Effects of microiontophoretically applied methionine-enkephalin on single neurones in rat brainstem

Nature ◽  
1976 ◽  
Vol 261 (5559) ◽  
pp. 425-426 ◽  
Author(s):  
P. B. BRADLEY ◽  
I. BRIGGS ◽  
R. J. GAYTON ◽  
LYNN A. LAMBERT
Keyword(s):  
Methionine Enkephalin ◽  
Single Neurones ◽  
Rat Brainstem

Rat brainstem neurons responsive to changes in portal blood sodium concentration

1984 ◽  
Vol 247 (5) ◽  
pp. R792-R799 ◽  
Author(s):  
P. J. Kahrilas ◽  
R. C. Rogers
Keyword(s):  
Hypertonic Saline ◽  
Choline Chloride ◽  
Vena Cava ◽  
Sodium Concentration ◽  
Portal Blood ◽  
Solitary Tract ◽  
Sprague Dawley ◽  
Response Characteristics ◽  
Medial Nucleus ◽  
Rat Brainstem

Studies were performed to identify the response characteristics of nucleus of the solitary tract neurons receiving afferent projections from the hepatic branch of the vagus nerve. Thirty Sprague-Dawley rats under pentobarbital anesthesia had catheters placed in the ileocolic vein and the inferior vena cava. Neuronal recordings were made in the left medial nucleus of the solitary tract (NST), in the area where hepatic vagal fibers terminate. Sixteen NST cells were identified that responded selectively to the portal infusion of water or hypertonic saline. Two patterns of response were seen: 1) 12 neurons were persistently stimulated by portal hypertonic saline and persistently inhibited by portal water, and 2) four neurons were either transiently excited (n = 3) or transiently inhibited (n = 1) by portal hypertonic saline with no water effect. All units recorded responded to changes of 1% or less in portal blood sodium concentration. Hypertonic mannitol was an ineffective stimulus but choline chloride was as effective as sodium chloride. This suggests that the hepatic receptors utilize an Na+-K+-ATPase electrogenic pump in the transduction process.

scholarly journals RADIOIMMUNOASSAY OF METHIONINE ENKEPHALIN AND INTERFERENCE BY BRAIN FACTOR OF IM MUNOREACTI VIT Y AND OPIATE RECEPTOR BINDING ACTIVITY

1979 ◽  
Vol 29 (2) ◽  
pp. 203-209 ◽  
Author(s):  
Masakatsu TAKAHASHI ◽  
Hiroshi KANETO ◽  
Eiko UENO ◽  
Joe WATANABE ◽  
Masao KOIDA ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Opiate Receptor ◽  
Binding Activity ◽  
Methionine Enkephalin ◽  
Receptor Binding Activity ◽  
Brain Factor
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