scholarly journals Craving in Alcohol-Dependent Patients After Detoxification Is Related to Glutamatergic Dysfunction in the Nucleus Accumbens and the Anterior Cingulate Cortex

2013 ◽  
Vol 38 (8) ◽  
pp. 1401-1408 ◽  
Author(s):  
Jochen Bauer ◽  
Anya Pedersen ◽  
Norbert Scherbaum ◽  
Johanna Bening ◽  
Johanna Patschke ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Alcohol Dependent

scholarly journals Comparing the role of the anterior cingulate cortex and 6-hydroxydopamine nucleus accumbens lesions on operant effort-based decision making

2009 ◽  
Vol 29 (8) ◽  
pp. 1678-1691 ◽  
Author(s):  
Mark E. Walton ◽  
James Groves ◽  
Katie A. Jennings ◽  
Paula L. Croxson ◽  
Trevor Sharp ◽  
...  
Keyword(s):  
Decision Making ◽  
Nucleus Accumbens ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
6 Hydroxydopamine

scholarly journals The impacts of actual and perceived nicotine administration on insula functional connectivity with the anterior cingulate cortex and nucleus accumbens

2019 ◽  
Vol 33 (12) ◽  
pp. 1600-1609 ◽  
Author(s):  
Robin N Perry ◽  
Hera E Schlagintweit ◽  
Christine Darredeau ◽  
Carl Helmick ◽  
Aaron J Newman ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Resting State ◽  
Cingulate Cortex ◽  
Anterior Insula ◽  
Anterior Cingulate ◽  
Resting State Functional Connectivity ◽  
Dorsal Anterior Cingulate Cortex ◽  
Nicotine Administration

Background: Changes in resting state functional connectivity between the insula and dorsal anterior cingulate cortex as well as between the insula and nucleus accumbens have been linked to nicotine withdrawal and/or administration. However, because many of nicotine’s effects in humans appear to depend, at least in part, on the belief that nicotine has been administered, the relative contribution of nicotine’s pharmacological actions to such effects requires clarification. Aims: The purpose of this study was to examine the impacts of perceived and actual nicotine administration on neural responses. Methods: Twenty-six smokers were randomly assigned to receive either a nicotine inhaler (4 mg deliverable) or a nicotine-free inhaler across two sessions. Inhaler content instructions (told nicotine vs told nicotine-free) differed across sessions. Resting state functional connectivity between sub-regions of the insula and the dorsal anterior cingulate cortex and nucleus accumbens was measured using magnetic resonance imaging before and after inhaler administration. Results: Both actual and perceived nicotine administration independently altered resting state functional connectivity between the anterior insula and the dorsal anterior cingulate cortex, with actual administration being associated with decreased resting state functional connectivity, and perceived administration with increased resting state functional connectivity. Actual nicotine administration also contralaterally reduced resting state functional connectivity between the anterior insula and nucleus accumbens, while reductions in resting state functional connectivity between the mid-insula and right nucleus accumbens were observed when nicotine was administered unexpectedly. Changes in resting state functional connectivity associated with actual or perceived nicotine administration were unrelated to changes in subjective withdrawal and craving. Changes in withdrawal and craving were however independently associated with resting state functional connectivity between the nucleus accumbens and insula. Conclusions: Our findings highlight the importance of considering non-pharmacological factors when examining drug mechanisms of action.

scholarly journals Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in rats.

2002 ◽  
Vol 116 (4) ◽  
pp. 553-567 ◽  
Author(s):  
Rudolf N. Cardinal ◽  
John A. Parkinson ◽  
Guillaume Lachenal ◽  
Katherine M. Halkerston ◽  
Nung Rudarakanchana ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Central Nucleus ◽  
Nucleus Accumbens Core ◽  
Accumbens Core

scholarly journals Gene Expression Changes in the Prefrontal Cortex, Anterior Cingulate Cortex and Nucleus Accumbens of Mood Disorders Subjects That Committed Suicide

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e35367 ◽  
Author(s):  
Adolfo Sequeira ◽  
Ling Morgan ◽  
David M. Walsh ◽  
Preston M. Cartagena ◽  
Prabhakara Choudary ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Anterior Cingulate Cortex ◽  
Mood Disorders ◽  
Cingulate Cortex ◽  
Anterior Cingulate

scholarly journals Reduced anterior cingulate cortex volume induced by chronic stress correlates with increased behavioral emotionality and decreased synaptic puncta density

2020 ◽  
Author(s):  
Keith A. Misquitta ◽  
Amy Miles ◽  
Thomas D. Prevot ◽  
Jaime K. Knoch ◽  
Corey Fee ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Anterior Cingulate Cortex ◽  
Chronic Stress ◽  
Restraint Stress ◽  
Structural Changes ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
List Type ◽  
Chronic Restraint Stress ◽  
Structural Covariance

AbstractClinical and preclinical studies report that chronic stress induces behavioral deficits as well as volumetric changes and synaptic alterations in corticolimbic brain regions including the anterior cingulate cortex (ACC), amygdala (AMY), nucleus accumbens (NAc) and hippocampus (HPC). In this study, we aimed to investigate the structural changes associated with chronic restraint stress (CRS) exposure and determine the relation between these volumetric changes with behavioral and synaptic alterations. Mice exposed to 2 and 5 weeks of CRS exhibited a significant increase in behavioral emotionality. Macrostructural changes assessed via MRI identified a negative CRS effect on total brain volume, proportional to behavioral emotionality. Region-specific changes within corticolimbic brain structures identified that only the ACC showed significant decrease in volume following CRS exposure (p<0.05). Reduced ACC correlated with increased behavioral emotionality (r=−0.50; p=0.002). Although not significantly altered by CRS, AMY and NAc (but not the HPC) volumes were negatively correlated with behavioral emotionality. Structural covariance network analysis revealed progressive decreased ACC degree following CRS exposure. Finally, reduced ACC volume correlated with decreased PSD95 (but not VGLUT1) puncta density (r=0.35, p<0.05), which also correlated with increased behavioral emotionality (r=−0.36, p<0.05), together suggesting that altered synaptic strength is an underlying substrate of the volumetric and behavioral effects of CRS Our results demonstrate that chronic stress effects on ACC volume and synaptic density are linked to the expression of depressive-like deficits. Our findings highlight key structural and morphological alterations in the ACC relevant to stress-related illness including mood and anxiety disorders.HighlightsChronic restraint stress induces decreases in anterior cingulate volume at 2 and 5 weeks following stress exposureVolume of the anterior cingulate cortex, amygdala and nucleus accumbens negatively correlate with behavioral emotionalityChronic stress induces a progressive decrease in strength and degree in structural covariance network connectivity of the anterior cingulate cortexPuncta density in the anterior cingulate cortex of post-synaptic marker PSD95 negatively correlates with behavioral emotionality and positively correlates with anterior cingulate cortex volume.

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