effective option after failed LAGB. Both synchronous OAGB and two-step revisional OAGB guarantee satisfying results in terms of postoperative morbidity and WL outcomes. Graphical abstract (PLEASE CORRECT THE GRAPHICAL ABSTRACT !!! 215 PATIENTS INSTEAD OF 250

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Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in Inducing Weight Loss among Obese Filipino Patients: A Randomized Controlled Trial

Journal of the ASEAN Federation of Endocrine Societies ◽

10.15605/jafes.035.02.06 ◽

2020 ◽

Vol 35 (2) ◽

pp. 181-189

Author(s):

Margaret Encarnacion ◽

◽

Oliver Allan Dampil ◽

Ludwig Damian ◽

Maria Leila Doquenia ◽

...

Keyword(s):

Weight Loss ◽

Repetitive Transcranial Magnetic Stimulation ◽

Controlled Trial ◽

Caloric Intake ◽

P Value ◽

Sham Stimulation ◽

Parallel Group ◽

Significant Difference ◽

Lost To Follow Up

Objective. To determine the efficacy of rTMS in decreasing body mass index (BMI) versus sham stimulation among obese Filipino patients. Methodology. This was a single-center, randomized, sham-controlled, single-blind, parallel group trial. Participants were 15-65 years old with BMI ≥30 kg/m2 and weight stable for 6 weeks. Participants were randomized to receive real rTMS or sham stimulation. Each underwent 4 sessions of stimulation over 2 weeks. Anthropometrics, total caloric intake (TCI), and VAS score for appetite were taken at baseline, 2, 4, 6, and 12 weeks. Results. A total of 31 patients were randomized with 15 to the treatment and 14 to sham stimulation completing treatment, with 2 lost to follow-up. A significant decrease in BMI was noted after 4 weeks from the start of rTMS in the treatment group, (0.6±0.6, p-value=0.001), with weight change of -1.3±1.3 kg (p-value=0.009), but was no longer observed at 6 weeks onwards. No severe adverse effects were noted. Conclusion. rTMS to the DLPFC effectively decreased BMI (0.6±0.6) and weight (-1.3±1.3 kg) from baseline to 4 weeks. At 6-12 weeks after rTMS however, there was no longer a significant difference, indicating that 4 sessions of rTMS may not be enough to produce a prolonged effect on weight loss.

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