scholarly journals Histological grading and clinical stage at presentation in breast carcinoma

1982 ◽  
Vol 46 (3) ◽  
pp. 457-458 ◽  
Author(s):  
S Thoresen
Keyword(s):  
Breast Carcinoma ◽  
Clinical Stage ◽  
Histological Grading

scholarly journals Breast Carcinoma, Intratumour Heterogeneity and Histological Grading, Using Geostatistics

2000 ◽  
Vol 20 (2-3) ◽  
pp. 83-91 ◽  
Author(s):  
Vénus Sharifi‐Salamatian ◽  
Anne de Roquancourt ◽  
Jean Paul Rigaut
Keyword(s):  
Breast Carcinoma ◽  
Tumour Progression ◽  
Methodological Approach ◽  
Histological Grading ◽  
Paraffin Sections ◽  
Satisfactory Solution ◽  
Ki 67 ◽  
Grade 3 ◽  
Survival Studies ◽  
Mib 1

Tumour progression is currently believed to result from genetic instability. Chromosomal patterns specific of a type of cancer are frequent even though phenotypic spatial heterogeneity is omnipresent. The latter is the usual cause of histological grading imprecision, a well documented problem, without any fully satisfactory solution up to now. The present article addresses this problem in breast carcinoma. The assessment of a genetic marker for human tumours requires quantifiable measures of intratumoral heterogeneity. If any invariance paradigm representing a stochastic or geostatistic function could be discovered, this might help in solving the grading problem. A novel methodological approach using geostatistics to measure heterogeneity is used. Twenty tumours from the three usual (Scarff‐Bloom and Richardson) grades were obtained and paraffin sections stained by MIB‐1 (Ki‐67) and peroxidase staining. Whole two‐dimensional sections were sampled. Morphometric grids of variable sizes allowed a simple and fast recording of positions of epithelial nuclei, marked or not by MIB‐1. The geostatistical method is based here upon the asymptotic behaviour of dispersion variance. Measure of asymptotic exponent of dispersion variance shows an increase from grade 1 to grade 3. Preliminary results are encouraging: grades 1 and 3 on one hand and 2 and 3 on the other hand are totally separated. The final proof of an improved grading using this measure will of course require a confrontation with the results of survival studies.

scholarly journals Factors affecting the concordance of radiologic and pathologic tumor size in breast carcinoma

Ultrasound ◽  
2018 ◽  
Vol 27 (1) ◽  
pp. 45-54 ◽  
Author(s):  
Ameer Hamza ◽  
Sidrah Khawar ◽  
Ramen Sakhi ◽  
Ahmed Alrajjal ◽  
Shelby Miller ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Tumor Size ◽  
Ductal Carcinoma ◽  
Clinical Stage ◽  
Clinical Staging ◽  
Size Difference ◽  
Surgical Decision ◽  
Factors Affecting ◽  
Stage Classification ◽  
The Mean

Background Radiologic assessment of tumor size is an integral part of the work-up for breast carcinoma. With improved radiologic equipment, surgical decision relies profoundly upon radiologic/clinical stage. We wanted to see the concordance between radiologic and pathologic tumor size to infer how accurate radiologic/clinical staging is. Materials and methods The surgical pathology and ultrasonography reports of patients with breast carcinoma were reviewed. Data were collected for 406 cases. Concordance was defined as a size difference within ±2 mm. Results The difference between radiologic and pathologic tumor size was within ±2 mm in 40.4% cases. The mean radiologic size was 1.73 ± 1.06 cm. The mean pathologic size was 1.84 ± 1.24 cm. A paired t-test showed a significant mean difference between radiologic and pathologic measurements (0.12 ± 1.03 cm, p = 0.03). Despite the size difference, stage classification was the same in 59.9% of cases. Radiologic size overestimated stage in 14.5% of cases and underestimated stage in 25.6% of cases. The concordance rate was significantly higher for tumors ≤2 cm (pT1) (51.1%) as compared to those greater than 2 cm (≥pT2) (19.7%) ( p < 0.0001). Significantly more lumpectomy specimens (47.5%) had concordance when compared to mastectomy specimens (29.8%) ( p < 0.0001). Invasive ductal carcinoma had better concordance compared to other tumors ( p = 0.02). Conclusion Mean pathologic tumor size was significantly different from mean radiologic tumor size. Concordance was in just over 40% of cases and the stage classification was the same in about 60% of cases only. Therefore, surgical decision of lumpectomy versus mastectomy based on radiologic tumor size may not always be accurate.

scholarly journals Robinson′s cytological grading on aspirates of breast carcinoma: Correlation with Bloom Richardson′s histological grading

2009 ◽  
Vol 26 (4) ◽  
pp. 140 ◽  
Author(s):  
SK Sinha ◽  
Namita Sinha ◽  
Ranjana Bandyopadhyay ◽  
SantoshK Mondal
Keyword(s):  
Breast Carcinoma ◽  
Histological Grading

scholarly journals Tumor-Infiltrating Lymphocytes in Breast Carcinoma: Immunohistochemical Analysis

2018 ◽  
Vol 3 (12) ◽  
Author(s):  
Dr. Amol R. R. Rajhans, MD ◽  
Dr. Deepak S. Howale
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
T Lymphocytes ◽  
Clinical Stage ◽  
Stage Iv ◽  
Stage I ◽  
Stage Ii ◽  
Stage Iii ◽  
Cd4 Cells ◽  
Infiltrating Lymphocytes

