Mapping of truncated O-glycans in cancers of epithelial and non-epithelial origin

Author(s):  
Troels Boldt Rømer ◽  
Mikkel Koed Møller Aasted ◽  
Sally Dabelsteen ◽  
Aaron Groen ◽  
Julia Schnabel ◽  
...  
Keyword(s):  
Author(s):  
Raoul Fresco ◽  
Mary Chang-Lo

Confusion surrounds the nature of the “adenomatoid tumor” of the testis, as evidenced by the large number of synonyms which have been ascribed to it. Various authors have considered the tumor to be of endothelial, mesothelial or epithelial origin. There appears to be no controversy as to the stromal elements of the tumor, which consists mainly of smooth muscle and fibrous tissue. It is the irregular gland-like spaces which have given rise to the numerous theories as to its histogenesis, and even recent ultrastructural studies fail to agree on the origin of these structures.Electron microscopy of a typical intrascrotal adenomatoid tumor showed the gland-like spaces to be lined by epithelial cells (Fig. 1), rich in cytoplasmic tonofibrils and united to each other by numerous desmosomes (Fig. 2). The most salient feature of these epithelial cells was the presence on their luminal surface of numerous long and repeatedly branching microvillous structures of the type known as stereocilia (Fig. 3). These are extremely long slender cell processes which are as much as three to four times the length of those in brush borders.


Author(s):  
A.N. Bochkareva ◽  
◽  
V.V. Egorov ◽  
G.P. Smoliakova ◽  
P.A. Banshchikov ◽  
...  

1970 ◽  
Vol 2 (1) ◽  
pp. 33-45 ◽  
Author(s):  
Bettina H. Harrison ◽  
Conald I. Patt ◽  
John T. Albright

1990 ◽  
Vol 1 (2) ◽  
pp. 137 ◽  
Author(s):  
Y. Miyagoe ◽  
J. Nakayama ◽  
D. Xu ◽  
T. Miyaoka ◽  
Y. Hori
Keyword(s):  
Nk Cell ◽  

2021 ◽  
Vol 7 (4) ◽  
pp. 302-305
Author(s):  
Sruthi Chandra V ◽  
V Ramesh ◽  
P D Balamurali ◽  
Nirima Oza

Ameloblastoma is a benign neoplasm of odontogenic epithelial origin which comprises of several clinical, radiological and histological varieties. Among these, unicystic variant is the least explored and its mural subtype shows a high aggressiveness and risk of recurrence and comparable with that of conventional ameloblastoma. Herein, we present a case of mural ameloblastoma of maxilla in a 32-year old female.


2005 ◽  
Vol 48 (spe2) ◽  
pp. 29-35 ◽  
Author(s):  
Carla Roberta Dias ◽  
Barbara Marczewski ◽  
Vanessa Moraes ◽  
Marycel Figols de Barboza ◽  
João Alberto Osso Junior

Monoclonal antibodies (Mabs) have been useful for immunoscintigraphic applications in clinical diagnosis since they were introduced in the practice of nuclear medicine. The ior egf/r3 (Centis, Cuba) is a murine monoclonal antibody against epidermal growth factor receptor (EGF-R) and has been widely used in the radioimmunodiagnosis of tumors of epithelial origin. Labeled with 99mTc, its main application in Nuclear Medicine is the follow up, detection and evaluation of tumor recurrences. The objective of this work is to describe the preparation of a lyophilized formulation (kit) for radiolabeling the Mab ior egf/r3 with 99mTc for immunoscintigraphic applications. Radiolabeling efficiency, effects on immunoreactivity, image studies and stability of the formulation are reported. The study demonstrated that the kit formulation can be labeled with 99mTc at high yields and can be used to visualize in vivo human tumors of epithelial origin by immunoscintigraphy studies.


2017 ◽  
Vol 1 (S1) ◽  
pp. 57-57
Author(s):  
Jennifer Knudtson ◽  
Ya-Guang Liu ◽  
Marlen Tellez Santos ◽  
Rajeshwar Tekmal ◽  
Ratna Vadlamudi ◽  
...  

OBJECTIVES/SPECIFIC AIMS: To further elucidate the role of estrogen receptor β (ER-β) in the early endometriotic lesion attachment. METHODS/STUDY POPULATION: EECs were immortalized using a telomerase vector. Immortalized cells and parental cells were characterized by genotyping, and expression of ER-β as well as other epithelial cell markers. ER-β was knocked-down in immortalized EECs using lentivirus-mediated shRNA transduction. ER-β knockdown was confirmed by RT-qPCR and Western analysis. EEC cells with or without ER-β knockdown were used to assess their attachment to PMCs in an established in vitro assay (Lucidi, 2005). Results were analyzed with Student t-test. RESULTS/ANTICIPATED RESULTS: Genotyping using karyotype assay confirmed a normal chromosomal profile. Also positive staining for cytokeratin and lack of any staining with vimentin confirms the epithelial origin of these cells. ER-β knockdown has a significant decrease in attachment compared to control (p=0.02). DISCUSSION/SIGNIFICANCE OF IMPACT: Primary and immortalized cells were 46XX, cytokeratin positive, and vimentin negative confirming their epithelial origin. ER-β knockdown has a significant decrease in attachment compared with control.


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