scholarly journals Heterogeneity of ERBB2 amplification in adenocarcinoma, squamous cell carcinoma and large cell undifferentiated carcinoma of the lung

2012 ◽  
Vol 25 (12) ◽  
pp. 1566-1573 ◽  
Author(s):  
Tobias J Grob ◽  
Ivonne Kannengiesser ◽  
Maria C Tsourlakis ◽  
Djordje Atanackovic ◽  
Alexandra M Koenig ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Large Cell ◽  
Undifferentiated Carcinoma ◽  
Erbb2 Amplification

Cervical nodal metastases from occult primary: Undifferentiated carcinoma versus squamous cell carcinoma

Head & Neck ◽  
2002 ◽  
Vol 24 (4) ◽  
pp. 361-369 ◽  
Author(s):  
Chi-Chung Tong ◽  
Mai-Yee Luk ◽  
Sin-Ming Chow ◽  
Kai-Cheong Ngan ◽  
Wai-Hon Lau
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Undifferentiated Carcinoma ◽  
Nodal Metastases

scholarly journals Carcinoma of Vagina in Utero-Vaginal Prolapse: A Rare Presentation

2012 ◽  
Vol 52 (186) ◽  
Author(s):  
S Acharya ◽  
DK Uprety
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histopathological Examination ◽  
Large Cell ◽  
Uterovaginal Prolapse ◽  
Rare Entity ◽  
Rare Presentation ◽  
Vaginal Carcinoma ◽  
Keywords Squamous Cell Carcinoma

Primary vaginal carcinoma in uterovaginal prolapse is a rare entity. We report a case of an 84-years-old lady, who presented with long standing vaginal ulcer in association with third degree uterovaginal prolapse. Incisional biopsy was taken from the ulcer. Histopathological examination showed a large cell keratinizing squamous cell carcinoma. Keywords: Squamous cell carcinoma, uterovaginal prolapse, vaginal carcinoma.

Prognostic Value of Squamous Cell Carcinoma Antigen in Patients with Uterine Cervical Carcinoma

1988 ◽  
Vol 74 (2) ◽  
pp. 221-225 ◽  
Author(s):  
Jyotsna M. Bhatavdekar ◽  
Nandita Ghosh ◽  
Minakshi K. Shukla ◽  
Damodar B. Balar ◽  
Anita Bhaduri ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cervical Carcinoma ◽  
Squamous Cell ◽  
Large Cell ◽  
Diagnostic Value ◽  
Squamous Cell Carcinoma Antigen ◽  
Histologic Subtype ◽  
Uterine Cervical Carcinoma ◽  
Highly Correlated

Squamous cell carcinoma antigen (SCC Ag) was estimated in 30 controls, in 16 patients with benign lesions of the uterine cervix, and in 51 patients with uterine cervical carcinoma. The rate of positivity of the antigen among the cancer patients was 87% (N = 49). SCC Ag estimations were of no diagnostic value, since 37% of patients with bening lesions had elevated levels compared to controls. SCC Ag was highly correlated to histologic subtype. The highest values were obtained in keratinizing tumors, followed by large cell nonkeratinizing and small cell nonkeratinizing types. Moreover, elevation of SCC Ag was statistically significant (p < 0.001) among all the three histologic subtypes compared to controls. However, SCC Ag levels were not consistently correlated to the stage of the disease. Patients with pretherapeutic SCC Ag levels above 30 ng/ml had a faster recurrence rate and shorter survival than those who exhibited antigen values below 2.0 ng/ml. From our results, it is suggested that SCC Ag has limited use as a parameter for early diagnosis of cervical carcinoma, but it seems to reflect advancement of the disease. These findings indicate that SCC Ag elevation may prove to be a valuable marker in predicting subclinical disease.

Proposal for a New Histopathological Classification of the Carcinomas of the Nasopharynx

1978 ◽  
Vol 64 (5) ◽  
pp. 513-518 ◽  
Author(s):  
Christian Micheau ◽  
Franco Rilke ◽  
Silvana Pilotti
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Classification Scheme ◽  
Malignant Tumors ◽  
Undifferentiated Carcinoma ◽  
New Classification ◽  
Histopathological Classification ◽  
Potential Origin

A new classification scheme for malignant tumors of the nasopharynx is proposed in which the undifferentiated carcinoma of nasopharyngeal types as a prominent position. This term replaces the previous obsolete term lymphoepithelioma on the basis of its clinicopathologic identity, its separation from squamous cell carcinoma, and its potential origin from anatomical areas other than the nasopharynx.

