African Buffalo persistently exposed to contagious foot and mouth diseases

Nature Africa ◽  
2021 ◽  
Author(s):  
Scovian Lillian
Keyword(s):  
African Buffalo ◽  
Mouth Diseases ◽  
Foot And Mouth

Natural transmission of foot-and-mouth disease virus from African buffalo (Syncerus caffer) to cattle in a wildlife area of Zimbabwe

1994 ◽  
Vol 134 (10) ◽  
pp. 230-232 ◽  
Author(s):  
P. Dawe ◽  
F. Flanagan ◽  
R. Madekurozwa ◽  
K. Sorensen ◽  
E. Anderson ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
African Buffalo ◽  
Syncerus Caffer ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals The role of African buffalo in the epidemiology of foot‐and‐mouth disease in sympatric cattle and buffalo populations in Kenya

2020 ◽  
Author(s):  
George P. Omondi ◽  
Francis Gakuya ◽  
Jonathan Arzt ◽  
Abraham Sangula ◽  
Ethan Hartwig ◽  
...  
Keyword(s):  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
African Buffalo ◽  
Foot And Mouth

scholarly journals Chemical Components of Ardisia splendens Leaves and Their Activity against Coxsackie A16 Viruses

2014 ◽  
Vol 9 (5) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Nguyen Thi Hong Van ◽  
Trinh Anh Vien ◽  
Nguyen Xuan Nhiem ◽  
Phan Van Kiem ◽  
Chau Van Minh ◽  
...  
Keyword(s):  
Flavonol Glycoside ◽  
Chemical Components ◽  
In Vitro Test ◽  
Srb Assay ◽  
Mouth Diseases ◽  
Chromatographic Methods ◽  
Foot And Mouth ◽  
Vitro Test

Using a combination of chromatographic methods, one new flavonol glycoside, myricetin 3,7-di-O-α-L-rhamnopyranoside (1), and nine known compounds myricitrin (2), quercetin 3,7-di-O-α-L-rhamnopyranoside (3), quercitrin (4), desmanthin-1 (5), myricetin 3-O -(3″-O-galloyl)-α-L-rhamnopyranoside (6), (+)-catechin (7), benzyl O-β-D-glucopyranoside (8), 2-phenylethyl O-β-D-glucopyranoside (9), and corilagin (10) were isolated from the leaves of Ardisia splendens Pit. Based on an in vitro test against Coxsackie viruses A16 by SRB assay, only compounds 2, 5, and 10 exhibited activity against Coxsackie viruses A16 with IC50 values of 40.1, 32.2, and 30.5 μM, respectively. This result suggested that compounds 2, 5, and 10 might be potential agents for treating hand, foot and mouth diseases.

scholarly journals Hand, foot, and mouth diseases.

1965 ◽  
Vol 40 (213) ◽  
pp. 560-564 ◽  
Author(s):  
S. R. Meadow
Keyword(s):  
Mouth Diseases ◽  
Foot And Mouth

Prospect and challenges for the development of multivalent vaccines against hand, foot and mouth diseases

Vaccine ◽  
2014 ◽  
Vol 32 (47) ◽  
pp. 6177-6182 ◽  
Author(s):  
Chia-Chyi Liu ◽  
Yen-Hung Chow ◽  
Pele Chong ◽  
Michel Klein
Keyword(s):  
Mouth Diseases ◽  
Foot And Mouth

scholarly journals Differential Persistence of Foot-and-Mouth Disease Virus in African Buffalo Is Related to Virus Virulence

2016 ◽  
Vol 90 (10) ◽  
pp. 5132-5140 ◽  
Author(s):  
Francois Maree ◽  
Lin-Mari de Klerk-Lorist ◽  
Simon Gubbins ◽  
Fuquan Zhang ◽  
Julian Seago ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Germinal Centers ◽  
Cell Killing ◽  
Mouth Disease ◽  
Lymphoid Tissues ◽  
African Buffalo ◽  
Mouth Disease Virus ◽  
Foot And Mouth

ABSTRACTFoot-and-mouth disease (FMD) virus (FMDV) circulates as multiple serotypes and strains in many regions of endemicity. In particular, the three Southern African Territories (SAT) serotypes are maintained effectively in their wildlife reservoir, the African buffalo, and individuals may harbor multiple SAT serotypes for extended periods in the pharyngeal region. However, the exact site and mechanism for persistence remain unclear. FMD in buffaloes offers a unique opportunity to study FMDV persistence, as transmission from carrier ruminants has convincingly been demonstrated for only this species. Following coinfection of naive African buffaloes with isolates of three SAT serotypes from field buffaloes, palatine tonsil swabs were the sample of choice for recovering infectious FMDV up to 400 days postinfection (dpi). Postmortem examination identified infectious virus for up to 185 dpi and viral genomes for up to 400 dpi in lymphoid tissues of the head and neck, focused mainly in germinal centers. Interestingly, viral persistencein vivowas not homogenous, and the SAT-1 isolate persisted longer than the SAT-2 and SAT-3 isolates. Coinfection and passage of these SAT isolates in goat and buffalo cell lines demonstrated a direct correlation between persistence and cell-killing capacity. These data suggest that FMDV persistence occurs in the germinal centers of lymphoid tissue but that the duration of persistence is related to virus replication and cell-killing capacity.IMPORTANCEFoot-and-mouth disease virus (FMDV) causes a highly contagious acute vesicular disease in domestic livestock and wildlife species. African buffaloes (Syncerus caffer) are the primary carrier hosts of FMDV in African savannah ecosystems, where the disease is endemic. We have shown that the virus persists for up to 400 days in buffaloes and that there is competition between viruses during mixed infections. There was similar competition in cell culture: viruses that killed cells quickly persisted more efficiently in passaged cell cultures. These results may provide a mechanism for the dominance of particular viruses in an ecosystem.

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