The role of site accessibility in microRNA target recognition

2007 ◽  
Vol 39 (10) ◽  
pp. 1278-1284 ◽  
Author(s):  
Michael Kertesz ◽  
Nicola Iovino ◽  
Ulrich Unnerstall ◽  
Ulrike Gaul ◽  
Eran Segal
Keyword(s):  
Target Recognition ◽  
Microrna Target

scholarly journals An alternative mode of microRNA target recognition

2012 ◽  
Vol 19 (3) ◽  
pp. 321-327 ◽  
Author(s):  
Sung Wook Chi ◽  
Gregory J Hannon ◽  
Robert B Darnell
Keyword(s):  
Target Recognition ◽  
Microrna Target ◽  
Alternative Mode

Identification of Mg2+-Binding Sites and the Role of Mg2+on Target Recognition by Calmodulin†

Biochemistry ◽  
1997 ◽  
Vol 36 (14) ◽  
pp. 4309-4316 ◽  
Author(s):  
Shin-ya Ohki ◽  
Mitsuhiko Ikura ◽  
Mingjie Zhang
Keyword(s):  
Binding Sites ◽  
Target Recognition

scholarly journals Conserved Cu-MicroRNAs in Arabidopsis thaliana Function in Copper Economy under Deficiency

Plants ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 141 ◽  
Author(s):  
Muhammad Shahbaz ◽  
Marinus Pilon
Keyword(s):  
Arabidopsis Thaliana ◽  
Small Rnas ◽  
Wild Type ◽  
Microrna Target ◽  
Electron Carrier ◽  
Cu Deficiency ◽  
Regulatory Circuits ◽  
Transgenic Lines ◽  
Cu Homeostasis

Copper (Cu) is a micronutrient for plants. Three small RNAs, which are up-regulated by Cu deficiency and target transcripts for Cu proteins, are among the most conserved microRNAs in plants. It was hypothesized that these Cu-microRNAs help save Cu for the most essential Cu-proteins under deficiency. Testing this hypothesis has been a challenge due to the redundancy of the Cu microRNAs and the properties of the regulatory circuits that control Cu homeostasis. In order to investigate the role of Cu-microRNAs in Cu homeostasis during vegetative growth, we used a tandem target mimicry strategy to simultaneously inhibit the function of three conserved Cu-microRNAs in Arabidopsis thaliana. When compared to wild-type, transgenic lines that express the tandem target mimicry construct showed reduced Cu-microRNA accumulation and increased accumulation of transcripts that encode Cu proteins. As a result, these mimicry lines showed impaired photosynthesis and growth compared to wild type on low Cu, which could be ascribed to a defect in accumulation of plastocyanin, a Cu-containing photosynthetic electron carrier, which is itself not a Cu-microRNA target. These data provide experimental support for a Cu economy model where the Cu-microRNAs together function to allow maturation of essential Cu proteins under impending deficiency.

scholarly journals A structural view of microRNA–target recognition

2016 ◽  
Vol 44 (9) ◽  
pp. e82-e82 ◽  
Author(s):  
Guido Leoni ◽  
Anna Tramontano
Keyword(s):  
Target Recognition ◽  
Microrna Target

scholarly journals Principles of MicroRNA–Target Recognition

PLoS Biology ◽  
2005 ◽  
Vol 3 (3) ◽  
pp. e85 ◽  
Author(s):  
Julius Brennecke ◽  
Alexander Stark ◽  
Robert B Russell ◽  
Stephen M Cohen
Keyword(s):  
Target Recognition ◽  
Microrna Target
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