scholarly journals Complex fibroadenoma with focal ossification- an enigmatic finding in a less common tumor

2021 ◽  
Vol 8 (5) ◽  
pp. 1650
Author(s):  
Subhransu Kumar Hota ◽  
Ranjana Giri ◽  
Hardik Kabra ◽  
Devika Chauhan ◽  
Prita Pradhan ◽  
...  
Keyword(s):  
Excision Biopsy ◽  
Radiological Findings ◽  
Breast Lump ◽  
In Situ Carcinoma ◽  
Unusual Occurrence ◽  
Malignant Lesions ◽  
Breast Lumps ◽  
Sclerosing Adenosis

Breast lumps have diverse causes including benign as well as malignant lesions. Fibroadenoma (FA) is a common cause of breast lump. Complex fibroadenomas, a particular subtype, pose diagnostic dilemmas due to confusing the radiological findings and hold higher incidence of transformation to malignancy. A 49 year old female presented with a painless lump in right breast for 2 years which appeared calcified on radiology. Excision biopsy was performed which grossly revealed an encapsulated grey-white firm to hard with cystic areas. Microscopically the sections showed a well encapsulated fibroepithelial tumor showing areas of sclerosing adenosis, hyalinization, cysts lined by cuboidal cells with eosinophilic secretions, areas of calcification and ossification. No evidence of lobular hyperplasia or in-situ carcinoma was seen. Patient was advised follow up. This case represents the unusual occurrence of complex fibroadenoma in a middle-aged female showing with ossification.

scholarly journals Breast MRI in Patients with Unilateral Bloody and Serous-Bloody Nipple Discharge: A Comparison with Galactography

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Lucia Manganaro ◽  
Ilaria D’Ambrosio ◽  
Silvia Gigli ◽  
Francesca Di Pastena ◽  
Guglielmo Giraldi ◽  
...  
Keyword(s):  
Nipple Discharge ◽  
Breast Mri ◽  
Bloody Nipple Discharge ◽  
Ductal Cancer ◽  
Malignant Lesions ◽  
Mass Enhancement ◽  
Higher Sensitivity

Purpose. Assessing the role of breast MRI compared to galactography in patients with unilateral bloody or serous-bloody nipple discharge.Materials and Methods. Retrospective study including 53 unilateral discharge patients who performed galactography and MRI. We evaluated the capability of both techniques in identifying pathology and distinguishing between nonmalignant and malignant lesions. Lesions BIRADS 1/2 underwent follow-up, while the histological examination after surgery has been the gold standard to assess pathology in lesions BIRADS 3/4/5. The ROC analysis was used to test diagnostic MRI and galactography ability.Results. After surgery and follow-up, 8 patients had no disease (15%), 23 papilloma (43%), 11 papillomatosis (21%), 5 ductal cancer in situ (10%), and 6 papillary carcinoma (11%) diagnoses. Both techniques presented 100% specificity; MRI sensitivity was 98% versus 49% of galactography. Considering MRI, we found a statistical association between mass enhancement and papilloma (P<0.001; AUC 0.957; CI 0.888–1.025), ductal enhancement and papillomatosis (P<0.001; AUC 0.790; CI 0.623–0.958), segmental enhancement and ductal cancer in situ (P=0.007; AUC 0.750; CI 0.429–1.071), and linear enhancement and papillary cancer (P=0.011).Conclusions. MRI is a valid tool to detect ductal pathologies in patients with suspicious bloody or serous-bloody discharge showing higher sensitivity and specificity compared to galactography.

hTert, MMP1, Her2 expressions by preneoplastic lesions and breast cancer risk

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10510-10510 ◽  
Author(s):  
J. Hernandez ◽  
M. Mathieu ◽  
E. Taranchon ◽  
M. Spielmann ◽  
S. Delaloge ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Develop Breast Cancer ◽  
Atypical Hyperplasia ◽  
Control Group ◽  
Preneoplastic Lesion ◽  
Preneoplastic Lesions ◽  
In Situ Carcinoma ◽  
Increased Risk

