scholarly journals Rapid host immune response and viral dynamics in herpes simplex virus-2 infection

2013 ◽  
Vol 19 (3) ◽  
pp. 280-288 ◽  
Author(s):  
Joshua T Schiffer ◽  
Lawrence Corey
Keyword(s):  
Immune Response ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Host Immune Response ◽  
Viral Dynamics ◽  
Simplex Virus ◽  
Herpes Simplex Virus 2

scholarly journals Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes

2010 ◽  
Vol 107 (44) ◽  
pp. 18973-18978 ◽  
Author(s):  
J. T. Schiffer ◽  
L. Abu-Raddad ◽  
K. E. Mark ◽  
J. Zhu ◽  
S. Selke ◽  
...  
Keyword(s):  
Immune Response ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Genital Tract ◽  
Host Immune Response ◽  
Simplex Virus ◽  
Herpes Simplex Virus 2

MATHEMATICAL STUDY OF IN-HOST DYNAMICS OF HERPES SIMPLEX VIRUS TYPE 2 TO ASSESS THE IMPACT OF IMMUNE RESPONSE

2017 ◽  
Vol 25 (01) ◽  
pp. 47-70
Author(s):  
CHANDRA N. PODDER ◽  
SYEDA ELHAM SHAHED ◽  
OLUWASEUN SHAROMI ◽  
SAMIR K. BHOWMIK
Keyword(s):  
Immune Response ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Deterministic Model ◽  
Humoral Immune ◽  
Cell Mediated Immune Response ◽  
Simplex Virus ◽  
Herpes Simplex Virus 2 ◽  
The Impact

A new deterministic model for Herpes Simplex Virus-2 (HSV-2) in vivo, which incorporates the cell-mediated and humoral immune responses, is designed and analyzed. The analyses of the model reveal that it has a globally-asymptotically stable (GAS) virus-free equilibrium (VFE) whenever the associated reproduction threshold is less than unity. Also, it has at least one virus-present equilibrium (VPE) when the reproduction threshold exceeds unity (and virus will persist in vivo under this condition). Furthermore, it is shown that a Herpes Simplex Virus-2 (HSV-2) vaccine will be effective in reducing HSV-2 burden in vivo if it reduces the ability of the virus without glycoprotein C (gC) to bind to the host cell or if it reduces the re-activation rate of latent HSV-2. Additionally, the vaccine will also be very effective if it results in an increase in the fraction of the re-activated latent viruses without gC. Numerical simulations of the model show that cell-mediated immune response is more effective (in controlling HSV-2 burden in vivo) than humoral immune response (the latter only offers marginal impact in reducing HSV-2 burden in vivo, except if its effectiveness level is very high). Thus, a future HSV-2 vaccine that boosts cell-mediated immune response is expected to be quite effective in controlling HSV-2 in vivo.

scholarly journals Comparison of the Host Immune Response to Herpes Simplex Virus 1 (HSV-1) and HSV-2 at Two Different Mucosal Sites

2012 ◽  
Vol 86 (13) ◽  
pp. 7454-7458 ◽  
Author(s):  
M. Zheng ◽  
C. D. Conrady ◽  
J. M. Ward ◽  
K. M. Bryant-Hudson ◽  
D. J. J. Carr
Keyword(s):  
Immune Response ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Host Immune Response ◽  
Herpes Simplex Virus 1 ◽  
Simplex Virus ◽  
Hsv 1

scholarly journals Disseminated Herpes Simplex Virus 2 as a Complication of Pregnancy

IDCases ◽  
2021 ◽  
pp. e01107
Author(s):  
Lauren Bougioukas ◽  
Rachel B.C. Psoinos ◽  
David C. Jones ◽  
Erin A. Morris ◽  
Andrew J. Hale
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Simplex Virus ◽  
Herpes Simplex Virus 2

scholarly journals Herpes Simplex Virus 2 ICP0− Mutant Viruses Are Avirulent and Immunogenic: Implications for a Genital Herpes Vaccine

PLoS ONE ◽  
2010 ◽  
Vol 5 (8) ◽  
pp. e12251 ◽  
Author(s):  
William P. Halford ◽  
Ringo Püschel ◽  
Brandon Rakowski
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Genital Herpes ◽  
Simplex Virus ◽  
Herpes Simplex Virus 2

Inactivated Actinobacillus suis in Synergy with Interferon-α Protects Mice against Herpes Simplex Virus-2 Infection

1998 ◽  
Vol 4 (2) ◽  
pp. 76-82
Author(s):  
Takashi Watanabe ◽  
Ikukatsu Suzuki ◽  
Chizuko Hotta ◽  
Teruo Yokokura
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Interferon Α ◽  
Actinobacillus Suis ◽  
Simplex Virus ◽  
Herpes Simplex Virus 2
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