P-Glycoprotein and Breast Cancer Resistance Protein Restrict Apical-to-Basolateral Permeability of Human Brain Endothelium to Amyloid-β
2009 ◽
Vol 29
(6)
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pp. 1079-1083
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Keyword(s):
The clearance of amyloid beta (Aβ) from the brain represents a novel therapeutic target for Alzheimer's disease. Conflicting data exist regarding the contribution of adenosine triphosphatebinding cassette transporters to the clearance of Aβ through the blood-brain barrier. Therefore, we investigated whether Aβ could be a substrate for P-glycoprotein (P-gp) and/or for breast cancer resistance protein (BCRP) using a human brain endothelial cell line, hCMEC/D3. Inhibition of P-gp and BCRP increased apical-to-basolateral, but not basolateral-to-apical, permeability of hCMEC/D3 cells to 125l Aβ 1–40. Our in vitro data suggest that P-gp and BCRP might act to prevent the blood-borne Aβ 1–40 from entering the brain.
2018 ◽
Vol 107
(8)
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pp. 2225-2235
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2010 ◽
Vol 333
(3)
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pp. 788-796
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Keyword(s):
Keyword(s):
2013 ◽
Vol 710
(1-3)
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pp. 20-28
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2007 ◽
Vol 13
(21)
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pp. 6440-6449
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2017 ◽
Vol 45
(12)
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pp. 1282-1291
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Keyword(s):
Keyword(s):