Analysis of the cDNA sequence encoding MHC-Aβ in tubular epithelium from mouse kidney

AbstractBased on the cDNA sequence encoding taxane 2α-O-benzoyltransferase (TBT) from Taxus yunnanensis (Gen-Bank Accession No.: AY970522), genomic sequences of TBTs from T. yunnanensis (TyTBT) and T. cuspidata (TcuTBT) were cloned for the first time. They both contain only one intron. The finding that the introns of TyTBT and TcuTBT are more diverse than their exons implies that the gene diversity is more within introns than within exons, which may be important for keeping the functions of the genes.

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Partial cDNA sequence encoding a nuclear pore protein modified by O-linked N-acetylglucosamine.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.85.24.9595 ◽

1988 ◽

Vol 85 (24) ◽

pp. 9595-9599 ◽

Cited By ~ 43

Author(s):

M. D'Onofrio ◽

C. M. Starr ◽

M. K. Park ◽

G. D. Holt ◽

R. S. Haltiwanger ◽

...

Keyword(s):

Cdna Sequence ◽

Nuclear Pore ◽

Nuclear Pore Protein ◽

Partial Cdna Sequence ◽

Partial Cdna ◽

Sequence Encoding ◽

Pore Protein

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Molecular cloning of a cDNA sequence encoding a trophectoderm-specific marker during mouse blastocyst formation.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.79.7.2328 ◽

1982 ◽

Vol 79 (7) ◽

pp. 2328-2332 ◽

Cited By ~ 17

Author(s):

P. Brulet ◽

F. Jacob

Keyword(s):

Molecular Cloning ◽

Cdna Sequence ◽

Specific Marker ◽

Blastocyst Formation ◽

Mouse Blastocyst ◽

Sequence Encoding

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Complete cDNA sequence encoding human β-galactoside α-2, 6-sialyltransferase

Nucleic Acids Research ◽

10.1093/nar/18.3.667 ◽

1990 ◽

Vol 18 (3) ◽

pp. 667-667 ◽

Cited By ~ 93

Author(s):

Ulrich Grundmann ◽

Claudia Nerlich ◽

Thomas Rein ◽

Gerd Zettlmeissl

Keyword(s):

Cdna Sequence ◽

Sequence Encoding

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Two parallel prothrombin activator systems in Australian rough-scaled snake, Tropidechis carinatus

Thrombosis and Haemostasis ◽

10.1160/th04-07-0435 ◽

2005 ◽

Vol 93 (01) ◽

pp. 40-47 ◽

Cited By ~ 14

Author(s):

Md. Abu Reza ◽

Sanjay Swarup ◽

Manjunatha Kini

Keyword(s):

Blood Coagulation ◽

Blood Clotting ◽

Cdna Sequence ◽

Factor Xa ◽

Coagulation Factor ◽

Venom Gland ◽

Factor X ◽

Specific Expression ◽

Life Saving ◽

Sequence Encoding

SummaryIt is uncommon for similar pathways/systems to be involved in highly divergent functions within single organisms. Earlier, we have shown that trocarin D, a venom prothrombin activator, from the Australian rough-scaled snake Tropidechis carinatus, is structurally and functionally similar to the blood coagulation factor Xa (FXa). The presence of a haemostatic system in these snakes implies that they have two parallel prothrombin activating systems: one in the plasma, that participates in the life saving process of blood clotting and the other in their venom, where it acts as a toxin. Here, we report the complete cDNA sequence encoding the blood coagulation factor X (FX) from the liver of T. carinatus. Deduced T. carinatus FX sequence shows ~80% identity with trocarin D but ~50% identity with the mammalian FX. Our present study confirms the presence of two separate genes – one each for FX and trocarin D, that code for similar proteins in T. carinatus snake. These two genes have different expression sites and divergent uses suggesting that snake venom prothrombin activators have probably evolved by the duplication of the liver FX gene and subsequently marked for tissue-specific expression in the venom gland.

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