10510 Background: Although it is well established that preneoplastic lesions are associated with an increased risk of breast cancer, there is no available tool to identify which patients will develop breast cancer. Telomerase, matrix metalloprotease 1 (MMP1) and Her2 have all been involved in the early steps of carcinogenesis. In the present study, we have looked at whether the expression of hTert, MMP1 and her2 in preneoplastic lesions were associated with higher risk of breast cancer. Methods: hTert, MMP1 and Her2 expressions by preneoplastic lesions were determined by immunohistochemistry in 34 patients who have subsequently developed a breast cancer (cases), and in 32 patients who did not present breast cancer in the follow-up (control). Patients were matched for age, length of follow-up and type of preneoplastic lesion. The expression of the three biomarkers was compared in the two groups. The initially planned sample size of the study was 90 matched patients, but only 66 samples could be proceed for technical reasons. Results: Median age was 47 and 49 years old in patients with and without further cancer respectively. In the group of patients who subsequently developed breast cancer (cases), preneoplastic lesions consisted in lobular hyperplasia or lobular in situ carcinoma in 17 cases, ductal atypical hyperplasia in 12 cases and mixed lesions in 5 cases. In the control group, preneoplastic lesions consisted in lobular hyperplasia or lobular in situ carcinoma in 18 cases, ductal atypical hyperplasia in 12 cases, mixed lesions in 2 cases. The median interval between the diagnosis of preneoplastic lesion and the occurrence of breast cancer was 72 months (17–291). hTert was expressed in 8 (27%) and 2 (7%) assessable lesions in cases and controls respectively (p = 0.04). MMP1 was expressed in 21 (65%) and 22 (73%) assessable lesions in cases and control respectively (p = 0.49). Her2 was expressed in 6 preneoplastic lesions both in cases and controls (20%). Conclusions: This study suggests that hTert expression by preneoplastic lesions could be associated with an increased risk breast cancer. No significant financial relationships to disclose.

Carcinoma in Situ of the Glottis: Radiotherapy or Excision Biopsy?

1993 ◽  
Vol 102 (8) ◽  
pp. 592-595 ◽  
Author(s):  
George E. Murty ◽  
Joseph P. Diver ◽  
Patrick J. Bradley
Keyword(s):  
Carcinoma In Situ ◽  
Excision Biopsy ◽  
First Year ◽  
Glottic Carcinoma ◽  
First Line ◽  
Laryngeal Function ◽  
Primary Radiotherapy ◽  
Laser Excision

Excision biopsy, radiotherapy, and laryngofissure cordectomy have all been used, but the best treatment regimen for glottic carcinoma in situ remains controversial. A 20-year experience of 37 cases is reported. For the first 10 years biopsy with radiotherapy was the first-line treatment (n = 20), but for the last 10 years surgical or laser excision biopsy alone has been performed (n = 17). The T stage of the carcinoma in situ does not determine its premalignant potential. Malignancy appears to be a recurrence, rather than a new expression of carcinogenesis. Excision biopsy alone provides local control results (75%) comparable to those of primary radiotherapy (85%). Excision biopsy alone, however, retains the option of subsequent radiotherapy with preservation of laryngeal function, but very close follow-up, especially in the first year, is required.

scholarly journals Giant juvenile fibroadenoma: a case report

2018 ◽  
Vol 5 (4) ◽  
pp. 1589
Author(s):  
Prashant Pareek ◽  
Priyanka Pareek
Keyword(s):  
Case Report ◽  
Treatment Plan ◽  
Common Occurrence ◽  
Breast Lump ◽  
Adolescent Population ◽  
Post Operative Period ◽  
Paediatric Patients ◽  
Co Morbidity ◽  
Breast Lumps

Breast Lumps are not a common occurrence in paediatric patients. When encountered, they call for a thorough workup and meticulous treatment plan. Like in adults, fibroadenomas can be seen in children. These are termed 'juvenile fibroadenomas'. When these are larger than 5cm or weigh more than 500gm, they can be called 'giant juvenile fibroadenomas'. These comprise 1-8% of breast lumps in adolescent population. We report here a case of a 10 years old girl who presented with a rapidly growing unilateral breast lump which provided a diagnostic dielemma but was diagnosed as giant juvenile fibroadenoma on histopathology performed post excision. She was successfully treated surgically by removing the entire well-defined lump intact after raising overlying breast flaps. The post-operative period was uneventful. The patient shows no signs of recurrence or co-morbidity even now at follow up OPD visits.

