scholarly journals Classic lobular neoplasia on core biopsy: a clinical and radio-pathologic correlation study with follow-up excision biopsy

2013 ◽  
Vol 26 (6) ◽  
pp. 762-771 ◽  
Author(s):  
Shweta Chaudhary ◽  
Loretta Lawrence ◽  
Geraldine McGinty ◽  
Karen Kostroff ◽  
Tawfiqul Bhuiya
Keyword(s):  
Core Biopsy ◽  
Correlation Study ◽  
Lobular Neoplasia ◽  
Excision Biopsy ◽  
Pathologic Correlation

Invasive Mammary Carcinoma After Immediate and Short-Term Follow-up for Lobular Neoplasia on Core Biopsy

2003 ◽  
Vol 27 (3) ◽  
pp. 325-333 ◽  
Author(s):  
Giovanna Maria Crisi ◽  
Srinivas Mandavilli ◽  
Edward Cronin ◽  
Andrew Ricci,
Keyword(s):  
Mammary Carcinoma ◽  
Core Biopsy ◽  
Lobular Neoplasia ◽  
Short Term ◽  
Invasive Mammary Carcinoma

scholarly journals Outcome of radial scar/complex sclerosing lesion associated with epithelial proliferations with atypia diagnosed on breast core biopsy – Results from a multicentric UK based study

2019 ◽  
Author(s):  
Emad Rakha ◽  
Francisco Beca ◽  
Mariangela D'Andrea ◽  
Areeg Abbas ◽  
William Petrou-Nunn ◽  
...  
Keyword(s):  
Core Biopsy ◽  
Invasive Carcinoma ◽  
Surgical Excision ◽  
Lobular Neoplasia ◽  
Radial Scar ◽  
Complex Sclerosing Lesion ◽  
Ductal Hyperplasia ◽  
Epithelial Atypia

AIMS: The clinical significance of radial scar/complex sclerosing lesion (RS/CSL) with high risk lesions (epithelial atypia) diagnosed on needle core biopsy (NCB) is not well defined. We aimed at assessing the upgrade rate to carcinoma in-situ (DCIS) and invasive on the surgical excision specimen in a large cohort of RS/CSL associated with atypia. METHODS: 161 women with NCB diagnosis of a RS/CSL with atypia and follow-up histology were studied. Histological findings including different forms of the atypical lesions and final histological outcome in the excision specimens were retrieved and analysed and the upgrade rate for malignancy and invasive carcinoma calculated. RESULTS: 76% of the cases were associated with an atypical ductal hyperplasia (ADH) whereas lobular neoplasia was seen in 24%. On final histology 38 cases were malignant (overall upgrade rate of 25%); 12 invasive and 27 DCIS. The upgrade differed according to the type of atypia and was highest for ADH (35%). When associated with lobular neoplasia the upgrade rate was 12%. The upgrade rates variability was also considerably lower and showing less variability when considering the upgrade to invasive carcinoma alone. CONCLUSION: The upgrade rate for ADH diagnosed on NCB with RS is similar to that of ADH without RS and therefore should be managed similarly. RS associated with LN is less frequently associated with malignant outcome. Most lesions exhibiting some degree of atypia showed similar upgrade rate to invasive carcinoma. Management of RS should be based on the concurrent atypical lesion.

scholarly journals Breast Leiomyosarcoma: A Systematic Review and Recommendations for Management

2019 ◽  
Vol 104 (5-6) ◽  
pp. 196-202
Author(s):  
Mohammed Iyoob Mohammed Ilyas ◽  
Sharique Nazir ◽  
Philip Q. Xiao
Keyword(s):  
Systematic Review ◽  
Core Biopsy ◽  
Residual Tumor ◽  
Left Breast ◽  
Excision Biopsy ◽  
Skin Involvement ◽  
Breast Parenchyma ◽  
Outer Quadrant ◽  
Simple Mastectomy

