The effects of sodium bicarbonate infusion on cerebrovascular function in newborn pigs

2021 ◽  
Author(s):  
Sandeep K. Chilakala ◽  
Helena Parfenova ◽  
Massroor Pourcyrous
Keyword(s):  
Sodium Bicarbonate ◽  
Cerebrovascular Function ◽  
Newborn Pigs ◽  
Bicarbonate Infusion ◽  
Sodium Bicarbonate Infusion

scholarly journals Patterns in the Parathyroid Response to Sodium Bicarbonate Infusion Test in Healthy Volunteers

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Theodossis S. Papavramidis ◽  
Olympia E. Anastasiou ◽  
Ioannis Pliakos ◽  
Nick Michalopoulos ◽  
Mike Polyzonis ◽  
...  
Keyword(s):  
Vitamin D ◽  
Sodium Bicarbonate ◽  
Healthy Volunteers ◽  
Infusion Test ◽  
Normal Individuals ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Low Levels ◽  
Bicarbonate Infusion ◽  
Sodium Bicarbonate Infusion

Background. The sodium bicarbonate infusion test evaluates the function of the parathyroid glands. The present study aims to evaluate the range of parathyroid response in healthy individuals and the potential influence of various factors.Methods. Fifty healthy volunteers were subjected to the test. Levels of vitamin D, calcium, albumin, and PTH were measured before infusion. PTH was measured at 3, 5, 10, 30, and 60 minutes after infusion.Results. A curve describing the response of parathyroids to the test was drawn. Twenty percent of the subjects had blunted PTH response. No significant difference was observed between normal and blunted responders concerning age, BMI, baseline PTH, or calcium levels. Nonetheless, there was a significant difference in vitamin D levels (P=0.024).Interpretation. The test is easy to perform and may be used for everyday screening. It has to be clarified whether our observations are, at least partly, produced due to the presence of individuals with a constitutively blunted response or if low levels of vitamin D decrease the ability of the parathyroids to respond. Whichever the case, PTH response of normal individuals to sodium bicarbonate infusion test is more varied than previously thought and vitamin D levels influence it.

Extracorporeal bicarbonate space after bicarbonate or a bicarbonate-carbonate mixture in acidotic dogs

1989 ◽  
Vol 67 (6) ◽  
pp. 2331-2334 ◽  
Author(s):  
N. B. Kindig ◽  
D. S. Sherrill ◽  
J. I. Shapiro ◽  
G. F. Filley
Keyword(s):  
Animal Model ◽  
Sodium Bicarbonate ◽  
Volume Of Distribution ◽  
Serum Bicarbonate ◽  
Bicarbonate Infusion ◽  
Co2 Excretion ◽  
Sodium Bicarbonate Infusion

The effects of sodium bicarbonate and a bicarbonate-carbonate mixture on expired CO2 and the volume of distribution of bicarbonate were studied in eight anesthetized, paralyzed, and ventilated dogs made acidotic with HCl (5 mmol/kg) infused over 90 min. Both sodium bicarbonate and Carbicarb resulted in systemic alkalinization and comparable increases in the serum bicarbonate at 50 min (7.07 +/- 0.91 vs. 7.99 +/- 0.77, respectively; P = NS). Sodium bicarbonate infusion resulted in an increase in CO2 excretion that accounted for a fractional CO2 excretion of 0.20 +/- 0.09, whereas infusion of a bicarbonate-carbonate mixture resulted in a fractional CO2 excretion of -0.06 +/- 0.09 (P less than 0.01). The uncorrected volume of distribution of bicarbonate after sodium bicarbonate infusion was higher than that seen with the bicarbonate-carbonate mixture (0.60 +/- 0.07 vs. 0.34 +/- 0.03 l/kg; P less than 0.01). However, when the volume of bicarbonate distribution was corrected for expired CO2, there was no difference between treatment with sodium bicarbonate and the bicarbonate-carbonate mixture (0.44 +/- 0.07 vs. 0.38 +/- 0.04 l/kg; P = NS). These data demonstrate that, in this animal model of acidosis, sodium bicarbonate treatment of systemic acidosis is accompanied by a generation of a considerable amount of CO2, whereas treatment with a bicarbonate-carbonate mixture is not. This suggests that in states of impaired ventilation, a bicarbonate-carbonate mixture may offer more efficient systemic alkalinization and may be associated with less CO2 generation than sodium bicarbonate.