Radiation-Associated Primary Osteosarcoma of the Breast

Pathobiology ◽  
2020 ◽  
Vol 87 (5) ◽  
pp. 322-326
Author(s):  
Helen Bartlett ◽  
Maiar Elghobashy ◽  
Nayneeta Deshmukh ◽  
Rashmi Rao ◽  
Abeer M. Shaaban
Keyword(s):  
Ductal Carcinoma ◽  
Surgical Excision ◽  
Metaplastic Carcinoma ◽  
Post Irradiation ◽  
In Situ Carcinoma ◽  
Complete Surgical Excision ◽  
Spindle Cell Lesion ◽  
Phyllodes Tumour

<b><i>Introduction:</i></b> Non-epithelial primary mammary osteosarcomas are extremely rare. The differentials include metaplastic carcinoma and malignant phyllodes tumour. This is the first published case of primary breast osteosarcoma arising after local radiotherapy. <b><i>Case Presentation:</i></b> A 73-year-old female presented with a right-sided breast lump. The same breast had been irradiated 11 years previously for invasive ductal carcinoma. Diagnostic excision revealed a highly cellular, malignant spindle-cell lesion merged with an osteoid matrix and foci of calcification and bone formation. Immunohistochemistry and molecular studies showed no lines of differentiation. Due to the lack of epithelial/glandular differentiation, in situ carcinoma or leaf-like pattern, the diagnosis of post-irradiation osteosarcoma was made. She underwent mastectomy and is disease-free at 8 months of follow-up. <b><i>Conclusion:</i></b> Post-irradiation osteosarcoma should be considered in the differential diagnosis of breast lesions showing malignant osteoid. Extensive sampling and careful search for epithelial differentiation is required to guide management. Complete surgical excision is recommended.

Retrospective study of a 16 year cohort of BRCA1 and BRCA2 carriers presenting for RRSO: Prevalence of invasive and in-situ carcinoma, with follow-up

2019 ◽  
Vol 153 (2) ◽  
pp. 326-334 ◽  
Author(s):  
F. Blok ◽  
S. Dasgupta ◽  
W.N.M. Dinjens ◽  
E.M. Roes ◽  
H.J. van Beekhuizen ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Brca1 And Brca2 ◽  
In Situ Carcinoma

scholarly journals Breast Diseases in Children and Adolescents - A Two Year Experience in a Private Hospital of Dhaka

2013 ◽  
Vol 2 (1) ◽  
pp. 12-16
Author(s):  
S Islam ◽  
AKMA Morshed ◽  
SA Ali
Keyword(s):  
Children And Adolescents ◽  
Breast Lesion ◽  
Private Hospital ◽  
Breast Diseases ◽  
Secondary Malignancy ◽  
Excision Biopsy ◽  
Age Group ◽  
Fibrocystic Disease ◽  
Breast Lump

Aim and objectives: The aim of this study was to evaluate the spectrum of breast diseases in the children and adolescents in a single hospital and to evaluate the presentation and outcome of these diseases. Methods: This prospective study of childhood and adolescents (2-19years) breast diseases conducted on 47 patients over a period from January 2009 to December 2011. A total of 47 (forty seven) children and adolescents (<19yrs) who complained of a breast lump or pain or nipple symptoms were included for the study. History, clinical examination along with breast ultrasound imaging and cytology and/ or biopsy in some cases was done for diagnosis. Patients were categorized according to their clinical properties and inflammatory, benign and malignant cases were done necessary operations. Other lesions was on medical treatment and under observation and follow-up. Results: The commonest complain was lump followed by pain. Most patients present in the age group 16-19 years (87%). The commonest breast lesion was fibroadenoma(36%). Most of them occur in 16-19 years age group (29.7%). Fibrocystic disease (8.4%) and breast abscess(8.4%) are next 2 common diseases. Diagnostic approach is mostly conservative with ultrasonogram. Few cases need FNAC and excision biopsy. Secondary malignancy may be a possible diagnosis. Awareness is essential for early diagnosis and treatment. DOI: http://dx.doi.org/10.3329/jpsb.v2i1.15157 Journal of Paediatric Surgeons of Bangladesh (2011) Vol. 2 (1): 12-16

scholarly journals Non-mass breast lesions on ultrasound: final outcomes and predictors of malignancy

