scholarly journals Nitric oxide enhances Th9 cell differentiation and airway inflammation

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Wanda Niedbala ◽  
Anne-Gaelle Besnard ◽  
Daniele Carvalho Nascimento ◽  
Paula Barbim Donate ◽  
Fabiane Sonego ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Differentiation ◽  
Airway Inflammation ◽  
Th9 Cell

scholarly journals BATF3 is sufficient for the induction of Il9 expression and can compensate for BATF during Th9 cell differentiation

2019 ◽  
Vol 51 (11) ◽  
pp. 1-12
Author(s):  
Woo Ho Lee ◽  
Sung Woong Jang ◽  
Hyeong Su Kim ◽  
So Hee Kim ◽  
Jung In Heo ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Transcription Factors ◽  
Cell Differentiation ◽  
Airway Inflammation ◽  
Promoter Activity ◽  
Reporter Assay ◽  
Th9 Cells ◽  
Th9 Cell

AbstractTh9 cells preferentially produce IL-9 and participate in allergic responses and asthma. Differentiation of Th9 cells is induced by IL-4 and TGF-β, and then the cells are amplified by OX40 signals. The transcription factors PU.1, IRF4, and BATF are required for Th9 differentiation. BATF3 is an AP-1 family transcription factor that is highly homologous to BATF; however, its role in Th9 cells is poorly defined. Here, we show that OX40 signaling induced the expression of Batf3 and that its overexpression in the presence or absence of OX40 signaling increased the expression of IL-9 in Th9 cells. BATF3 physically interacted with IRF4 and was bound to the Il9 locus. A transient reporter assay revealed that the BATF3–IRF4 complex induced Il9 promoter activity. BATF3 rescued Il9 expression and restored the capacity to induce the airway inflammation in Batf KO Th9 cells. Thus, BATF3 itself is sufficient for the induction of Th9 cell differentiation and can substitute for BATF during Th9 cell differentiation.

SGK1 enhances Th9 cell differentiation and airway inflammation through NF-κB signaling pathway in asthma

2020 ◽  
Vol 382 (3) ◽  
pp. 563-574
Author(s):  
Xinqi Wu ◽  
Wei Jiang ◽  
Xiaoli Wang ◽  
Chi Zhang ◽  
Jinlong Cai ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Airway Inflammation ◽  
Signaling Pathway ◽  
Th9 Cell

Blimp-1 inhibits Th9 cell differentiation and attenuates diabetic coronary heart disease

2021 ◽  
Vol 95 ◽  
pp. 107510
Author(s):  
Haiyan Chen ◽  
Fangyuan Gao ◽  
Yi Bao ◽  
Jiaoyang Zheng ◽  
Liangliang Sun ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cell Differentiation ◽  
Th9 Cell

Exhaled Nitric Oxide Predicts Eosinophilic Airway Inflammation in COPD

Lung ◽  
2014 ◽  
Vol 192 (4) ◽  
pp. 499-504 ◽  
Author(s):  
Kun-Ta Chou ◽  
Kang-Cheng Su ◽  
Shiang-Fen Huang ◽  
Yi-Han Hsiao ◽  
Ching-Min Tseng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Airway Inflammation ◽  
Exhaled Nitric Oxide

Exhaled nitric oxide estimation by a simple and efficient noninvasive technique and its utility as a marker of airway inflammation in mice

2009 ◽  
Vol 107 (1) ◽  
pp. 295-301 ◽  
Author(s):  
Tanveer Ahmad ◽  
Ulaganathan Mabalirajan ◽  
Duraisamy Arul Joseph ◽  
Lokesh Makhija ◽  
Vijay Pal Singh ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Airway Inflammation ◽  
Airway Remodeling ◽  
Allergen Challenge ◽  
Allergic Airway Inflammation ◽  
Ambient Air ◽  
Exhaled Nitric Oxide ◽  
Noninvasive Technique ◽  
Modified Method ◽  
Chronic Models

Allergic airway inflammation (AI) is commonly associated with enhanced exhaled nitric oxide (ENO) in both humans and mice. Since mouse models are being used to understand various mechanisms of asthma, a noninvasive, simple, and reproducible method to determine ENO in mice is required for serial nonterminal assessment that can be used independent of environmental situations in which the ambient air contains substantial amounts of NO as a contaminant. The aim of this study was to noninvasively measure ENO in individual mice and to test its utility as a marker of AI in different models of allergic AI. We modified the existing ENO measuring methods by incorporating flushing and washout steps that allowed simple but reliable measurements under highly variable ambient NO conditions (1–100 ppb). This method was used to serially follow ENO in acute and chronic models of allergic AI in mice. ENO was reproducibly measured by this modified method and was positively correlated to AI in both acute and chronic models of asthma but was not independently related to airway remodeling. Resolution of AI and other related parameters in dexamethasone-treated mice resulted in reduction of ENO, further confirming this association. Restriction of allergen challenge to pulmonary but not nasal airways was associated with a smaller increase in ENO compared with allergen challenge to both. Hence, ENO can now be reliably measured in mice independent of ambient NO levels and is a valid biomarker for AI. However, nasal and pulmonary airways are likely to be independent sources of ENO, and any results must be interpreted as such.

The effect of omalizumab on small airway inflammation as measured by exhaled nitric oxide in moderate-to-severe asthmatic patients

2014 ◽  
Vol 35 (3) ◽  
pp. 241-249 ◽  
Author(s):  
M. Asghar Pasha ◽  
David Jourd'heuil ◽  
Francis Jourd'heuil ◽  
Lori Mahon ◽  
Francisco Romero ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Airway Inflammation ◽  
Exhaled Nitric Oxide ◽  
Small Airway ◽  
Asthmatic Patients ◽  
Severe Asthmatic
Sign in / Sign up

Export Citation Format

Share Document