Pulmonary Large Cell Carcinoma Lacking Squamous Differentiation Is Clinicopathologically Indistinguishable From Solid-Subtype Adenocarcinoma

2013 ◽  
Vol 138 (5) ◽  
pp. 626-635 ◽  
Author(s):  
David H. Hwang ◽  
David P. Szeto ◽  
Anthony S. Perry ◽  
Jacqueline L. Bruce ◽  
Lynette M. Sholl
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Features ◽  
Squamous Cell ◽  
Lung Tumor ◽  
Neuroendocrine Differentiation ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
World Health ◽  
Thyroid Transcription Factor 1

Context Pulmonary large cell carcinoma (LCC) includes tumors not readily diagnosed as adenocarcinoma (ADC) or squamous cell carcinoma on morphologic grounds, without regard to immunophenotype, according to the World Health Organization (WHO). This ambiguous designation may cause confusion over selection of mutation testing and directed therapies. Several groups have proposed the use of immunohistochemistry (IHC) to recategorize LCC as ADC or squamous cell carcinoma; however, it remains unclear if strictly defined LCCs are a clinicopathologically distinct lung tumor subset. Objective —To compare the pathologic, molecular, and clinical features of 2 morphologically similar tumors: solid-subtype ADC and LCC. Design Tumors were included on the basis of solid growth pattern; tumors with squamous or neuroendocrine differentiation were excluded. Solid ADC (n = 42) and LCC (n = 57) were diagnosed by using WHO criteria (5 intracellular mucin droplets in ≥2 high-power fields for solid ADC) and tested for KRAS, EGFR, and ALK alterations. Results —Both solid ADC and LCC groups were dominated by tumors with “undifferentiated”-type morphology and both had a high frequency of thyroid transcription factor 1 expression. KRAS was mutated in 38% of solid ADCs versus 43% of LCCs (P = .62). One ALK-rearranged and 1 EGFR-mutated tumor were detected in the solid ADC and LCC groups, respectively. There were no significant differences in clinical features or outcomes; the prevalence of smoking in both groups was greater than 95%. Conclusions Other than a paucity of intracellular mucin, LCC lacking squamous or neuroendocrine differentiation is indistinguishable from solid-subtype ADC. We propose the reclassification of these tumors as mucin-poor solid adenocarcinomas.

scholarly journals Synchronous Occurrence of Primary Cutaneous Anaplastic Large Cell Lymphoma and Squamous Cell Carcinoma

2016 ◽  
Vol 28 (4) ◽  
pp. 491 ◽  
Author(s):  
Ji-Hye Park ◽  
Jae Ho Lee ◽  
Youngkyoung Lim ◽  
You Jin Lee ◽  
Dong-Youn Lee
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Anaplastic Large Cell Lymphoma ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Large Cell Lymphoma

Basaloid Squamous Cell Carcinoma of the Esophagus a Case Report

2005 ◽  
Vol 91 (1) ◽  
pp. 87-89 ◽  
Author(s):  
Miroslav Bekavac-Bešlin ◽  
August Mijić ◽  
Aljoša Matejčić ◽  
Željko Ferenčić
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Undifferentiated Carcinoma ◽  
Endoscopic Biopsy ◽  
Esophageal Wall ◽  
Basaloid Squamous Cell Carcinoma ◽  
Surgical Specimen ◽  
Carcinoma Of The Esophagus ◽  
Basaloid Squamous

Basaloid squamous cell carcinoma (BSCC) of the esophagus is an extremely rare tumor which should be differentiated from adenoid cystic and small cell undifferentiated carcinoma. We present the case of a 48-year-old male patient with esophageal BSCC. This tumor has specific histological features which may be difficult to recognize by small endoscopic biopsy examination. In our patient the surgical specimen revealed BSCC with an aggressive pattern (invasion of the whole esophageal wall thickness, lymph node metastases and intraneural spread). We proposed chemotherapy and radiotherapy after surgery, which resulted in a survival of 17 months.

Sign in / Sign up

Export Citation Format

Share Document