scholarly journals Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance

Oncogene ◽  
2012 ◽  
Vol 32 (25) ◽  
pp. 3059-3070 ◽  
Author(s):  
V Chell ◽  
K Balmanno ◽  
A S Little ◽  
M Wilson ◽  
S Andrews ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Receptor Tyrosine Kinase ◽  
Kinase Inhibitors ◽  
Fibroblast Growth Factor Receptor ◽  
Acquired Resistance ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Cell Responses ◽  
Receptor Tyrosine Kinase Inhibitors

FGFR3 targeting strategies for achondroplasia

2012 ◽  
Vol 14 ◽  
Author(s):  
Melanie B. Laederich ◽  
William A. Horton
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Receptor Tyrosine Kinase ◽  
Kinase Inhibitors ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Therapeutic Strategies ◽  
Signalling Pathways ◽  
Fibroblast Growth ◽  
Blocking Antibodies

Mutations that exaggerate signalling of the receptor tyrosine kinase fibroblast growth factor receptor 3 (FGFR3) give rise to achondroplasia, the most common form of dwarfism in humans. Here we review the clinical features, genetic aspects and molecular pathogenesis of achondroplasia and examine several therapeutic strategies designed to target the mutant receptor or its signalling pathways, including the use of kinase inhibitors, blocking antibodies, physiologic antagonists, RNAi and chaperone inhibitors. We conclude by discussing the challenges of treating growth plate disorders in children.

scholarly journals Aryl extensions of thienopyrimidinones as fibroblast growth factor receptor 1 kinase inhibitors

2011 ◽  
Vol 52 (17) ◽  
pp. 2228-2231 ◽  
Author(s):  
Anil R. Ekkati ◽  
Valsan Mandiyan ◽  
Krishna P. Ravindranathan ◽  
Jae H. Bae ◽  
Joseph Schlessinger ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Kinase Inhibitors ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth

scholarly journals Akt Activation Mediates Acquired Resistance to Fibroblast Growth Factor Receptor Inhibitor BGJ398

2017 ◽  
Vol 16 (4) ◽  
pp. 614-624 ◽  
Author(s):  
Jharna Datta ◽  
Senthilkumar Damodaran ◽  
Hannah Parks ◽  
Cristina Ocrainiciuc ◽  
Jharna Miya ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Acquired Resistance ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Akt Activation ◽  
Receptor Inhibitor
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