scholarly journals Mammillary body injury in neonatal encephalopathy: a multicentre, retrospective study

2021 ◽  
Author(s):  
Maarten. H. Lequin ◽  
Sylke. J. Steggerda ◽  
Mariasavina Severino ◽  
Domenico Tortora ◽  
Alessandro Parodi ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Neonatal Intensive Care ◽  
List Type ◽  
Neonatal Encephalopathy ◽  
Memory Impairments ◽  
Hypothermia Treatment ◽  
Ischaemic Brain ◽  
The Brain ◽  
Multicentre Retrospective Study

Abstract Background The mammillary bodies (MBs) have repeatedly been shown to be critical for memory, yet little is known about their involvement in numerous neurological conditions linked to memory impairments, including neonatal encephalopathy. Methods We implemented a multicentre retrospective study, assessing magnetic resonance scans of 219 infants with neonatal encephalopathy who had undergone hypothermia treatment in neonatal intensive care units located in the Netherlands and Italy. Results Abnormal MB signal was observed in ~40% of infants scanned; in half of these cases, the brain appeared otherwise normal. MB involvement was not related to the severity of encephalopathy or the pattern/severity of hypoxic–ischaemic brain injury. Follow-up scans were available for 18 cases with abnormal MB signal; in eight of these cases, the MBs appeared severely atrophic. Conclusions This study highlights the importance of assessing the status of the MBs in neonatal encephalopathy; this may require changes to scanning protocols to ensure that the slices are sufficiently thin to capture the MBs. Furthermore, long-term follow-up of infants with abnormal MB signal is needed to determine the effects on cognition, which may enable the use of early intervention strategies. Further research is needed to assess the role of therapeutic hypothermia in MB involvement in neonatal encephalopathy. Impact The MBs are particularly sensitive to hypoxia in neonates. Current hypothermia treatment provides incomplete protection against MB injury. MB involvement is likely overlooked as it can often occur when the rest of the brain appears normal. Given the importance of the MBs for memory, it is necessary that this region is properly assessed in neonatal encephalopathy. This may require improvements in scanning protocols.

Adherence to follow‐up recommendations for dogs with apocrine gland anal sac adenocarcinoma: A multicentre retrospective study

2020 ◽  
Vol 18 (4) ◽  
pp. 683-688
Author(s):  
Aidan R. Chambers ◽  
Owen T. Skinner ◽  
Megan A. Mickelson ◽  
Ariel N. Schlag ◽  
James Ryan Butler ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Apocrine Gland ◽  
Anal Sac ◽  
Multicentre Retrospective Study

Ocular dermoids in 13 cats: a multicentre retrospective study

2021 ◽  
pp. 1098612X2110438
Author(s):  
Anaïs Cathelin ◽  
Anne-Sandrine Augsburger ◽  
Jennifer Anne ◽  
Sylvain Medan ◽  
Julien Michel ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Ocular Surface ◽  
Rare Condition ◽  
Surgical Excision ◽  
Genetic Transmission ◽  
Study Population ◽  
The Mean ◽  
Lost To Follow Up ◽  
Multicentre Retrospective Study

Objectives The aim of this multicentre retrospective study was to review the clinical data, outcomes and histopathological features of cats that had been treated for ocular surface dermoids. Methods Thirteen cats from various private practices in France with a clinical diagnosis of ocular surface dermoid were included in the study. Results The mean age of the study population at the time of diagnosis was 5 months. There were nine males and four females. Three different breeds were, including: domestic shorthair (n = 7), Birman (n = 4) and Havana Brown (n = 2). Two of the four Birmans were related (same sire). The two Havana Browns were also related (same sire). All of the dermoids were unilateral. Five of the dermoids were strictly conjunctival. Four affected both the conjunctiva and the cornea. Three affected both the conjunctiva and the eyelid, and one was strictly corneal. They were located in various positions: temporal (n = 9), inferonasal (n = 1), dorsonasal (n = 1) and dorsotemporal (n = 1). The last dermoid was heterogeneous and involved the nasal, dorsal and temporal quadrants. Concurrent eye diseases were observed in five patients: four cats exhibited associated eyelid agenesis and one cat exhibited persistent iris-to-iris pupillary membranes. Ten dermoids were surgically excised with no recurrences. Surgery was not performed for three cats: one cat died a few days after diagnosis and two cats were lost to follow-up after initial presentation. Conclusions and relevance Ocular surface dermoids are a rare condition in cats that can be treated successfully by surgical excision. Although our study reports only a small number of cases, the observation of ocular surface dermoids in two related cats in two different breeds indicates that genetic transmission is likely.

scholarly journals Treatment and follow-up of venous thrombosis in the neonatal intensive care unit: a retrospective study

2016 ◽  
Vol 37 (3) ◽  
pp. 306-310 ◽  
Author(s):  
J C Bohnhoff ◽  
S A DiSilvio ◽  
R K Aneja ◽  
J R Shenk ◽  
Y A Domnina ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Retrospective Study ◽  
Neonatal Intensive Care Unit ◽  
Venous Thrombosis ◽  
Neonatal Intensive Care

When dreams become nightmares: Post traumatic stress disorder symptoms in mothers of NICU babies

2011 ◽  
Vol 26 (S2) ◽  
pp. 1097-1097
Author(s):  
Y. Greenberg ◽  
N. Naor ◽  
P. Sirota ◽  
L. Sirota
Keyword(s):  
Neonatal Intensive Care ◽  
Stress Disorder ◽  
Full Term ◽  
List Type ◽  
Post Traumatic Stress ◽  
Preterm Babies ◽  
Post Traumatic ◽  
Severity Of Depression ◽  
Maternal Responses

IntroductionHaving a critically ill baby in the NICU is very difficult to cope with, and mothers may feel a whole host of emotions as they cope with the loss of the last part of pregnancy, the dream of a healthy birth, the loss of the first weeks or months of their baby's life. This distress may resemble posttraumatic stress disorder (PTSD).ObjectiveTo examine mothers’ responses to having a baby (preterm or full term) in neonatal intensive -care unit and to determine if they fulfill the criteria for PTSD or depression.MethodsForty nine mothers of pre term babies and ten mothers of full term babies who had been hospitalized in NICU of Schneider Children's Hospital, Israel, were interviewed at the follow up clinic between 4–17 months after birth. The evaluation was carried out by one senior psychiatrist and was based on diagnostic criteria for PTSD and depression according to DSM-4. Severity of PTSD was measured by PSS-sr and the severity of depression by HAMD-Distress factors in NICU setting were evaluated by Parental Stressor Scale (M&F&C Scale).Results1.50% of mothers of preterm babies and 40% of mothers of full term babies fulfill the criteria for PTSD (N.S.).2.25% (15/59) of the whole sample had moderate to severe PTSD.3.A strong correlation between PTSD and severity of stress during hospitalization in NICU was found.ConclusionThe development of later ptsd and depression can be predicted by maternal responses to hospitalization of her baby in nicu.

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