Abstract 3448: Fibroblast growth factor receptor is expressed as a constitutively active receptor tyrosine kinase in chronic lymphocytic leukemia B cells and exists in an active complex with Axl: Dual targeting in CLL

2014 ◽  
Author(s):  
Sutapa Sinha ◽  
Justin Boyson ◽  
Charla Secreto ◽  
Steven L. Warner ◽  
Neil E. Kay ◽  
...  
Keyword(s):  
Growth Factor ◽  
Chronic Lymphocytic Leukemia ◽  
Fibroblast Growth Factor ◽  
Receptor Tyrosine Kinase ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Lymphocytic Leukemia ◽  
Fibroblast Growth ◽  
Active Complex ◽  
Dual Targeting

Novel inhibitor for fibroblast growth factor receptor tyrosine kinase

2007 ◽  
Vol 17 (17) ◽  
pp. 4812-4818 ◽  
Author(s):  
Naparat Kammasud ◽  
Chantana Boonyarat ◽  
Satoshi Tsunoda ◽  
Hiroaki Sakurai ◽  
Ikuo Saiki ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tyrosine Kinase ◽  
Fibroblast Growth Factor ◽  
Receptor Tyrosine Kinase ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth

FGFR3 targeting strategies for achondroplasia

2012 ◽  
Vol 14 ◽  
Author(s):  
Melanie B. Laederich ◽  
William A. Horton
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Receptor Tyrosine Kinase ◽  
Kinase Inhibitors ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Therapeutic Strategies ◽  
Signalling Pathways ◽  
Fibroblast Growth ◽  
Blocking Antibodies

Mutations that exaggerate signalling of the receptor tyrosine kinase fibroblast growth factor receptor 3 (FGFR3) give rise to achondroplasia, the most common form of dwarfism in humans. Here we review the clinical features, genetic aspects and molecular pathogenesis of achondroplasia and examine several therapeutic strategies designed to target the mutant receptor or its signalling pathways, including the use of kinase inhibitors, blocking antibodies, physiologic antagonists, RNAi and chaperone inhibitors. We conclude by discussing the challenges of treating growth plate disorders in children.

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