Background and objectives:
Sesame oil supplementation reduces blood pressure and lipids in hypertensives. Rice bran oil exhibits good control over lipids. The current study examines how modest variations in blends of sesame and rice bran oils (80% physically refined high oryzanol rice bran oil and 20% unrefined sesame oil), rich in antioxidants and unsaturated fatty acids, intake may affect blood pressure and lipids in hypertensives.
Methods:
In this prospective, randomized, open-label dietary intervention, 300 hypertensive patients (mean age, 57 years; 160% men; 140% women) were equally randomized for 60 days to one of the three groups: 1) calcium channel blocker 30 mg/d; 2) sesame oil blend (Vivo
TM
) ; 3) sesame oil blend + calcium channel blocker 30mg/d. The patients except group 1 were supplied with sesame oil blend and instructed to use ∼35g of oil/day/person for cooking, salad preparation etc., Blood pressure was measured at baseline, and after 15, 30, 45 and 60 days, respectively. Lipid profile was measured at baseline and at the end of 60 days.
Results:
Calcium channel blocker or sesame oil blend or combination of calcium channel blocker and sesame oil blend induced significant fall of systolic/diastolic blood pressure [SBP -16.2mmHg, -14 mmHg and -36mmHg/DBP -12mmHg,-10.8mmHg and -23.8 mmHg, respectively vs baseline). Calcium channel blocker and sesame oil combination induced greater reduction and the dose of the drug was also reduced as there was remarkable fall in blood pressure. Total cholesterol, LDL cholesterol and triglycerides levels in the blood were significantly reduced while HDL cholesterol levels increased in sesame oil blend alone (18%, 26%, 12.6% and 9.5%, respectively vs baseline) or combination therapies (19.7%, 27%, 13.5% and 10.9% respectively, vs baseline).
Conclusion:
We have demonstrated, for the first time that dietary intervention with blends of sesame and rice bran oils lowers blood pressure and lipids in hypertensive individuals. Furthermore, our results suggest that the reduction of blood pressure and lipids will have important implications for population health and lowering the risk of stroke and ischaemic heart disease.
Effect of N- and T-type calcium channel blocker on proteinuria, blood pressure and kidney function in hypertensive patients: a meta-analysis
