scholarly journals GDNF is not required for catecholaminergic neuron survival in vivo

2015 ◽  
Vol 18 (3) ◽  
pp. 319-322 ◽  
Author(s):  
Jaakko Kopra ◽  
Carolina Vilenius ◽  
Shane Grealish ◽  
Mari-Anne Härma ◽  
Kärt Varendi ◽  
...  
Keyword(s):  
Neuron Survival ◽  
Catecholaminergic Neuron

Reply to “GDNF is not required for catecholaminergic neuron survival in vivo”

2015 ◽  
Vol 18 (3) ◽  
pp. 322-323 ◽  
Author(s):  
Alberto Pascual ◽  
José López-Barneo
Keyword(s):  
Neuron Survival ◽  
Catecholaminergic Neuron

scholarly journals Absolute requirement of GDNF for adult catecholaminergic neuron survival

2008 ◽  
Vol 11 (7) ◽  
pp. 755-761 ◽  
Author(s):  
Alberto Pascual ◽  
María Hidalgo-Figueroa ◽  
José I Piruat ◽  
C Oscar Pintado ◽  
Raquel Gómez-Díaz ◽  
...  
Keyword(s):  
Neuron Survival ◽  
Absolute Requirement ◽  
Catecholaminergic Neuron

scholarly journals The contribution of ciliary neurotrophic factor receptors to adult motor neuron survival in vivo is specific to insult type and distinct from that for embryonic motor neurons

2013 ◽  
Vol 521 (14) ◽  
pp. 3217-3225 ◽  
Author(s):  
Nancy Lee ◽  
Carolyn E. Rydyznski ◽  
Rachel P. Spearry ◽  
Rachel Robitz ◽  
A. John MacLennan
Keyword(s):  
Motor Neuron ◽  
Motor Neurons ◽  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor ◽  
Neuron Survival ◽  
Motor Neuron Survival

Analysis of the neurotrophic effects of GPI-1046 on neuron survival and regeneration in culture and in vivo

Neuroscience ◽  
1999 ◽  
Vol 88 (1) ◽  
pp. 257-267 ◽  
Author(s):  
S Harper ◽  
J Bilsland ◽  
L Young ◽  
L Bristow ◽  
S Boyce ◽  
...  
Keyword(s):  
Neuron Survival

scholarly journals Intravitreous delivery of melatonin affects the retinal neuron survival and visual signal transmission: in vivo and ex vivo study

Drug Delivery ◽  
2020 ◽  
Vol 27 (1) ◽  
pp. 1386-1396
Author(s):  
Ye Tao ◽  
Bang Hu ◽  
Zhao Ma ◽  
Haijun Li ◽  
Enming Du ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Signal Transmission ◽  
Visual Signal ◽  
Retinal Neuron ◽  
Neuron Survival ◽  
Ex Vivo Study

Catecholaminergic neuron survival: getting hooked on GDNF

2008 ◽  
Vol 11 (7) ◽  
pp. 735-736 ◽  
Author(s):  
Carlos F Ibáñez
Keyword(s):  
Neuron Survival ◽  
Catecholaminergic Neuron

scholarly journals Effects of Antioxidant Pretreatment on the Survival of Embryonic Dopaminergic Neurons In Vitro and following Grafting in an Animal Model of Parkinson's Disease

2002 ◽  
Vol 11 (7) ◽  
pp. 653-662 ◽  
Author(s):  
R. M. Love ◽  
R. L. Branton ◽  
J. Karlsson ◽  
P. Brundin ◽  
D. J. Clarke
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Suspensions ◽  
In Vivo Studies ◽  
Control Group ◽  
Neuron Survival ◽  
Graft Tissue ◽  
6 Hydroxydopamine

