scholarly journals Anticancer bioactive peptides suppress human colorectal tumor cell growth and induce apoptosis via modulating the PARP-p53-Mcl-1 signaling pathway

2015 ◽  
Vol 36 (12) ◽  
pp. 1514-1519 ◽  
Author(s):  
Li-ya Su ◽  
Ying-xu Shi ◽  
Mei-rong Yan ◽  
Yaguang Xi ◽  
Xiu-lan Su
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Signaling Pathway ◽  
Bioactive Peptides ◽  
Colorectal Tumor ◽  
Tumor Cell Growth ◽  
Colorectal Tumor Cell

scholarly journals HIF-3α1 promotes colorectal tumor cell growth by activation of JAK-STAT3 signaling

Oncotarget ◽  
2016 ◽  
Vol 7 (10) ◽  
pp. 11567-11579 ◽  
Author(s):  
Xiang Xue ◽  
Kylie Jungles ◽  
Gunseli Onder ◽  
Jalal Samhoun ◽  
Balázs Győrffy ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Colorectal Tumor ◽  
Tumor Cell Growth ◽  
Stat3 Signaling ◽  
Colorectal Tumor Cell

Abstract 2294: Sophorolipid-mediated inhibition of colorectal tumor cell growth in vitro and in vivo

2015 ◽  
Author(s):  
Breedge Callaghan ◽  
Sophie Roelants ◽  
Niki Baccile ◽  
Helen Lydon ◽  
Inge Van Bogaert ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Colorectal Tumor ◽  
Tumor Cell Growth ◽  
Colorectal Tumor Cell

scholarly journals Afatinib and its encapsulated polymeric micelles inhibits HER2-overexpressed colorectal tumor cell growth in vitro and in vivo

Oncotarget ◽  
2014 ◽  
Vol 5 (13) ◽  
pp. 4868-4880 ◽  
Author(s):  
Siao-Syun Guan ◽  
Jungshan Chang ◽  
Chun-Chia Cheng ◽  
Tsai-Yueh Luo ◽  
Ai-Sheng Ho ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Polymeric Micelles ◽  
Colorectal Tumor ◽  
Tumor Cell Growth ◽  
Colorectal Tumor Cell

Novel Gemini-vitamin D3 analog inhibits tumor cell growth and modulates the Akt/mTOR signaling pathway

2006 ◽  
Vol 100 (4-5) ◽  
pp. 107-116 ◽  
Author(s):  
James O’Kelly ◽  
Milan Uskokovic ◽  
Nathan Lemp ◽  
Jay Vadgama ◽  
H. Phillip Koeffler
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Signaling Pathway ◽  
Vitamin D3 ◽  
Mtor Signaling ◽  
Tumor Cell Growth ◽  
Mtor Signaling Pathway

scholarly journals Esterase D stabilizes FKBP25 to suppress mTORC1

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Yuejun Yang ◽  
Xinpeng Chen ◽  
Wen Yao ◽  
Xiaoling Cui ◽  
Na Li ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Signaling Pathway ◽  
Nonspecific Esterase ◽  
Tumor Cell Growth ◽  
Yeast Two Hybrid ◽  
Mtorc1 Signaling ◽  
Two Hybrid

Abstract Background Esterase D (ESD) is a nonspecific esterase that detoxifies formaldehyde. Many reports have stated that ESD activity is associated with a variety of physiological and pathological processes. However, the detailed signaling pathway of ESD remains poorly understood. Methods Considering the advantages of the small chemical molecule, our recent work demonstrated that 4-chloro-2-(5-phenyl-1-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl) phenol (FPD5) activates ESD, and will be a good tool for studying ESD further. Firstly, we determined the interaction between ESD and FK506 binding protein 25 (FKBP25) by yeast two-hybrid assay and co-immunoprecipitation (CO-IP) and analyzed the phosphorylation levels of mTORC1, P70S6K and 4EBP1 by western blot. Furthermore, we used the sulforhodamine B (SRB) and chick chorioallantoic membrane (CAM) assay to analyze cell viability in vitro and in vivo after treatment with ESD activator FPD5. Results We screened FKBP25 as a candidate protein to interact with ESD by yeast two-hybrid assay. Then we verified the interaction between ESD and endogenous FKBP25 or ectopically expressed GFP-FKBP25 by CO-IP. Moreover, the N-terminus (1–90 aa) domain of FKBP25 served as the crucial element for their interaction. More importantly, ESD reduced the K48-linked poly-ubiquitin chains of FKBP25 and thus stabilized cytoplasmic FKBP25. ESD also promoted FKBP25 to bind more mTORC1, suppressing the activity of mTORC1. In addition, ESD suppressed tumor cell growth in vitro and in vivo through autophagy. Conclusions These findings provide novel evidence for elucidating the molecular mechanism of ESD and ubiquitination of FKBP25 to regulate autophagy and cancer cell growth. The ESD/FKBP25/mTORC1 signaling pathway is involved in inhibiting tumor cell growth via regulating autophagy.

Abstract 779: Blockade of the IL-6/JAK/STAT3 signaling pathway inhibits pancreatic tumor cell growth in 3D spheroid cultures and in xenograft models

2015 ◽  
Author(s):  
Jun Li ◽  
Eian Caulder ◽  
Margaret Favata ◽  
Melody Diamond ◽  
Beth Rumberger ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Signaling Pathway ◽  
Pancreatic Tumor ◽  
Tumor Cell Growth ◽  
Stat3 Signaling ◽  
Pancreatic Tumor Cell ◽  
Stat3 Signaling Pathway ◽  
Xenograft Models

scholarly journals Targeting the EP1-FasL Signaling Pathway Reduces Colon Tumor Cell Growth In Vivo

2011 ◽  
Vol 140 (5) ◽  
pp. S-7
Author(s):  
Grace P. O'Callaghan ◽  
Peter Neary ◽  
Caitlin O'Mahony ◽  
Fergus Shanahan ◽  
Aileen Houston
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Signaling Pathway ◽  
Colon Tumor ◽  
Tumor Cell Growth ◽  
Colon Tumor Cell

scholarly journals Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-β–like signaling pathway

2009 ◽  
Author(s):  
Lihua Ding ◽  
Zhaoyun Wang ◽  
Jinghua Yan ◽  
Xiao Yang ◽  
Aijun Liu ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Signaling Pathway ◽  
Family Members ◽  
Tumor Cell Growth
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