Efficacy and safety of dosage-escalation of low-dosage esaxerenone added to a RAS inhibitor in hypertensive patients with type 2 diabetes and albuminuria: a single-arm, open-label study

Hiroshi Itoh; Sadayoshi Ito; Hiromi Rakugi; Yasuyuki Okuda; Satoshi Nishioka

doi:10.1038/s41440-019-0270-2

Efficacy and safety of dosage-escalation of low-dosage esaxerenone added to a RAS inhibitor in hypertensive patients with type 2 diabetes and albuminuria: a single-arm, open-label study

Hypertension Research ◽

10.1038/s41440-019-0270-2 ◽

2019 ◽

Vol 42 (10) ◽

pp. 1572-1581 ◽

Cited By ~ 9

Author(s):

Hiroshi Itoh ◽

Sadayoshi Ito ◽

Hiromi Rakugi ◽

Yasuyuki Okuda ◽

Satoshi Nishioka

Keyword(s):

Type 2 Diabetes ◽

Efficacy And Safety ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Hypertensive Patients ◽

Dosage Escalation ◽

Low Dosage

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Efficacy and safety of biphasic insulin aspart 30 combined with pioglitazone in type 2 diabetes poorly controlled on glibenclamide (glyburide) monotherapy or combination therapy: An 18-week, randomized, open-label study

Clinical Therapeutics ◽

10.1016/j.clinthera.2005.09.001 ◽

2005 ◽

Vol 27 (9) ◽

pp. 1432-1443 ◽

Cited By ~ 15

Author(s):

Itamar Raz ◽

Stephen Stranks ◽

Robert Filipczak ◽

Pankaj Joshi ◽

Benedikte Lertoft ◽

...

Keyword(s):

Type 2 Diabetes ◽

Combination Therapy ◽

Insulin Aspart ◽

Efficacy And Safety ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Biphasic Insulin ◽

Biphasic Insulin Aspart 30

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A Prospective, Randomized, Open-Label Study Comparing the Efficacy and Safety of Preprandial and Prandial Insulin in Combination with Acarbose in Elderly, Insulin-Requiring Patients with Type 2 Diabetes Mellitus

Diabetes Technology & Therapeutics ◽

10.1089/dia.2012.0275 ◽

2013 ◽

Vol 15 (6) ◽

pp. 513-519 ◽

Cited By ~ 5

Author(s):

Guang Yang ◽

Chunlin Li ◽

Yanping Gong ◽

Jian Li ◽

Xiaoling Cheng ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Efficacy And Safety ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Prandial Insulin

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Efficacy and safety of canagliflozin alone or as add‐on to other oral antihyperglycemic drugs in Japanese patients with type 2 diabetes: A 52‐week open‐label study

Journal of Diabetes Investigation ◽

10.1111/jdi.12266 ◽

2014 ◽

Vol 6 (2) ◽

pp. 210-218 ◽

Cited By ~ 44

Author(s):

Nobuya Inagaki ◽

Kazuoki Kondo ◽

Toru Yoshinari ◽

Hideki Kuki

Keyword(s):

Type 2 Diabetes ◽

Japanese Patients ◽

Efficacy And Safety ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Oral Antihyperglycemic Drugs

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Efficacy and Safety of Prandial Premixed Therapy Using Insulin Lispro Mix 50/50 3 Times Daily Compared With Progressive Titration of Insulin Lispro Mix 75/25 or Biphasic Insulin Aspart 70/30 Twice Daily in Patients With Type 2 Diabetes Mellitus: A Randomized, 16-Week, Open-Label Study

Clinical Therapeutics ◽

10.1016/j.clinthera.2011.10.001 ◽

2011 ◽

Vol 33 (11) ◽

pp. 1682-1693 ◽

Cited By ~ 13

Author(s):

Eugenia Farcasiu ◽

Tibor Ivanyi ◽

Barbara Mozejko-Pastewka ◽

Zita Birkus ◽

Jozsef Csog ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Insulin Lispro ◽

Efficacy And Safety ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Biphasic Insulin

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Comparison of efficacy and safety of empagliflozin vs linagliptin added to premixed insulin in patients with uncontrolled type 2 diabetes: A randomized, open-label study

Diabetes & Metabolism ◽

10.1016/j.diabet.2020.08.001 ◽

2020 ◽

Author(s):

S.-C. Liu ◽

C.-C. Lee ◽

S.-M. Chuang ◽

F.-J. Sun ◽

Y.-H. Zeng

Keyword(s):

Type 2 Diabetes ◽

Efficacy And Safety ◽

Premixed Insulin ◽

Open Label ◽

Open Label Study ◽

Label Study

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Short Term Efficacy and Safety of Insulin Glargine in Type 2 Diabetes Inadequately Controlled with Single or Two Oral Agents: A Prospective, Open Label Study

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2017/27649.10214 ◽

2017 ◽

Author(s):

Ajay Aggarwal

Keyword(s):

