Glycated hemoglobin A1C and vitamin D and their association with diabetic retinopathy severity

Summary Data from different studies correlating the serum 25(OH)D levels with the metabolic and glycemic parameters in type 2 diabetes patients are still varying. The objective if this study was to describe the correlation between serum 25(OH)D levels and some metabolic parameters in Bulgarian type 2 diabetes patients on oral antidiabetic drugs. One hundred type 2 diabetes patients participated - 56 men and 44 women. The mean age and diabetes duration of the women was 59.0 and 9.8 years, of the men - 58.0 and 7.7 years respectively. Complete patient history was taken and physical examination was performed (body weight and height, waist circumference). Body composition was measured on a leg-to-leg body impedance analyzer (TBF-215, Tanita Corp., Tokyo, Japan). Serum levels of vitamin D were measured by electro-hemi-luminescent detection as 25-(ОН) D Total (ECLIA, Elecsys 2010, Roche Diagnostics, Switzerland). Glycated hemoglobin A1c was measured on a NycoCard reader (Alere™). Total, HDL-cholesterol (direct) and triglycerides were analyzed on a Cobas Integra 400+ analyzer. Correlation analysis was performed on a SPSS 13.0 for Windows platform and included 10 curves. The data were first analyzed for the group as a whole and then separately for men and women as well as in the different vitamin D tertiles. The mean serum 25-OH-vitamin D levels were 23.8 ± 12.1 nmol/l in women and 33.3 ± 20.0 nmol/l in men. We were unable to find any statistically significant correlation between serum 25(OH) vitaminand the serum lipids (cholesterol profile and triglycerides). On the contrary, there was a weak correlation with the glycated hemoglobin A1c (cubic model, R2 = 0.178, p = 0.05) and the BMI (inverse model, R2 = 0.101, p = 0.038). The sub-analyses (men versus women or according to tertiles of vitamin D) did not produce any additional information. The influence of vitamin D on the parameters of the metabolic control in type 2 diabetes is very weak on an individual level. It might be only demonstrated in large epidemiological surveys.

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1411-P: Glycated Hemoglobin A1c Levels during Pregnancy and Risk of Autism in Offspring

Diabetes ◽

10.2337/db19-1411-p ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 1411-P

Author(s):

ANNY XIANG ◽

TING CHOW ◽

MAYRA P. MARTINEZ ◽

DARIOS GETAHUN ◽

KATHLEEN A. PAGE ◽

...

Keyword(s):

Hemoglobin A1c ◽

Glycated Hemoglobin ◽

Glycated Hemoglobin A1c

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Abstract TP208: 1,5-anhydro-d-glucitol as a Predictor of Cerebral Infarction in Patients With Glycated Hemoglobin A1c-based Good Diabetes Control

Stroke ◽

10.1161/str.47.suppl_1.tp208 ◽

2016 ◽

Vol 47 (suppl_1) ◽

Author(s):

Yuji Shiga ◽

Yuhei Kanaya ◽

Shinichi Takeshima ◽

Yasunori Fujikawa ◽

Kazuhiro Takamatsu ◽

...

Keyword(s):

Blood Glucose ◽

Cerebral Infarction ◽

Hba1c Level ◽

Hemoglobin A1c ◽

Glycated Hemoglobin ◽

Glycemic Variability ◽

Diabetes Control ◽

Short Term ◽

High Group ◽

Glycated Hemoglobin A1c

Introduction: Current guidelines set the goal of diabetes control to a glycated hemoglobin A1c (HbA1c) level of <7% in order to prevent macrovascular events. However, we often experience diabetes patients with cerebral infarction (CI), even though their HbA1c level is well-controlled. A reason for this disparity between the diabetes control status and CI onset may be the limitation of HbA1c as a diabetes control indicator. HbA1c reflects the mean blood glucose level over the past 2-3 months. Therefore, with HbA1c, we cannot evaluate short-term blood glucose control and glycemic variability, which are reported as risk factors for CI. Measurement of 1,5-anhydro-D-glucitol (1,5AG) allows the evaluation of these factors. Hypothesis: 1,5AG can be used to evaluate the risk of CI in patients with well-controlled diabetes. Methods: We retrospectively reviewed the medical records of 1169 patients with diabetes who received treatment for CI at our hospital between 2009 and 2014. These patients were divided into the following two groups according to their HbA1c-based diabetes control status: a CI-low group (HbA1c <7%, n=549) and a CI-high group (HbA1c ≧7%, n=620). We also included a non-CI group of 394 diabetes patients without CI (control group), and these patients were further divided into the following two groups in the same manner: a nonCI-low group (n=199) and a nonCI-high group (n=195). The 1,5AG levels were compared between the CI-low and nonCI-low groups, and the CI-high and nonCI-high groups. Results: There was no difference in the 1,5AG level between the CI-high and nonCI-high groups (8.8±7.3% vs. 8.9±7.1%, p=0.83). However, the 1,5AG level was significantly lower in the CI-low group than in the nonCI-low group (12.5±8.1% vs. 15.2±8.8%, p<0.001). This difference remained significant after adjusting for age and sex. Conclusion: The results of this study show that short-term glycemic control and glycemic variability have a significant relationship with existing CI especially in patients with good diabetes control. The 1,5AG level may be a surrogate measure of the risk of CI in patients with HbA1c levels that indicate good diabetes control.