scholarly journals Crack Cocaine-Induced Cardiac Conduction Abnormalities Are Reversed by Sodium Bicarbonate Infusion

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Carlos Henrique Miranda ◽  
Antônio Pazin-Filho
Keyword(s):  
Cardiac Arrest ◽  
Sodium Bicarbonate ◽  
Crack Cocaine ◽  
Tricyclic Antidepressant ◽  
Cardiac Conduction ◽  
Clinical Complications ◽  
Bicarbonate Infusion ◽  
Electrocardiographic Abnormalities ◽  
Intravenous Sodium ◽  
Sodium Bicarbonate Infusion

We report a dramatic case of a 19-year-old man with crack cocaine overdose with important clinical complications as cardiac arrest due to ventricular fibrillation andepileptics status. During this intoxication, electrocardiographic abnormalities similar to those found in tricyclic antidepressant poisoning were observed, and they were reversed by intravenous sodium bicarbonate infusion.

The effects of intravenous theophylline infusion versus intravenous Sodium Bicarbonate infusion on Lithium clearance in normal subjects

1988 ◽  
Vol 25 (2) ◽  
pp. 203-211 ◽  
Author(s):  
Sheldon G. Holstad ◽  
Paul J. Perry ◽  
Roger G. Kathol ◽  
Richard W. Carson ◽  
Stephen J. Krummel
Keyword(s):  
Sodium Bicarbonate ◽  
Normal Subjects ◽  
Lithium Clearance ◽  
Bicarbonate Infusion ◽  
Intravenous Sodium ◽  
Sodium Bicarbonate Infusion

Distal acidification in the rabbit: role of diet and blood pH

1982 ◽  
Vol 243 (4) ◽  
pp. F364-F371
Author(s):  
M. Cruz-Soto ◽  
D. Batlle ◽  
S. Sabatini ◽  
J. A. Arruda ◽  
N. A. Kurtzman
Keyword(s):  
Sodium Bicarbonate ◽  
Ammonium Chloride ◽  
Sodium Phosphate ◽  
Blood Ph ◽  
Normal Urine ◽  
Collecting Tubules ◽  
Bicarbonate Infusion ◽  
Neutral Sodium ◽  
Sodium Bicarbonate Infusion

A distal acidification defect is said to exist in rabbits because this species does not achieve a normal urine minus blood (U-B) PCO2 gradient in response to sodium bicarbonate infusion. This observation contrasts with data derived from studies in isolated rabbit cortical collecting tubules that have shown an acidifying capacity when the tubules were obtained from acidotic animals. The present study was designed to examine the role of diet and blood pH on distal acidification in the rabbit. Maximal alkalinization of the urine by acute sodium bicarbonate infusion was associated with a low U-B PCO2 gradient (0.7 +/- 2.1 mmHg). Rabbits made acidotic by ammonium chloride administration for 1 wk achieved a substantial U-B PCO2 gradient (29 +/- 5 mmHg) in response to neutral sodium phosphate infusion. To further evaluate the role of blood pH on the ability to raise U-B PCO2 gradient, rabbits and rats made acidotic by chronic ammonium chloride administration were studied. Neutral sodium phosphate was then infused to stimulate distal acidification. At comparable levels of urinary phosphate concentration and blood pH, acidotic rabbits were able to achieve a U-B PCO2 (50 +/- 7 mmHg) comparable with that of acidotic rats (48 +/- 8.3 mmHg). These data show that the failure of rabbits to raise U-B PCO2 gradient can be partially corrected by prior exposure to acid in the diet and further corrected by maintaining the blood pH within the acidotic range.

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