scholarly journals The population prevalence of Down’s syndrome in England and Wales in 2011

2013 ◽  
Vol 21 (9) ◽  
pp. 1016-1019 ◽  
Author(s):  
Jianhua Wu ◽  
Joan K Morris
Keyword(s):  
Down's Syndrome ◽  
Down’S Syndrome ◽  
England And Wales ◽  
Population Prevalence

scholarly journals Monitoring Trends in Prenatal Diagnosis of Down's Syndrome in England and Wales, 1989–92

1994 ◽  
Vol 1 (4) ◽  
pp. 233-237 ◽  
Author(s):  
Joan K Morris ◽  
David E Mutton ◽  
Roy Ide ◽  
Eva Alberman ◽  
Martin Bobrow
Keyword(s):  
Prenatal Diagnosis ◽  
Confidence Interval ◽  
Regional Differences ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Fold Increase ◽  
Maternal Serum ◽  
Serum Analysis ◽  
Chromosomal Anomalies ◽  
England And Wales

The national register of chromosomal anomalies that lead to Down's syndrome has enabled the monitoring of change in prenatal diagnosis for this condition, and the factors which affect the change. The proportion of cases of cytogenetically diagnosed Down's syndrome in England and Wales detected prenatally rose to 46% in 1991–2 from 31% in 1988–9, a 1·5-fold increase (95% confidence interval 1·3 to 1·7). The increase was confined to mothers under 40 years and was due to the introduction of screening by maternal serum analysis and ultrasound. Over a quarter of affected pregnancies in women aged 25–29 were detected prenatally in 1991–2 compared with less than 10% in 1988–9. Analysis of the data showed regional differences in prenatal diagnosis rates, and in the length of time elapsing between the diagnostic test and termination of an affected pregnancy. An inexplicable finding was that this period varied with the sex of the fetus, being on average a day longer for females than for males.

Population prevalence of Down's syndrome in the United Kingdom

2016 ◽  
Vol 60 (9) ◽  
pp. 874-878 ◽  
Author(s):  
M. Alexander ◽  
Y. Ding ◽  
N. Foskett ◽  
H. Petri ◽  
C. Wandel ◽  
...  
Keyword(s):  
United Kingdom ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
The United Kingdom ◽  
Population Prevalence

scholarly journals Reliability of Statistics on Down's Syndrome Notifications

1997 ◽  
Vol 4 (2) ◽  
pp. 95-97 ◽  
Author(s):  
T Huang ◽  
H C Watt ◽  
N J Wald ◽  
J K Morris ◽  
D Mutton ◽  
...  
Keyword(s):  
Maternal Age ◽  
Antenatal Diagnosis ◽  
Down's Syndrome ◽  
Age Distribution ◽  
Down’S Syndrome ◽  
England And Wales ◽  
Birth Prevalence ◽  
Live Births ◽  
National Statistics ◽  
Using Data

Objectives— To evaluate the completeness of notifications of Down's syndrome live births and terminations to the Office for National Statistics (ONS) using data from the National Down Syndrome Cytogenetic Register (NDSCR). To examine the agreement of observed birth prevalence of Down's syndrome with the expected birth prevalence derived from published maternal age specific rates. Methods— The number of live births (adjusted to allow for the estimated under-ascertainment) and the number of terminations due to fetal Down's syndrome from NDSCR were compared with those figures reported to the ONS. Subsequently, using the NDSCR figures, the live birth prevalence of Down's syndrome that would have occurred in the absence of antenatal diagnosis and selective termination was calculated in England and Wales in the years 1990–1993. These figures were compared with those derived by applying published age specific prevalences to the maternal age distribution in England and Wales. Results— It is estimated that only 48% and 46% respectively of Down's syndrome live births and terminations of pregnancy were notified to ONS between 1990 and 1993. The annual expected birth prevalences of Down's syndrome obtained by applying maternal age specific prevalences to the maternal age distribution were in close agreement with observed rates from NDSCR. Conclusions— There is considerable underreporting of Down's syndrome births and terminations to ONS. The NDSCR data are more complete and therefore the effects of screening should be monitored using data from this source, or using estimates derived from the age specific rates of Down's syndrome.

scholarly journals The trends in maternal age distribution and the estimated live birth and population prevalence of Down’s syndrome in China: 1985-2012

2021 ◽  
Author(s):  
Jing Kang ◽  
Jianhua Wu
Keyword(s):  
Live Birth ◽  
Maternal Age ◽  
National Level ◽  
Down's Syndrome ◽  
Age Distribution ◽  
Down’S Syndrome ◽  
Birth Prevalence ◽  
Live Births ◽  
The Past ◽  
Population Prevalence

ABSTRACTThis study aims to investigate the trends in maternal age distribution and estimate the live birth and population prevalence of Down’s syndrome in China.Using population survey data, we demonstrated the change of maternal age over the past three decades and its effect on the live birth prevalence of Down’s syndrome. We also integrated the live birth prevalence and the survival rate to estimate the population prevalence of Down’s syndrome. Chi-square test was used to compare the maternal age distributions across survey years.The results show that the maternal age has been rising over the past 30 years in China at national level. The proportion of mothers aged 35 and over increased from 3.62% in 1985 to 14.40% in 2010. The estimated live birth prevalence of Down’s syndrome has mirrored the same increase of the maternal age from 1.07 per 1000 live births in 1985 to 2.36 per 1000 live births in 2010. At City level, the change of maternal age and live birth prevalence of Down’s syndrome were more significant than at Town and County levels. The proportion of mothers aged 35 and over increased from 2.17% in 1995 to about 16% in 2010 at City level, while it increased from 2.03% to 13.65% at County level. The total estimated number of people with Down’s syndrome who were still alive in 2012 and aged below 27 was 611,053, and the estimated population prevalence is 0.45 per 1000.To conclude, this study provides a clear message about the rising trend in maternal age in both urban and rural areas in China since 1985 and its effect on the estimated birth prevalence with Down’s syndrome. The regional differences should be taken into account for planning population policy and allocating medical resources to reduce the burden of family with Down’s syndrome.

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