Background Leiomyosarcomas of breast are very rare tumors, with only 54 cases reported in the literature to date. Methods We report a case of leiomyosarcoma in a 52-year-old woman who presented with a painless left breast mass in the upper outer quadrant of her left breast. It measured about 6 cm in diameter and was located within the breast parenchyma with no skin involvement. Mammogram was suggestive of BI-RADS IV lesion, and core biopsy of the lesion was inconclusive. Results Histopathology and immunohistochemistry of the excision biopsy of the mass confirmed the diagnosis of leiomyosarcoma approaching the specimen margins. The patient underwent simple mastectomy, which did not reveal any residual tumor or additional lesions. Follow-up for a year after her mastectomy did not show any local or systemic recurrence. Conclusions We reviewed the literature and summarize our findings as recommendations for management of leiomyosarcoma of breast.

scholarly journals Pathologic Findings of Follow-up Surgical Excision for Lobular Neoplasia on Breast Core Biopsy Performed for Calcification

2012 ◽  
Vol 138 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Chengquan Zhao ◽  
Mohamed Mokhtar Desouki ◽  
Anca Florea ◽  
Khaled Mohammed ◽  
Xin Li ◽  
...  
Keyword(s):  
Core Biopsy ◽  
Surgical Excision ◽  
Lobular Neoplasia ◽  
Pathologic Findings

Intracerebral Hematoma, Perihemorrhagic Edema and Urinary Excreted Cysteinyl Leukotrienes Correlation Study

2014 ◽  
Vol 68 (2) ◽  
pp. 85-88
Author(s):  
Natalija Dolnenec-Baneva ◽  
Dijana Nikodijevic ◽  
Gordana Kiteva-Trenchevska ◽  
Igor Petrov ◽  
Dragana Petrovska-Cvetkovska ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Brain Edema ◽  
Correlation Study ◽  
Intracerebral Hematoma ◽  
Moderate Correlation ◽  
Hematoma Volume ◽  
Cysteinyl Leukotrienes ◽  
Edema Volume ◽  
Perihemorrhagic Edema

AbstractIntroduction.Several mechanisms in formation of perihemorrhagic edema are activated after contact of brain tissue-extravasated blood in intracerebral hemorrhage. Cysteinyl leukotrienes (cysLT) (C4, D4, E4) are included in this process as significant edema factors and they determine the neurological deficit and outcome. The study aim was a 5-day follow-up (admission/3 day/5 day) of urinary cysLT, hematoma volume, edema volume values and their correlation in patients after spontaneous, primary supratentorial intracerebral hemorrhage.Methods.An enzyme immunoassay was used for urinary cysLT measured in 62 patients and 80 healthy controls. Hematoma and edema volumes were visualized and measured by computed tomography and mathematically calculated with a special spheroid shape formula (V=AxBxC/2).Results.CysLT of hemorrhagic patients (1842.20±1413.2, 1181.54±906.2, 982.30±774.2pg/ml/mg creatinine) were significantly excreted (p<0.01). Brain edema (12.86±13.5, 22.38±21.1, 28.45±29.4cm3) was significantly increased (p<0.01). Hematoma volume values (13.05±14.5, 13.13±14.7, 12.99±14.7cm3) were not significant (p>0.05). A high correlation (multiple regression) between cysLT, hematoma and edema was found on the 3rdday (R=0.6) and a moderate correlation at admission (R=0.3) and on the 5thday (R=0.3).Conclusion.In our 5-day follow-up study a significant cysLT brain synthesis and significant brain edema progression versus constant hematoma volume values in hemorrhagic patients was found. A high correlation between cysLT, hematoma and edema volume was found on the 3rdday, a moderate correlation on admission and on the 5thday, which means that high cysLT and hematoma values were associated with high/moderate edema values.

