scholarly journals Regional citrate anticoagulation for continuous arteriovenous hemodialysis in critically ill patients

1990 ◽  
Vol 38 (5) ◽  
pp. 976-981 ◽  
Author(s):  
Ravindra L. Mehta ◽  
Brian R. Mcdonald ◽  
May M. Aguilar ◽  
David M. Ward
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Regional Citrate Anticoagulation ◽  
Citrate Anticoagulation

scholarly journals Low bicarbonate replacement fluid normalizes metabolic alkalosis during continuous veno-venous hemofiltration with regional citrate anticoagulation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Paul Köglberger ◽  
Sebastian J. Klein ◽  
Georg Franz Lehner ◽  
Romuald Bellmann ◽  
Andreas Peer ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Metabolic Alkalosis ◽  
Base Excess ◽  
Kidney Injury ◽  
Regional Citrate Anticoagulation ◽  
Citrate Anticoagulation ◽  
Future Studies ◽  
Replacement Fluid ◽  
Retrospective Comparative Study

Abstract Background Metabolic alkalosis is a frequently occurring problem during continuous veno-venous hemofiltration (CVVH) with regional citrate anticoagulation (RCA). This study aimed to evaluate the effectiveness of switching from high to low bicarbonate (HCO3−) replacement fluid in alkalotic critically ill patients with acute kidney injury treated by CVVH and RCA. Methods A retrospective-comparative study design was applied. Patients who underwent CVVH with RCA in the ICU between 09/2016 and 11/2017 were evaluated. Data were available from the clinical routine. A switch of the replacement fluid Phoxilium® (30 mmol/l HCO3−) to Biphozyl® (22 mmol/l HCO3−) was performed as blood HCO3− concentration persisted ≥ 26 mmol/l despite adjustments of citrate dose and blood flow. Data were collected from 72 h before the switch of the replacement solutions until 72 h afterwards. Results Of 153 patients treated with CVVH during that period, 45 patients were switched from Phoxilium® to Biphozyl®. Forty-two patients (42 circuits) were available for statistical analysis. After switching the replacement fluid from Phoxilium® to Biphozyl® the serum HCO3− concentration decreased significantly from 27.7 mmol/l (IQR 26.9–28.9) to 25.8 mmol/l (IQR 24.6–27.7) within 24 h (p < 0.001). Base excess (BE) decreased significantly from 4.0 mmol/l (IQR 3.1–5.1) to 1.8 mmol/l (IQR 0.2–3.4) within 24 h (p < 0.001). HCO3− and BE concentration remained stable from 24 h till the end of observation at 72 h after the replacement fluid change (p = 0.225). pH and PaCO2 did not change significantly after the switch of the replacement fluid until 72 h. Conclusions This retrospective analysis suggests that for patients developing refractory metabolic alkalosis during CVVH with RCA the use of Biphozyl® reduces external HCO3− load and sustainably corrects intracorporeal HCO3− and BE concentrations. Future studies have to prove whether correcting metabolic alkalosis during CVVH with RCA in critically ill patients is of relevance in terms of clinical outcome.

Regional Citrate Anticoagulation Reduces Polymorphonuclear Cell Degranulation in Critically Ill Patients Treated With Continuous Venovenous Hemofiltration

2011 ◽  
Vol 15 (6) ◽  
pp. 556-564 ◽  
Author(s):  
Khajohn Tiranathanagul ◽  
Onanong Jearnsujitwimol ◽  
Paweena Susantitaphong ◽  
Narin Kijkriengkraikul ◽  
Asada Leelahavanichkul ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Regional Citrate Anticoagulation ◽  
Continuous Venovenous Hemofiltration ◽  
Polymorphonuclear Cell ◽  
Citrate Anticoagulation

scholarly journals Regional Citrate Anticoagulation for RRTs in Critically Ill Patients with AKI

2014 ◽  
Vol 9 (12) ◽  
pp. 2173-2188 ◽  
Author(s):  
Santo Morabito ◽  
Valentina Pistolesi ◽  
Luigi Tritapepe ◽  
Enrico Fiaccadori
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Regional Citrate Anticoagulation ◽  
Citrate Anticoagulation
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