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Glycated Hemoglobin A1c Levels in Type 1 Diabetes Mellitus and Outcomes After Myocardial Infarction

Circulation ◽

10.1161/circulationaha.118.039223 ◽

2019 ◽

Vol 139 (20) ◽

pp. 2380-2382 ◽

Cited By ~ 1

Author(s):

Thomas Nyström ◽

Ulrik Sartipy ◽

Andrea Contardi ◽

Marcus Lind ◽

Rino Bellocco ◽

...

Keyword(s):

Diabetes Mellitus ◽

Myocardial Infarction ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Hemoglobin A1c ◽

Glycated Hemoglobin ◽

Glycated Hemoglobin A1c

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1,5-Anhydroglucitol × glycated hemoglobin A1c/100 as a potential biomarker for islet β-cell function among patients with type 2 diabetes

Acta Diabetologica ◽

10.1007/s00592-019-01452-0 ◽

2019 ◽

Vol 57 (4) ◽

pp. 439-446 ◽

Cited By ~ 2

Author(s):

Hang Su ◽

Xiaojing Ma ◽

Yun Shen ◽

Xingxing He ◽

Lingwen Ying ◽

...

Keyword(s):

Type 2 Diabetes ◽

Hemoglobin A1c ◽

Cell Function ◽

Glycated Hemoglobin ◽

Β Cell ◽

Glycated Hemoglobin A1c ◽

Potential Biomarker ◽

Β Cell Function

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Clinically relevant lot-to-lot reagent difference in a commercial immunoturbidimetric assay for glycated hemoglobin A1c

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2015.07.018 ◽

2015 ◽

Vol 48 (16-17) ◽

pp. 1167-1170 ◽

Cited By ~ 6

Author(s):

Markus A. Thaler ◽

Roman Iakoubov ◽

Andreas Bietenbeck ◽

Peter B. Luppa

Keyword(s):

Hemoglobin A1c ◽

Glycated Hemoglobin ◽

Glycated Hemoglobin A1c

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Measurement of Glycated Hemoglobin A1c from Dried Blood by Turbidimetric Immunoassay

Journal of Diabetes Science and Technology ◽

10.1177/193229680900300527 ◽

2009 ◽

Vol 3 (5) ◽

pp. 1203-1206 ◽

Cited By ~ 23

Author(s):

Ramakrishnan Lakshmy ◽

Ruby Gupta

Keyword(s):

Whole Blood ◽

Large Scale ◽

Hemoglobin A1c ◽

Glycated Hemoglobin ◽

Intraclass Correlation ◽

Dried Blood Spots ◽

Sample Collection ◽

Blood Spots ◽

Glycated Hemoglobin A1c ◽

The Impact

Background: Glycated hemoglobin A1c (A1C) is an important marker in the diagnosis and treatment of diabetes. Dried blood measurement of A1C is useful in large scale epidemiological evaluation of A1C, especially to assess the impact of intervention programs. The possibility of using dried blood for measurement of A1C by the immunoturbidimetric method was explored in the present study. Method: Blood was collected from 30 patients, and blood spots were prepared and dried. The dried blood spot samples were kept for different lengths of time at 4°C to assess stability. Glycated hemoglobin was measured in whole blood and dried blood on the day of collection as well as on days 10 and 15 by immunoturbidimetric method. Results: The A1C values of 30 samples analyzed for comparison between whole blood estimation and dried blood ranged from 4.6% to 9.9%. The mean A1C on the day of sample collection was 6.01% ± 1.58% in fresh whole blood samples and 5.94% ± 1.58 % in dried blood spots. A linear and highly correlated relationship was observed between dried blood A1C values and those in whole blood ( r = 0.986 and intraclass correlation value = 0.993). Glycated hemoglobin values on day 10 and day 15 were comparable with the values on day 1 with a shift in mean of just 1% on day 10 and 3.04% on day 15. Conclusion: In conclusion, dried blood can be used for measurement of A1C by immunoturbidimetric method, and further stability of A1C measurement from dried blood for up to 15 days at 4°C makes it an ideal matrix for transportation in developing countries like India.

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