Type 2 Diabetes ◽

Insulin Glargine ◽

Efficacy And Safety ◽

Short Term ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Term Efficacy ◽

Oral Agents

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Rationale and Design of the CANONICAL Study　― Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Canagliflozin for Heart Failure With Preserved Ejection Fraction With Type 2 Diabetes Mellitus ―

Circulation Reports ◽

10.1253/circrep.cr-19-0049 ◽

2019 ◽

Vol 1 (8) ◽

pp. 347-351

Author(s):

Shu Kasama ◽

Tohru Masuyama ◽

Shiro Uemura ◽

Yukihito Sato ◽

Shinya Hiramitsu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Heart Failure ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Preserved Ejection Fraction ◽

Efficacy And Safety ◽

Open Label ◽

Open Label Study ◽

Label Study

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Comparative evaluation of efficacy and safety of combination of metformin-vidagliptin versus metfromin-glimepiride in most frequently used doses in patients of type 2 diabetes mellitus with inadequately controlled metformin monotherapy-A randomised open label study

Perspectives in Clinical Research ◽

10.4103/2229-3485.159942 ◽

2015 ◽

Vol 6 (3) ◽

pp. 163

Author(s):

Vijay Khajuria ◽

VishalR Tandon ◽

Annil Mahajan ◽

ZahidH Gillani ◽

Shallini Gupta

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Comparative Evaluation ◽

Efficacy And Safety ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Metformin Monotherapy

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Observational, open-label study of type 1 and type 2 diabetes patients switching from human insulin to insulin analogue basal–bolus regimens: insights from the PREDICTIVE study

Current Medical Research and Opinion ◽

10.1185/03007990903262885 ◽

2009 ◽

Vol 25 (11) ◽

pp. 2601-2608 ◽

Cited By ~ 13

Author(s):

Kjeld Hermansen ◽

Anne Dornhorst ◽

Seamus Sreenan

Keyword(s):

Type 2 Diabetes ◽

Human Insulin ◽

Insulin Analogue ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Basal Bolus ◽

Predictive Study

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Similar progression of diabetic retinopathy with insulin glargine and neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes: a long-term, randomised, open-label study. Reply to Chantelau E [letter] and Currie CJ [letter]

Diabetologia ◽

10.1007/s00125-009-1492-7 ◽

2009 ◽

Vol 52 (10) ◽

pp. 2236-2239

Author(s):

J. Rosenstock ◽

V. Fonseca ◽

J. B. McGill ◽

M. Riddle ◽

J.-P. Hallé ◽

...

Keyword(s):

Type 2 Diabetes ◽

Diabetic Retinopathy ◽

Insulin Glargine ◽

Open Label ◽

Nph Insulin ◽

Open Label Study ◽

Label Study ◽

Neutral Protamine Hagedorn

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Efficacy and safety of dosage-escalation of low-dosage esaxerenone added to a RAS inhibitor in hypertensive patients with type 2 diabetes and albuminuria: a single-arm, open-label study

Efficacy and safety of biphasic insulin aspart 30 combined with pioglitazone in type 2 diabetes poorly controlled on glibenclamide (glyburide) monotherapy or combination therapy: An 18-week, randomized, open-label study

A Prospective, Randomized, Open-Label Study Comparing the Efficacy and Safety of Preprandial and Prandial Insulin in Combination with Acarbose in Elderly, Insulin-Requiring Patients with Type 2 Diabetes Mellitus

Efficacy and safety of canagliflozin alone or as add‐on to other oral antihyperglycemic drugs in Japanese patients with type 2 diabetes: A 52‐week open‐label study

Efficacy and Safety of Prandial Premixed Therapy Using Insulin Lispro Mix 50/50 3 Times Daily Compared With Progressive Titration of Insulin Lispro Mix 75/25 or Biphasic Insulin Aspart 70/30 Twice Daily in Patients With Type 2 Diabetes Mellitus: A Randomized, 16-Week, Open-Label Study

Comparison of efficacy and safety of empagliflozin vs linagliptin added to premixed insulin in patients with uncontrolled type 2 diabetes: A randomized, open-label study

Short Term Efficacy and Safety of Insulin Glargine in Type 2 Diabetes Inadequately Controlled with Single or Two Oral Agents: A Prospective, Open Label Study

Rationale and Design of the CANONICAL Study ― Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Canagliflozin for Heart Failure With Preserved Ejection Fraction With Type 2 Diabetes Mellitus ―

Comparative evaluation of efficacy and safety of combination of metformin-vidagliptin versus metfromin-glimepiride in most frequently used doses in patients of type 2 diabetes mellitus with inadequately controlled metformin monotherapy-A randomised open label study

Observational, open-label study of type 1 and type 2 diabetes patients switching from human insulin to insulin analogue basal–bolus regimens: insights from the PREDICTIVE study

Similar progression of diabetic retinopathy with insulin glargine and neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes: a long-term, randomised, open-label study. Reply to Chantelau E [letter] and Currie CJ [letter]

Rationale and Design of the CANONICAL Study　― Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Canagliflozin for Heart Failure With Preserved Ejection Fraction With Type 2 Diabetes Mellitus ―