scholarly journals STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion

2019 ◽  
Vol 26 (11) ◽  
pp. 2314-2328 ◽  
Author(s):  
Chuan-xia Zhang ◽  
Shu-biao Ye ◽  
Jian-jiao Ni ◽  
Ting-ting Cai ◽  
Yi-na Liu ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cell Expansion ◽  
Suppressor Cell ◽  
Myeloid Derived Suppressor Cell

Metabolic changes and interaction of tumor cell, myeloid-derived suppressor cell and T cell in hypoxic microenvironment

2020 ◽  
Author(s):  
Xiantu Ou ◽  
Weibiao Lv
Keyword(s):  
Tumor Microenvironment ◽  
Regulatory Protein ◽  
Tumor Hypoxia ◽  
Suppressor Cells ◽  
Suppressor Cell ◽  
Inflammatory Factors ◽  
Tumor Escape ◽  
Myeloid Derived Suppressor Cells ◽  
Myeloid Derived Suppressor Cell ◽  
Transcriptional Regulatory

It is universally acknowledged that a large number of immune cells, as well as inflammatory factors, regulatory factors and metabolites, accumulate in the tumor microenvironment to jointly promote tumor escape, development and metastasis. Hypoxia is one of the characteristics in tumor microenvironment and is a common phenomenon in all solid tumors. In tumor hypoxia response, there is a key regulator called HIF-1a, which is a key transcriptional regulatory protein that regulates many critical genes. In this paper, the effects of hypoxia on glucose metabolism of tumor cells, myeloid-derived suppressor cells and T cells in tumor microenvironment were reviewed, and the interaction among the three was also described.

ARGX-111 shows activity in MET-amplified patients in a phase-I study and in preclinical models of myeloid-derived suppressor cell (MDSC) depletion in the tumor microenvironment.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e14016-e14016 ◽  
Author(s):  
Christian Diego Rolfo ◽  
Philippe Georges Aftimos ◽  
Jean-Rene Pallandre ◽  
Virginia Morello ◽  
Adeline Bouard ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Phase I ◽  
Phase I Study ◽  
Suppressor Cell ◽  
Preclinical Models ◽  
Myeloid Derived Suppressor Cell

scholarly journals Exosomal miRNA-107 induces myeloid-derived suppressor cell expansion in gastric cancer

2019 ◽  
Vol Volume 11 ◽  
pp. 4023-4040 ◽  
Author(s):  
WeiHong Ren ◽  
XuRan Zhang ◽  
WenBo Li ◽  
Qian Feng ◽  
HuiJie Feng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Expansion ◽  
Suppressor Cell ◽  
Myeloid Derived Suppressor Cell ◽  
Exosomal Mirna

scholarly journals Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and function

2015 ◽  
Vol 63 (2) ◽  
pp. 579-585 ◽  
Author(s):  
Eva Sahakian ◽  
John J. Powers ◽  
Jie Chen ◽  
Susan L. Deng ◽  
Fengdong Cheng ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Cell Expansion ◽  
Suppressor Cell ◽  
Myeloid Derived Suppressor Cell ◽  
Epigenetic Regulator ◽  
And Function
Sign in / Sign up

Export Citation Format

Share Document