scholarly journals Systemic Delivery of Modified mRNA Encoding Herpes Simplex Virus 1 Thymidine Kinase for Targeted Cancer Gene Therapy

2013 ◽  
Vol 21 (2) ◽  
pp. 358-367 ◽  
Author(s):  
Yuhua Wang ◽  
Hsing-hao Su ◽  
Yang Yang ◽  
Yunxia Hu ◽  
Lu Zhang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Systemic Delivery ◽  
Herpes Simplex Virus 1 ◽  
Simplex Virus

scholarly journals In vivo enhancement of herpes simplex virus thymidine kinase/ganciclovir cancer gene therapy with polyamine biosynthesis inhibition

2006 ◽  
Vol 118 (11) ◽  
pp. 2907-2910 ◽  
Author(s):  
Tiina Wahlfors ◽  
Tanja Hakkarainen ◽  
Juhani Jänne ◽  
Leena Alhonen ◽  
Jarmo Wahlfors
Keyword(s):  
Gene Therapy ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Polyamine Biosynthesis ◽  
Simplex Virus

Non-Engineered, Naturally Oncolytic Herpes Simplex Virus HSV1 HF-10:Applications for Cancer Gene Therapy

2008 ◽  
Vol 8 (3) ◽  
pp. 208-221 ◽  
Author(s):  
Akihiro Nawa ◽  
ChenHong Luo ◽  
Lumin Zhang ◽  
Yoko Ushjima ◽  
Daisuke Ishida ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Oncolytic Herpes Simplex Virus ◽  
Simplex Virus

scholarly journals Chronic Brain Inflammation and Persistent Herpes Simplex Virus 1 Thymidine Kinase Expression in Survivors of Syngeneic Glioma Treated by Adenovirus-Mediated Gene Therapy: Implications for Clinical Trials

1999 ◽  
Vol 7 (6) ◽  
pp. E13
Author(s):  
William T. Couldwell
Keyword(s):  
Gene Therapy ◽  
Clinical Trials ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Brain Inflammation ◽  
Herpes Simplex Virus 1 ◽  
Glioma Growth ◽  
Simplex Virus

The long-term consequences of adenovirus-mediated conditional cytotoxic gene therapy for gliomas remain uncharacterized. We report here detection of active brain inflammation 3 months after successful inhibition of syngeneic glioma growth. The inflammatory infiltrate consisted of activated macrophages/microglia and astrocytes, and T lymphocytes positive for leucosyalin, CD3 and CD8, and included secondary demyelination. We detected strong widespread herpes simplex virus 1 thymidine kinase immunoreactivity and vector genomes throughout large areas of the brain. Thus, patient evaluation and the design of clinical trials in ongoing and future gene therapy for brain glioblastoma must address not only tumor-killing efficiency, but also long-term active brain inflammation, loss of myelin fibers and persistent transgene expression.

scholarly journals Cancer Gene Therapy Using a Replication-Competent Herpes Simplex Virus Type 1 Vector

1998 ◽  
Vol 228 (3) ◽  
pp. 366-374 ◽  
Author(s):  
Sam S. Yoon ◽  
Nancy M. Carroll ◽  
E. Antonio Chiocca ◽  
Kenneth K. Tanabe
Keyword(s):  
Gene Therapy ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Simplex Virus
Sign in / Sign up

Export Citation Format

Share Document