Breast cancer is the most common invasive cancer in women, and the second main cause of cancer death in women, after lung cancer. Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the nipple, a newly inverted nipple, or a red or scaly patch of skin. In those with distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin. In 2017, around 252, 710 new diagnoses of breast cancer are expected in women, and around 40,610 women are likely to die from the disease. Awareness of the symptoms and the need for screening are important ways of reducing the risk. Material and Methods: This retrospective study was carried out in the department of Pathology, DCP Consultant Pathologist Shashwat Hospitals, Pune, a total of 38 retrospective breast carcinoma tissues were obtained from female patients. Representative paraffin blocks and haematoxylin and eosin (HandE)-stained sections were retrieved from the pathology department. The patients' records were reviewed to look for the patient age and the clinical stage of the disease. The stage of the cancer was reported according to the American Joint Committee of Cancer. As tissue and patient data was collected in an anonymous way no written or informed consent was required for the study purpose. Results and Observations: According to data by clinical staging Stage I, Stage II, Stage III and Stage IV were 16 (42.11%), 11(28.95%), 7 (18.42%) and 4 (10.53%) respectively. According to histology Stage I, Stage II, Stage III and Stage IV were 2 (5.26%), 11(28.95%), 24 (63.16%) and 1 (2.63%) respectively. Hand E-stained sections showed that tumour-infiltrating lymphocytes (TILs) were present in 31 of the 38 carcinomas (81.58%). Majority of theTILs were T lymphocytes and was present in all 31 cases. CD4+ cells were seen31 patients and CD 8+ were seen in 25 cases. B cells were seen in 21 cases. TILs were analysed according to the clinical stage of breast cancer, stages III and IV tumors showed significantly higher densities of total lymphocytes, T lymphocytes, and CD4+ lymphocytes as compared to stage II tumors. Lymphocyte immuno phenotypes and the total TILs also showed a high significantly positive correlation between each lymphocyte population/subpopulation and the total TILs. Conclusion: T and B lymphocytes were expressed in breast carcinoma with High prevalence of T lymphocytes CD4+ cells. However larger no of cases are required to confirm the findings and extensive large studies are required.

scholarly journals Correlation of Robinson’s Cytological Grading of Breast Carcinoma with Bloom Richardson’s Histological Grading – A Teaching Institutional Experience in Mandya, Karnataka

2021 ◽  
Vol 8 (21) ◽  
pp. 1620-1623
Author(s):  
Kusuma Kodihalli Nagaraju ◽  
Chandana Nagendra ◽  
Shilpa Madhav Shetty
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Histological Grading ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Grade Ii ◽  
Needle Aspiration Cytology ◽  
Grade Iii

BACKGROUND Breast cancer is increasing in developing countries and the management options are wide; therefore, providing the surgeon with accurate prognostic information on which mode of therapy will be chosen becomes important. Fine needle aspiration cytology (FNAC) is a routinely used initial investigation of choice for rapid diagnosis of breast cancer. Apart from diagnosis of cancer, it also has the ability to predict the grade on smears which will add its diagnostic value without any additional morbidity or expense for the patients. Among various cytological grading systems, Robinson grading is most commonly used for breast carcinoma in fine needle aspirates. The purpose of this study is to evaluate the correlation between Robinson’s cytological grading and Bloom Richardson’s histological grading. METHODS This is a 3 - year retrospective analytical study. 40 cases of infiltrating duct carcinoma (IDC) of breast diagnosed on cytology were included in the study. Cytological grading was done using Robinson’s grading and corresponding histopathology slides were taken, and histological grading using Bloom Richardson’s system was done. Finally, correlation between cytological and histological grading was done using statistical package for social sciences (SPSS) software. RESULTS Age of the patients varied between 32 and 70 yrs. Cytologically, 32.5 % cases were grade I, 40 % were grade II and 27.5 % cases were grade III respectively. Histologically 22.5 %, 47.5 % and 30 % cases were grade I, grade II, and grade III, respectively. Concordance rate between grade I tumours in cytology and histology was 53.84 %, for grade II tumours it was 75 %, and for grade III tumours it was 63.63 %. The absolute concordance rate was 65 %. CONCLUSIONS Robinson’s cytological grading (RCG) of breast carcinoma correlates well with Bloom - Richardson’s histological grading system and could be a helpful parameter in selecting a neoadjuvant treatment for the breast cancer patients on fine needle aspiration cytology alone. KEYWORDS Breast Carcinoma, Robinson’s Cytological Grading, Bloom Richardson’s Histological Grading

scholarly journals ROBINSON’S CYTOLOGICAL GRADING ON ASPIRATES OF BREAST CARCINOMA AND CORRELATION WITH BLOOM-RICHARDSON’S HISTOLOGICAL GRADING

2017 ◽  
Vol 4 (2) ◽  
pp. 86-91
Author(s):  
Swayam Prava Pradhan ◽  
Anusuya Dash ◽  
Sulata Choudhury ◽  
Debi Prasad Mishra
Keyword(s):  
Breast Carcinoma ◽  
Histological Grading

Histological grading of invasive breast carcinoma – a simplification of existing methods in a large conservation series with long-term follow-up

2009 ◽  
Vol 55 (6) ◽  
pp. 724-731 ◽  
Author(s):  
Jeremy St J Thomas ◽  
Gillian R Kerr ◽  
Wilma J L Jack ◽  
Fiona Campbell ◽  
Laura McKay ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Invasive Breast Carcinoma ◽  
Histological Grading ◽  
Long Term Follow Up
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