Accelerated Cardiac Allograft Vasculopathy: A Clinical and Pathologic Correlation Study

2019 ◽  
Vol 38 (4) ◽  
pp. S58
Author(s):  
D.V. Miller ◽  
M. Revelo ◽  
E. Hammond ◽  
B. Kfoury ◽  
K. Afshar ◽  
...  
Keyword(s):  
Correlation Study ◽  
Cardiac Allograft Vasculopathy ◽  
Cardiac Allograft ◽  
Allograft Vasculopathy ◽  
Pathologic Correlation

scholarly journals Complex fibroadenoma with focal ossification- an enigmatic finding in a less common tumor

2021 ◽  
Vol 8 (5) ◽  
pp. 1650
Author(s):  
Subhransu Kumar Hota ◽  
Ranjana Giri ◽  
Hardik Kabra ◽  
Devika Chauhan ◽  
Prita Pradhan ◽  
...  
Keyword(s):  
Excision Biopsy ◽  
Radiological Findings ◽  
Breast Lump ◽  
In Situ Carcinoma ◽  
Unusual Occurrence ◽  
Malignant Lesions ◽  
Breast Lumps ◽  
Sclerosing Adenosis

Breast lumps have diverse causes including benign as well as malignant lesions. Fibroadenoma (FA) is a common cause of breast lump. Complex fibroadenomas, a particular subtype, pose diagnostic dilemmas due to confusing the radiological findings and hold higher incidence of transformation to malignancy. A 49 year old female presented with a painless lump in right breast for 2 years which appeared calcified on radiology. Excision biopsy was performed which grossly revealed an encapsulated grey-white firm to hard with cystic areas. Microscopically the sections showed a well encapsulated fibroepithelial tumor showing areas of sclerosing adenosis, hyalinization, cysts lined by cuboidal cells with eosinophilic secretions, areas of calcification and ossification. No evidence of lobular hyperplasia or in-situ carcinoma was seen. Patient was advised follow up. This case represents the unusual occurrence of complex fibroadenoma in a middle-aged female showing with ossification.

scholarly journals Correlation study of thyroid nodule cytopathology and histopathology at two institutions in Jordan

CytoJournal ◽  
2018 ◽  
Vol 15 ◽  
pp. 24 ◽  
Author(s):  
Niveen Abdullah ◽  
Manar Hajeer ◽  
Loay Abudalu ◽  
Maher Sughayer
Keyword(s):  
Test Performance ◽  
Predictive Value ◽  
Diagnostic Category ◽  
Needle Aspiration ◽  
Correlation Study ◽  
Follicular Neoplasm ◽  
Risk Of Malignancy ◽  
Thyroid Fna ◽  
Undetermined Significance

Background: Fine-needle aspiration (FNA) plays a fundamental role in determining the appropriate management for patients presenting with thyroid nodules. Aims: The aims of this study are to evaluate thyroid FNA test performance parameters through a cytohistological correlation. Materials and Methods: A retrospective analysis of all thyroid FNAs received over a period of 18 months was carried out. The findings were compared to their subsequent definite diagnoses on surgical specimens as well as to their follow-up repeat FNA results. A total of 499 thyroid FNAs were collected and reviewed against The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). The percentage of each diagnostic category was calculated, and the implied risk of malignancy was determined by comparing the cytology results to their definite diagnoses obtained on the resection specimens. Analytical procedures were performed using Microsoft Excel. Results: Out of 499 thyroid FNAs, a benign interpretation was found in 273 patients (54.7%), atypia of undetermined significance in 81 (16.2%), follicular neoplasm in 20 (4%), suspicious for malignancy in 36 (7.2%), malignant in 32 (6.4%) and were nondiagnostic in 57 patients (11.4%). Only 101 patients (20.2%) underwent surgical resection and 47 (9.4%) underwent a follow-up FNA. After cytohistological correlation, FNA test performance, calculated by excluding the inadequate and undetermined categories revealed test sensitivity, specificity, and diagnostic accuracy of 95.6%, 54.8%, and 78.9%, respectively. The positive predictive value was 75.4%, and the negative predictive value was 89.5%. Conclusions: Our results are comparable to those previously published figures. The rate of atypia of undetermined significance/follicular lesion of undetermined significance is higher than what is currently recommended in TBSRTC.

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