The effect of pretreating cell suspensions of embryonic rat ventral mesencephala (VM) with antioxidant combinations on the survival of dopaminergic (DA) neurons was studied in vitro and following transplantation into the unilateral 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson's disease. The in vitro experiments examined the effects of two thiol antioxidants, N-acetyl-l-cysteine (NAC) and reduced glutathione (GSH), and a member of the lazaroid family of 21-aminosteroids, U-83836E, singly and in combination, on survival of DA neurons derived from dissociated E14 rat VM tissue. For in vivo studies, cell suspensions were pretreated with combinations of NAC, GSH, and U-83836E prior to transplanting into 6-OHDA-lesioned rats to investigate whether DA neuron survival could be further improved. NAC, GSH, and U-83836E individually increased DA neuron survival in vitro and a combination of all three resulted in the greatest survival. In vivo, pretreatment with U-83836E alone resulted in a significantly greater reduction in amphetamine-induced rotation 6 weeks postgrafting compared with a control group receiving nontreated graft tissue. This functional effect correlated with a significant improvement in DA neuron survival 6 weeks postgrafting. The thiol combination pretreatment of NAC and GSH, and the triple combination of NAC, GSH, and U-83836E, however, failed to improve both functional recovery and DA neuron survival when compared with the nontreated control grafts.

Continuous supply of the neurotrophins BDNF and NT‐3 improve chick motor neuron survival in vivo

2004 ◽  
Vol 23 (4) ◽  
pp. 389-396 ◽  
Author(s):  
Andrew Gibbons ◽  
Nigel Wreford ◽  
Jacinta Pankhurst ◽  
Karen Bailey
Keyword(s):  
Motor Neuron ◽  
Neuron Survival ◽  
Motor Neuron Survival

Fine Structural Changes in the Microvasculature of the Mouse Pinna: Aging and Radiation Injury

1974 ◽  
Vol 32 ◽  
pp. 54-55
Author(s):  
S. Phyllis Steamer ◽  
Rosemarie L. Devine
Keyword(s):  
Structural Changes ◽  
Radiation Treatment ◽  
Arterial Stenosis ◽  
Ultrastructural Changes ◽  
Vascular Effects ◽  
Microvascular Changes ◽  
Surrounding Connective Tissue ◽  
Fission Neutrons ◽  
Total Body

The importance of radiation damage to the skin and its vasculature was recognized by the early radiologists. In more recent studies, vascular effects were shown to involve the endothelium as well as the surrounding connective tissue. Microvascular changes in the mouse pinna were studied in vivo and recorded photographically over a period of 12-18 months. Radiation treatment at 110 days of age was total body exposure to either 240 rad fission neutrons or 855 rad 60Co gamma rays. After in vivo observations in control and irradiated mice, animals were sacrificed for examination of changes in vascular fine structure. Vessels were selected from regions of specific interest that had been identified on photomicrographs. Prominent ultrastructural changes can be attributed to aging as well as to radiation treatment. Of principal concern were determinations of ultrastructural changes associated with venous dilatations, segmental arterial stenosis and tortuosities of both veins and arteries, effects that had been identified on the basis of light microscopic observations. Tortuosities and irregularly dilated vein segments were related to both aging and radiation changes but arterial stenosis was observed only in irradiated animals.

Induction and Differentiation of Dental Epithelium in Vivo and in Vitro

1982 ◽  
Vol 40 ◽  
pp. 142-145
Author(s):  
E. J. Kollar
Keyword(s):  
Connective Tissue ◽  
Oral Mucosa ◽  
Basal Lamina ◽  
Functional Derivatives ◽  
Specific Source ◽  
Dental Epithelium ◽  
Connective Tissue Stroma

The differentiation and maintenance of many specialized epithelial structures are dependent on the underlying connective tissue stroma and on an intact basal lamina. These requirements are especially stringent in the development and maintenance of the skin and oral mucosa. The keratinization patterns of thin or thick cornified layers as well as the appearance of specialized functional derivatives such as hair and teeth can be correlated with the specific source of stroma which supports these differentiated expressions.

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