scholarly journals Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer

2013 ◽  
Vol 4 (1) ◽  
Author(s):  
Henrik J. Johansson ◽  
Betzabe C. Sanchez ◽  
Filip Mundt ◽  
Jenny Forshed ◽  
Aniko Kovacs ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Tamoxifen Resistance ◽  
Retinoic Acid Receptor Alpha ◽  
Acid Receptor ◽  
Receptor Alpha

scholarly journals Analysis of gene expression patterns in triple negative breast cancer III: the retinoic acid receptor alpha and other TNBC candidate genes.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Retinoic Acid ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Retinoic Acid Receptor ◽  
Expression Patterns ◽  
Retinoic Acid Receptor Alpha ◽  
Acid Receptor ◽  
Receptor Alpha

Triple negative breast cancer (TNBC) shares overlap with the basal or basal-like molecular subtype of breast cancer and is more frequently diagnosed in women of African descent (black women) for reasons not understood (1, 2). To understand genes whose expression may be of pertinence to the development or progression of triple negative breast cancer, we mined published microarray data (3) comparing global gene expression profiles of TNBC cases, identifying genes whose expression was least different among TNBC cases, indicating conservation of expression patterns suggestive of importance for TNBC biology. We identified the gene encoding the retinoic acid receptor alpha (RARA), a fatty acid elongase (ELOVL1), as well as multiple genes encoding molecules involved in epigenetic functions or with nucleic acid binding or modification properties, including TDRD7, KDM1B, PHF7, TAF5L, as well as the microRNA hsa-miR-605. Kaplan-Meier survival analysis revealed that expression levels of each of these genes correlated with survival outcomes in the basal subtype of human breast cancer, which shares significant overlap with triple negative breast cancer at the level of gene expression (2). RARA, ELOVL1, TDRD7, KDM1B, PHF7, TAF5L and hsa-miR-605 may be of relevance in understanding the etiology or progression of triple negative breast cancer. Together with our previous findings, the data allude to a potential pathogenic mechanism involving transcriptional perturbation of epigenetic machinery in triple negative breast cancer (4, 5).

scholarly journals Trastuzumab treatment in human breast cancer is associated with over-expression of the retinoic acid receptor alpha (RARA).

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Retinoic Acid ◽  
Human Breast Cancer ◽  
Retinoic Acid Receptor ◽  
Human Breast ◽  
Retinoic Acid Receptor Alpha ◽  
Primary Tumors ◽  
Acid Receptor ◽  
Receptor Alpha ◽  
Retinoid Acid

Treatment with trastuzumab has been associated with an increased risk of central nervous system metastasis in patients with human breast cancer (1-5). We performed unbiased transcriptome profiling of primary tumors of patients treated with trastuzumab using published microarray and multiplexed gene expression datasets (6, 7) to understand the transcriptional makeup of breast tumors in the trastuzumab-treated patients. We found that the retinoid acid receptor alpha was among the genes most differentially expressed in the primary tumors of patients treated with trastuzumab; retinoid acid receptor alpha was expressed at significantly higher levels in tumors from patients with trastuzumab as compared to those not treated with trastuzumab. Increased retinoic acid receptor alpha expression is known to confer tamoxifen resistance to human breast cancers (8), and RARA expression is higher in tumors with higher proliferative capacity (9), suggesting that trastuzumab could contribute to resistance to endocrine therapy.

Retinoic Acid Receptor Alpha Amplifications and Retinoic Acid Sensitivity in Breast Cancers

2013 ◽  
Vol 13 (5) ◽  
pp. 401-408 ◽  
Author(s):  
Samar Alsafadi ◽  
Caroline Even ◽  
Coralie Falet ◽  
Aicha Goubar ◽  
Frédéric Commo ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Breast Cancers ◽  
Retinoic Acid Receptor Alpha ◽  
Acid Sensitivity ◽  
Acid Receptor ◽  
Receptor Alpha

Retinoic Acid Receptor Alpha (RARα) Fusion Genes in Leukemia

2017 ◽  
pp. 271-285
Author(s):  
Ganesan Padmavathi ◽  
Javadi Monisha ◽  
Anand Anip ◽  
Krishan Kumar Thakur ◽  
Ajaikumar B. Kunnumakkara
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Fusion Genes ◽  
Retinoic Acid Receptor Alpha ◽  
Acid Receptor ◽  
Receptor Alpha

Inhibitory Effects of Retinoic Acid Receptor Alpha Stimulants on Murine Cataractogenesis through Suppression of Deregulated Calpains

2007 ◽  
Vol 48 (5) ◽  
pp. 2224 ◽  
Author(s):  
Nami Nishikiori ◽  
Makoto Osanai ◽  
Hideki Chiba ◽  
Takashi Kojima ◽  
Hiroshi Ohguro ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Inhibitory Effects ◽  
Retinoic Acid Receptor Alpha ◽  
Acid Receptor ◽  
Receptor Alpha

scholarly journals Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-α)

1990 ◽  
Vol 18 (23) ◽  
pp. 6799-6806 ◽  
Author(s):  
Nigel J. Brand ◽  
Martin Petkovich ◽  
Pierre Chambon
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Retinoic Acid Receptor Alpha ◽  
Acid Receptor ◽  
Receptor Alpha
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