scholarly journals DNA repair choice defines a common pathway for recruitment of chromatin regulators

2013 ◽  
Vol 4 (1) ◽  
Author(s):  
Gwendolyn Bennett ◽  
Manolis Papamichos-Chronakis ◽  
Craig L. Peterson
2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Gwendolyn Bennett ◽  
Manolis Papamichos‐Chronakis ◽  
Craig Peterson

Cell Cycle ◽  
2020 ◽  
Vol 19 (17) ◽  
pp. 2083-2093
Author(s):  
Veronique A. J. Smits ◽  
Ignacio Alonso-de Vega ◽  
Daniël O. Warmerdam

2015 ◽  
Vol 112 (18) ◽  
pp. E2317-E2326 ◽  
Author(s):  
Claudia Cattoglio ◽  
Elisa T. Zhang ◽  
Ivan Grubisic ◽  
Kunitoshi Chiba ◽  
Yick W. Fong ◽  
...  

The embryonic stem cell (ESC) state is transcriptionally controlled by OCT4, SOX2, and NANOG with cofactors, chromatin regulators, noncoding RNAs, and other effectors of signaling pathways. Uncovering components of these regulatory circuits and their interplay provides the knowledge base to deploy ESCs and induced pluripotent stem cells. We recently identified the DNA-repair complex xeroderma pigmentosum C (XPC)-RAD23B-CETN2 as a stem cell coactivator (SCC) required for OCT4/SOX2 transcriptional activation. Here we investigate the role of SCC genome-wide in murine ESCs by mapping regions bound by RAD23B and analyzing transcriptional profiles of SCC-depleted ESCs. We establish OCT4 and SOX2 as the primary transcription factors recruiting SCC to regulatory regions of pluripotency genes and identify the XPC subunit as essential for interaction with the two proteins. The present study reveals new mechanistic and functional aspects of SCC transcriptional activity, and thus underscores the diversified functions of this regulatory complex.


2005 ◽  
Vol 173 (4S) ◽  
pp. 71-71
Author(s):  
Peter E. Clark ◽  
M. Craig Hall ◽  
Kristin L. Lockett ◽  
Jianfeng Xu ◽  
Sigun L. Zheng ◽  
...  

2006 ◽  
Vol 175 (4S) ◽  
pp. 317-317
Author(s):  
Xifeng Wu ◽  
Jian Gu ◽  
H. Barton Grossman ◽  
Christopher I. Amos ◽  
Carol Etzel ◽  
...  

2005 ◽  
Vol 36 (7) ◽  
pp. 42
Author(s):  
PATRICE WENDLING
Keyword(s):  

1998 ◽  
Vol 3 (1) ◽  
pp. 11-13 ◽  
Author(s):  
Vilhelm A Bohr ◽  
Grigoiy Dianov ◽  
Adayabalam Balajee ◽  
Alfred May ◽  
David K Orren
Keyword(s):  

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