scholarly journals Prognostic value of monitoring a candidate immunophenotypic leukaemic stem/progenitor cell population in patients allografted for acute myeloid leukaemia

Leukemia ◽  
2014 ◽  
Vol 29 (4) ◽  
pp. 988-991 ◽  
Author(s):  
C Bradbury ◽  
A E Houlton ◽  
S Akiki ◽  
R Gregg ◽  
M Rindl ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Cell Population ◽  
Prognostic Value ◽  
Progenitor Cell ◽  
Progenitor Cell Population ◽  
Acute Myeloid

scholarly journals Normal myeloid progenitor cell subset-associated gene signatures for acute myeloid leukaemia subtyping with prognostic impact

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0229593 ◽  
Author(s):  
Anna A. Schönherz ◽  
Julie Støve Bødker ◽  
Alexander Schmitz ◽  
Rasmus Froberg Brøndum ◽  
Lasse Hjort Jakobsen ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Progenitor Cell ◽  
Cell Subset ◽  
Prognostic Impact ◽  
Gene Signatures ◽  
Myeloid Progenitor ◽  
Myeloid Progenitor Cell ◽  
Acute Myeloid

Cytogenetics and their prognostic value in de novo acute myeloid leukaemia: a report on 283 cases

1989 ◽  
Vol 73 (1) ◽  
pp. 61-67 ◽  
Author(s):  
P. Fenaux ◽  
C. Preudhomme ◽  
J. L. Laï ◽  
P. Morel ◽  
R. Beuscart ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Prognostic Value ◽  
De Novo ◽  
Acute Myeloid

scholarly journals Absence of leukaemic CD34+cells in acute myeloid leukaemia is of high prognostic value: a longstanding controversy deciphered

2015 ◽  
Vol 171 (2) ◽  
pp. 227-238 ◽  
Author(s):  
Wendelien Zeijlemaker ◽  
Angèle Kelder ◽  
Rolf Wouters ◽  
Peter J.M. Valk ◽  
Birgit I. Witte ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Prognostic Value ◽  
Cd34 Cells ◽  
Acute Myeloid

scholarly journals Wnt Signalling in Acute Myeloid Leukaemia

Cells ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 1403 ◽  
Author(s):  
Alicja M. Gruszka ◽  
Debora Valli ◽  
Myriam Alcalay
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Prognostic Value ◽  
Clinical Trial Data ◽  
Trial Data ◽  
Wnt Signalling ◽  
Preclinical Studies ◽  
Malignant Diseases ◽  
Haematopoietic System ◽  
Acute Myeloid

Acute myeloid leukaemia (AML) is a group of malignant diseases of the haematopoietic system. AML occurs as the result of mutations in haematopoietic stem/progenitor cells, which upregulate Wnt signalling through a variety of mechanisms. Other mechanisms of Wnt activation in AML have been described such as Wnt antagonist inactivation through promoter methylation. Wnt signalling is necessary for the maintenance of leukaemic stem cells. Several molecules involved in or modulating Wnt signalling have a prognostic value in AML. These include: β-catenin, LEF-1, phosphorylated-GSK3β, PSMD2, PPARD, XPNPEP, sFRP2, RUNX1, AXIN2, PCDH17, CXXC5, LLGL1 and PTK7. Targeting Wnt signalling for tumour eradication is an approach that is being explored in haematological and solid tumours. A number of preclinical studies confirms its feasibility, albeit, so far no reliable clinical trial data are available to prove its utility and efficacy.

Prognostic value of dysmyelopoietic features in de novo acute myeloid leukaemia: a report on 132 patients

2008 ◽  
Vol 12 (1) ◽  
pp. 57-65 ◽  
Author(s):  
M. H. ESTIENNE ◽  
P. FENAUX ◽  
C. PREUDHOMME ◽  
J. L. LAI ◽  
M. ZANDECKI ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Prognostic Value ◽  
De Novo ◽  
Acute Myeloid

Involvement of a common progenitor cell in core binding factor acute myeloid leukaemia associated with mastocytosis

2012 ◽  
Vol 36 (11) ◽  
pp. 1330-1333 ◽  
Author(s):  
Edouard Cornet ◽  
Florent Dumézy ◽  
Christophe Roumier ◽  
Pascale Lepelley ◽  
Nathalie Jouy ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Progenitor Cell ◽  
Core Binding Factor ◽  
Binding Factor ◽  
Acute Myeloid

Prognostic value of bone marrow MUC4 expression in acute myeloid leukaemia

2020 ◽  
Vol 77 (4) ◽  
pp. 202-207
Author(s):  
AS Abdelhady ◽  
FF Abdel Hamid ◽  
NM Hassan ◽  
DM Ibrahim
Keyword(s):  
Bone Marrow ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Prognostic Value ◽  
Muc4 Expression ◽  
Acute Myeloid

scholarly journals Progenitor cell involvement is predictive of response to induction chemotherapy in paediatric acute myeloid leukaemia

2003 ◽  
Vol 123 (3) ◽  
pp. 431-435 ◽  
Author(s):  
Donna L. Johnston ◽  
Soheil Meshinchi ◽  
Kent E. Opheim ◽  
Maria G. Pallavicini ◽  
James Feusner ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Induction Chemotherapy ◽  
Progenitor Cell ◽  
Acute Myeloid
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