scholarly journals Characterization of cis-acting elements in the rat ATP citrate-lyase gene promoter

2002 ◽  
Vol 34 (1) ◽  
pp. 60-68 ◽  
Author(s):  
Young-An Moon ◽  
Sahng-Wook Park ◽  
Kyung-Sup Kim
Keyword(s):  
Gene Promoter ◽  
Atp Citrate Lyase ◽  
Cis Acting ◽  
Citrate Lyase

scholarly journals Identification and characterization of cis-acting elements conferring insulin responsiveness on hamster cholesterol 7α-hydroxylase gene promoter

2000 ◽  
Vol 347 (1) ◽  
pp. 147 ◽  
Author(s):  
Emma DE FABIANI ◽  
Maurizio CRESTANI ◽  
Maria MARRAPODI ◽  
Alessandra PINELLI ◽  
Viviana GOLFIERI ◽  
...  
Keyword(s):  
Gene Promoter ◽  
Cis Acting ◽  
Hydroxylase Gene ◽  
Insulin Responsiveness ◽  
Identification And Characterization

scholarly journals Characterization of regulatory elements on the promoter region of human ATP-citrate lyase

1999 ◽  
Vol 31 (2) ◽  
pp. 108-114 ◽  
Author(s):  
Young-Ah Moon ◽  
Kyung-Sup Kim ◽  
Un-Hyung Cho ◽  
Do-Jun Yoon ◽  
Sahng-Wook Park
Keyword(s):  
Promoter Region ◽  
Regulatory Elements ◽  
Atp Citrate Lyase ◽  
Citrate Lyase

scholarly journals Molecular Characterization of a Heteromeric ATP-Citrate Lyase That Generates Cytosolic Acetyl-Coenzyme A in Arabidopsis

2002 ◽  
Vol 130 (2) ◽  
pp. 740-756 ◽  
Author(s):  
Beth L. Fatland ◽  
Jinshan Ke ◽  
Marc D. Anderson ◽  
Wieslawa I. Mentzen ◽  
Li Wei Cui ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Coenzyme A ◽  
Atp Citrate Lyase ◽  
Acetyl Coenzyme A ◽  
Acetyl Coenzyme ◽  
Citrate Lyase

scholarly journals Molecular cloning and characterization of the ATP citrate lyase from carotenogenic yeastPhaffia rhodozyma

2015 ◽  
Vol 15 (6) ◽  
pp. fov054 ◽  
Author(s):  
Cipriano Chávez-Cabrera ◽  
Rodolfo Marsch ◽  
Yaneth Bartolo-Aguilar ◽  
Zoila Rosa Flores-Bustamante ◽  
María Eugenia Hidalgo-Lara ◽  
...  
Keyword(s):  
Molecular Cloning ◽  
Atp Citrate Lyase ◽  
Citrate Lyase

scholarly journals Insulin- and polyunsaturated fatty acid-responsive region(s) of rat ATP citrate-lyase gene promoter

FEBS Letters ◽  
1996 ◽  
Vol 380 (1-2) ◽  
pp. 204-207 ◽  
Author(s):  
Hitomi Fukuda ◽  
Nobuko Iritani ◽  
Akihiko Katsurada ◽  
Tamio Noguchi
Keyword(s):  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Gene Promoter ◽  
Atp Citrate Lyase ◽  
Citrate Lyase

scholarly journals Characterization of the p150,95 leukocyte integrin alpha subunit (CD11c) gene promoter. Identification of cis-acting elements.

1993 ◽  
Vol 268 (2) ◽  
pp. 1187-1193
Author(s):  
M. López-Cabrera ◽  
A. Nueda ◽  
A. Vara ◽  
J. García-Aguilar ◽  
A. Tugores ◽  
...  
Keyword(s):  
Gene Promoter ◽  
Alpha Subunit ◽  
Cis Acting

scholarly journals Reverse Genetic Characterization of Cytosolic Acetyl-CoA Generation by ATP-Citrate Lyase in Arabidopsis

2004 ◽  
Vol 17 (1) ◽  
pp. 182-203 ◽  
Author(s):  
Beth L. Fatland ◽  
Basil J. Nikolau ◽  
Eve Syrkin Wurtele
Keyword(s):  
Genetic Characterization ◽  
Reverse Genetic ◽  
Atp Citrate Lyase ◽  
Acetyl Coa ◽  
Citrate Lyase

scholarly journals Characterization of the human TARDBP gene promoter

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marco Baralle ◽  
Maurizio Romano
Keyword(s):  
Gene Promoter ◽  
Transcriptional Level ◽  
Developmentally Regulated ◽  
Cis Acting ◽  
Transcript Stability ◽  
Intron 1 ◽  
Main Component ◽  
Als Patients

AbstractThe expression of TDP-43, the main component of neuronal intracellular inclusions across a broad spectrum of ALS and FTD disorders, is developmentally regulated and studies in vivo have shown that TDP-43 overexpression can be toxic, even before observation of pathological aggregates. Starting from these observations, the regulation of its expression at transcriptional level might represent a further key element for the pathogenesis of neurodegenerative diseases. Therefore, we have characterized the human TARDBP promoter, in order to study the transcriptional mechanisms of expression. Mapping of cis-acting elements by luciferase assays in different cell outlined that the activity of the promoter seems to be higher in SH-SY5Y, Neuro2A, and HeLa than in HEK293. In addition, we tested effects of two SNPs found in the promoter region of ALS patients and observed no significant effect on transcription levels in all tested cell lines. Lastly, while TDP-43 overexpression did not affect significantly the activity of its promoter (suggesting that TDP-43 does not influence its own transcription), the presence of the 5′UTR sequence and of intron-1 splicing seem to impact positively on TDP-43 expression without affecting transcript stability. In conclusion, we have identified the region spanning nucleotides 451–230 upstream from the transcription start site as the minimal region with a significant transcription activity. These results lay an important foundation for exploring the regulation of the TARDBP gene transcription by exogenous and endogenous stimuli and the implication of transcriptional mechanisms in the pathogenesis of TDP-43 proteinopathies.

Sign in / Sign up

Export Citation Format

Share Document