Objective: College students have an increased risk for cannabis use and trauma exposure. Cannabis use and trauma exposure have a reciprocal relationship and given the potential negative consequences of both (e.g., poor academic outcomes), there is a need to understand their co-occurring etiology. Two primary etiologic models exist: self-medication (i.e., trauma cannabis use) and high-risk (i.e., cannabis use trauma exposure) hypotheses. The purpose of this study is to investigate the bidirectional relationship between cannabis use and interpersonal trauma (IPT) exposure above and beyond established covariates (e.g., sex, race, alcohol, nicotine).Method: Participants are from an ongoing longitudinal study on college behavioral health at a mid-Atlantic public university (Dick et al., 2014). The present study used data from the first assessment (i.e., baseline survey at year 1 Fall) and one follow-up assessment (i.e., year 1 Spring). Participants were 4 cohorts of college students (n = 9,889) who completed measures of demographic variables, substance use (e.g., cannabis, alcohol, nicotine), and IPT. Associations between cannabis use and IPT and covariates (e.g., sex, race, cohort, alcohol, nicotine) were estimated using cross-lagged path analyses.Results: Results supported the self-medication hypothesis (i.e., IPT cannabis use), but not the high-risk hypothesis (i.e., cannabis use IPT). Alcohol and nicotine use were also significant predictors of both cannabis use and IPT.Conclusions: These findings provide preliminary support for the self-medication hypothesis, indicating that those reporting IPT exposure may be at risk for cannabis use. Implications of these findings, in light of study limitations, are discussed.