2017 ◽  
Vol 58 (9) ◽  
pp. 1054-1060 ◽  
Author(s):  
Jong Won Park ◽  
Kyung Hee Ko ◽  
Eun-Kyung Kim ◽  
Cherie M Kuzmiak ◽  
Hae Kyoung Jung
Keyword(s):  
Ductal Carcinoma ◽  
Architectural Distortion ◽  
Breast Lesions ◽  
Invasive Ductal Cancer ◽  
Ultrasound Findings ◽  
Risk Of Malignancy ◽  
Malignant Lesions ◽  
Mass Lesions

Background Breast cancer can present as non-mass lesions (NMLs) on ultrasound. However, knowledge of and understanding about NMLs are scarce. Purpose To retrospectively investigate the final outcomes of sonographic breast NMLs and determine the clinical and radiologic variables associated with malignancy Material and Methods In our radiologic database of breast ultrasound examinations between 2011 and 2014, we found 119 women with 121 NMLs with available histopathologic or sonographic follow-up (over 2 years) data. We collected the clinical variables (patient’s age, symptoms, and mammographic density) and histopathologic data as well as radiologic variables (mammographic and ultrasound findings) after retrospective review by two radiologists, the authors of the current paper, in consensus. We classified the ultrasound findings according to distribution (focal, linear or segmental, and regional) and associated features (calcification, architectural distortion, and ductal changes) and analyzed the associations between variables and malignancy using the t test and χ2 test. Results Of the 121 NMLs, 88 (72.7%) were benign and 33 (27.3%) were malignant. Ductal carcinoma in situ (DCIS) (17/33, 51.5%) and invasive ductal cancer with or without DCIS (13/33, 39.4%) comprised the main malignancies, and malignancy was significantly associated with palpability ( P = 0.000). Mammographic findings and sonographic distribution and associated features were significantly different between benign and malignant lesions ( P = 0.000, P = 0.004, and P = 0.001, respectively). Malignant lesions showed more frequent calcifications combined with asymmetry ( P = 0.000) on mammography and linear-segmental distributions ( P = 0.001) and associated calcifications ( P = 0.019) or architectural distortions ( P = 0.015) on ultrasound. Conclusion Breast NMLs on ultrasound showed high risk of malignancy. Symptoms and mammographic and ultrasound findings can be possible predictors of malignancy in NMLs.

scholarly journals Sweet syndrome induced by radiations during breast cancer treatment

2019 ◽  
Vol 12 (4) ◽  
pp. e223938
Author(s):  
Luc Ollivier ◽  
Emmanuelle Renaud ◽  
Dominique Gouders ◽  
Patrice Plantin
Keyword(s):  
Initial Phase ◽  
Skin Lesions ◽  
Left Breast ◽  
Breast Cancer Treatment ◽  
Low Grade ◽  
Sweet Syndrome ◽  
In Situ Carcinoma ◽  
Grade Malignancy

During the follow-up of a woman treated by radiotherapy for an in situ carcinoma of her left breast, radio-induced skin lesions were diagnosed. They appeared not to be simple radiodermatitis but radio-induced Sweet syndrome. Discussions were led on the benefit of completing the last session of radiotherapy for such a low-grade malignancy while considering the risk of complication from radio-induced disease. General and local corticotherapy rapidly eradicated the fever and asthenia, while the skin lesions disappeared gradually. Moreover, biological improvement was noticed. The presented features of Sweet syndrome are almost similar in their initial phase to the radiodermatitis that is seen in common medical conditions.

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