scholarly journals Testicular mixed germ cell tumors: a morphological and immunohistochemical study using stem cell markers, OCT3/4, SOX2 and GDF3, with emphasis on morphologically difficult-to-classify areas

2009 ◽  
Vol 22 (8) ◽  
pp. 1066-1074 ◽  
Author(s):  
Anuradha Gopalan ◽  
Deepti Dhall ◽  
Semra Olgac ◽  
Samson W Fine ◽  
James E Korkola ◽  
...  
Keyword(s):  
Stem Cell ◽  
Germ Cell ◽  
Immunohistochemical Study ◽  
Germ Cell Tumors ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Mixed Germ Cell Tumors

Immunohistochemical expression of cancer stem cell markers OCT3/4, NANOG, DPPA4, and CCND2 in testicular germ cell tumors.

2012 ◽  
Vol 30 (5_suppl) ◽  
pp. 333-333 ◽  
Author(s):  
Ravendra Ryan Moniz ◽  
Walter Henriques Costa ◽  
Victor Soares Fanni ◽  
Isabela Werneck Cunha ◽  
Rafael Malagoli Rocha ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Germ Cell ◽  
Germ Cell Tumors ◽  
Stem Cell Markers ◽  
Testicular Germ Cell Tumors ◽  
Immunohistochemical Expression ◽  
Testicular Germ Cell ◽  
Cell Markers ◽  
Cancer Stem Cell Markers

333 Background: The purpose of this study was to examine the immunohistochemical expression of OCT3/4, CCND2, DPPA4 and NANOG in primary non-seminomatous germ cell testicular tumors that might be associated with different entities of germ cell tumors. OCT3/4, NANOG, DPPA4 and CCND2 have been identified as key regulators of pluripotency in mammalian embryonic and induced stem cells. Methods: Tissue samples of non seminoma testicular germ cell tumors including carcinoma in situ (CIS, n=10), seminoma component (n=5), embryonic carcinoma (n=20), mature teratoma (n= 7), immature teratoma (n=7), yolk sac tumor (n=5) and choriocarcinoma (n=3) were first analyzed by histological evaluation followed by selection of the appropriate tissue sections prepared from paraffin embedded testicular tissue blocks fixed with buffered formalin. To investigate immunohistochemical expression, of cancer stem cell markers samples tissues were analyzed under central pathological evaluation. Results: In CIS cells all markers were detected with a strong immunohistochemical expression suggesting that CIS cells maintain characteristics of embryonic stem cells. The invasive tumor samples, in comparison, showed a more heterogeneous expression pattern of OCT3/4, NANOG, DPPA4 and CCND2. There was an abundant expression in seminomas and embryonic carcinomas compared to a marked reduction expression in choriocarcinoma and teratomas. The expression of the markers was related to tumoral tissue differentiation. The seminomatous component and the embryonic carcinoma and undifferentiated tissues such as intratubular neoplasia presented elevated expressions. Specialized tissues such as teratoma and choriocarcinoma present low expression levels or absence of studied markers. The teratomatous subtypes do not express NANOG. The sub-type coriocarcinoma tumors do not express CCND2 and NANOG. Conclusions: The immunohistochemical expression of stem cell markers OCT3/4, NANOG, DPPA4 and CCND2 follow a specific pattern that is related to tumoral differentiation and consequent loss of pluripotency characteristics.

Diagnostic Utility of Novel Stem Cell Markers SALL4, OCT4, NANOG, SOX2, UTF1, and TCL1 in Primary Mediastinal Germ Cell Tumors

2010 ◽  
Vol 34 (5) ◽  
pp. 697-706 ◽  
Author(s):  
Aijun Liu ◽  
Liang Cheng ◽  
Jun Du ◽  
Yan Peng ◽  
Robert W. Allan ◽  
...  
Keyword(s):  
Stem Cell ◽  
Germ Cell ◽  
Germ Cell Tumors ◽  
Diagnostic Utility ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Mediastinal Germ Cell Tumors

scholarly journals Immunohistochemical study of hepatocyte, cholangiocyte and stem cell markers of hepatocellular carcinoma: the second report: relationship with tumor size and cell differentiation

2016 ◽  
Vol 23 (7) ◽  
pp. 414-421 ◽  
Author(s):  
Arisa Kumagai ◽  
Fukuo Kondo ◽  
Keiji Sano ◽  
Masafumi Inoue ◽  
Takeshi Fujii ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Tumor Size ◽  
Immunohistochemical Study ◽  
Stem Cell Markers ◽  
Cell Markers

OP0015 Immunohistochemical study of stem cell markers ALDH1 and BRCA1 in breast cancer

2014 ◽  
Vol 50 ◽  
pp. e6
Author(s):  
H. Hosni ◽  
S. Dawood ◽  
A. Bassam
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Immunohistochemical Study ◽  
Stem Cell Markers ◽  
Cell Markers

Cancer stem cell markers in prostate cancer: an immunohistochemical study of ALDH1, SOX2 and EZH2

Pathology ◽  
2015 ◽  
Vol 47 (7) ◽  
pp. 622-628 ◽  
Author(s):  
Admire Matsika ◽  
Bhuvana Srinivasan ◽  
Christopher Day ◽  
Sabrina Ann Mader ◽  
Deirdre Margaret Kiernan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Immunohistochemical Study ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Cancer Stem Cell Markers

Immunohistochemical study of hepatocyte, cholangiocyte and stem cell markers of hepatocellular carcinoma

2011 ◽  
Vol 18 (4) ◽  
pp. 537-543 ◽  
Author(s):  
Makoto Shibuya ◽  
Fukuo Kondo ◽  
Keiji Sano ◽  
Tadahiro Takada ◽  
Takehide Asano
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cell ◽  
Immunohistochemical Study ◽  
Stem Cell Markers ◽  
Cell Markers

scholarly journals Stem Cell Markers, Nestin, and CD133 are Markers of Aggressive Behavior in Astrocytic Tumors: An Immunohistochemical Study in Egyptian Population

2014 ◽  
Vol 142 (suppl_1) ◽  
pp. A002-A002
Author(s):  
Mohamed Shareef ◽  
Rania Wasfy ◽  
Hend Abu Safia ◽  
Karima Marey
Keyword(s):  
Stem Cell ◽  
Aggressive Behavior ◽  
Immunohistochemical Study ◽  
Stem Cell Markers ◽  
Astrocytic Tumors ◽  
Cell Markers ◽  
Egyptian Population
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