scholarly journals Geriatric assessment and quality of life in older patients considered for allogeneic hematopoietic cell transplantation: a prospective risk factor and serial assessment analysis

2018 ◽  
Vol 53 (5) ◽  
pp. 565-575 ◽  
Author(s):  
Barbara Deschler ◽  
Gabriele Ihorst ◽  
Susanne Schnitzler ◽  
Hartmut Bertz ◽  
Juergen Finke
Keyword(s):  
Quality Of Life ◽  
Risk Factor ◽  
Cell Transplantation ◽  
Geriatric Assessment ◽  
Older Patients ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Allogeneic Hematopoietic Cell Transplantation ◽  
Prospective Risk

scholarly journals Quality of life after allogeneic hematopoietic cell transplantation

Blood ◽  
2009 ◽  
Vol 114 (1) ◽  
pp. 7-19 ◽  
Author(s):  
Joseph Pidala ◽  
Claudio Anasetti ◽  
Heather Jim
Keyword(s):  
Quality Of Life ◽  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Standard Dose ◽  
Hematopoietic Cell ◽  
Allogeneic Hematopoietic Cell Transplantation ◽  
Effective Control ◽  
High Dose ◽  
Allogeneic Hct

Abstract High-dose therapy with allogeneic hematopoietic cell transplantation (HCT) offers effective control and potential cure of hematopoietic malignancies, but with the cost of associated morbidity that includes adverse effects on quality of life (QOL). A growing body of literature has characterized this impact. Longitudinal studies suggest early moderate impairments that largely return to pretransplantation levels by day 100; the majority of studies suggest that greater than 60% of patients report good to excellent QOL in years 1 to 4 after HCT. Comparisons of allogeneic HCT with autologous HCT and standard-dose chemotherapy suggest impairments in QOL and a different trajectory of recovery in allogeneic HCT, but these conclusions are limited by confounding variables. Cross-sectional studies suggest larger and more persistent decrements in QOL in comparison with matched noncancer controls and population normative data. Acute and chronic graft-versus-host disease (GVHD) are significant threats to QOL. Behavioral interventions show promise to maintain or improve quality of life after allogeneic HCT. The review concludes with recommendations to investigators and clinicians as the state of this research advances.

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