cancer gene therapy
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2021 ◽  
Author(s):  
Kirill N Kashkin

This study supplements earlier received experimental data using modern databases. Previously tumor-specific activity of several human native and chimeric promoters was demonstrated. Here we compared tumor-specific promoters with promoters of housekeeping genes by the presence of recognition profiles for transcription factors in DNA sequences of the promoters. A number of transcription factor recognition profiles have been identified, the presence of which in promoters may indicate the tumor specificity of the promoters. Transcription factors which may directly regulate promoters of genes involved in cell proliferation and carcinogenesis were revealed by pathway analysis. The results of the study may help in studying the peculiarities of gene transcription in tumors and in the search for or the creation of tumor-specific promoters for cancer gene therapy.


Nano Letters ◽  
2021 ◽  
Author(s):  
Tao Wan ◽  
Qi Pan ◽  
Chongyi Liu ◽  
Jiajing Guo ◽  
Bowen Li ◽  
...  

2021 ◽  
Vol 8 (3) ◽  
pp. 237-238
Author(s):  
Shaikh Mahmood

Breast cancer or carcinoma is mostly characterized by a series of genetic mutations or gene mutations and is therefore ideally place for gene therapy intervention. The aim of gene therapy is to deliver a nucleic acid based drug to either correct or destroy the cells harbouring the genetic aberration. More recently cancer gene therapy has evolved to also encompass delivery of RNA interference technologies, as well as cancer DNA vaccines. However the bottleneck in creating such nucleic acid pharmaceuticals lies in the delivery. Deliverability of DNA is limited as it is circulating nucleases, therefore numerous strategies have been employed to aid with biological transport. This review will discuss some of viral and non viral approaches to breast to breast cancer therapy an present the findings of clinical trials of these therapies in breast cancer patients. Also detailed are some of the most recent developments in non viral approaches to targeting in breast cancer gene therapy. This include transcriptional control, and the development of recombinant, multifunctional bio- inspired system.


2021 ◽  
Vol 4 (9) ◽  
pp. 7168-7175
Author(s):  
Shewaye Lakew Mekuria ◽  
Jin Li ◽  
Cong Song ◽  
Yue Gao ◽  
Zhijun Ouyang ◽  
...  

2021 ◽  
Vol 34 (4) ◽  
Author(s):  
Narges Maleki ◽  
Sarvin MirHakimi ◽  
Sadegh Babashah ◽  
Atefeh Sayadi ◽  
Ghazaleh Parnian ◽  
...  

Author(s):  
Behzad Baradaran ◽  
Ali Mohammadi ◽  
Sara Shamekhi ◽  
Nikoo Majidazar ◽  
Azita Dilmaghani ◽  
...  

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