scholarly journals Which is the best method in clinical practice for assessing improvement in vascular endothelial function after successful smoking cessation — Flow-mediated dilation (FMD) or reactive hyperemic peripheral arterial tonometry (RH-PAT)?

2020 ◽  
Vol 44 (1) ◽  
pp. 120-121
Author(s):  
Toru Kato
Keyword(s):  
Smoking Cessation ◽  
Clinical Practice ◽  
Endothelial Function ◽  
Flow Mediated Dilation ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Peripheral Arterial Tonometry ◽  
Arterial Tonometry ◽  
Peripheral Arterial

scholarly journals Improvement of Vascular Endothelial Function Reflects Nonrecurrence After Catheter Ablation for Atrial Fibrillation

2021 ◽  
Author(s):  
Hisanori Kanazawa ◽  
Koichi Kaikita ◽  
Miwa Ito ◽  
Yusei Kawahara ◽  
Tadashi Hoshiyama ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Endothelial Function ◽  
Sinus Rhythm ◽  
Reactive Hyperemia ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Peripheral Arterial Tonometry ◽  
Arterial Tonometry ◽  
Peripheral Arterial ◽  
Af Recurrence

Background The clinical implication of vascular endothelial dysfunction in patients with atrial fibrillation (AF) remains unclear. This study aimed to elucidate the correlation between changes in vascular endothelial function assessed by reactive hyperemia‐peripheral arterial tonometry and the effect of sinus rhythm restoration after catheter ablation (CA) for AF. Methods and Results Consecutive 214 patients who underwent CA for AF were included in this single center, retrospective study. The natural logarithmic transformed reactive hyperemia‐peripheral arterial tonometry index (LnRHI) of all patients was measured before CA as well as 3 and 6 months after CA. LnRHI in sinus rhythm was significantly higher than that in AF before CA. Multivariate logistic regression analysis revealed that the presence of AF was an independent risk factor for lowering of LnRHI (odds ratio, 4.092; P =0.002) before CA. The LnRHI was significantly improved 3 and 6 months after CA in patients without AF recurrence. Multivariate Cox hazard analysis revealed that changes in LnRHI from before to 3 months after CA independently correlated with recurrence of AF (hazard ratio, 0.106; P =0.001). Receiver operating characteristic analysis showed the decrease in LnRHI levels from before to 3 months after CA as a significant marker that suspects AF recurrence (area under the curve, 0.792; log‐rank test, P <0.001). Conclusions The presence of AF was independently correlated with the impaired vascular endothelial function assessed by the reactive hyperemia‐peripheral arterial tonometry. Long‐term sinus rhythm restoration after CA for AF might contribute to the improvement of vascular endothelial function, which may reflect the nonrecurrence of AF.

Assessment of Vascular Endothelial Function With Peripheral Arterial Tonometry

2010 ◽  
Vol 18 (1) ◽  
pp. 20-28 ◽  
Author(s):  
Eshan A. Patvardhan ◽  
Kevin S. Heffernan ◽  
Jenny M. Ruan ◽  
Morgan I. Soffler ◽  
Richard H. Karas ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Peripheral Arterial Tonometry ◽  
Arterial Tonometry ◽  
Peripheral Arterial

scholarly journals Does Overnight Duty Affect Vascular Endothelial Function?

2021 ◽  
Author(s):  
A Garu ◽  
Eri Nitta ◽  
Yuri Yoshida ◽  
Erika Yata ◽  
Akari Tsunematsu ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Endothelial Function ◽  
Reactive Hyperemia ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Peripheral Arterial Tonometry ◽  
Vas Score ◽  
Arterial Tonometry ◽  
Lack Of Sleep ◽  
Peripheral Arterial

Abstract Background The reactive hyperemia index (RHI), which is obtained from the measurement of peripheral arterial tonometry (PAT), is highly associated with the percentage change in the end-diastolic arterial diameter (%flow-mediated dilatation) at reactive hyperemia. Low RHI is reported to be a mortality risk in patients with a high risk of cardiovascular (CV) disease. CV events are thought to be induced by physical and mental stress, including long-term fatigue and lack of sleep. However, the relationship between fatigue, lack of sleep, and endothelial function has not yet been established. MethodsHealthy hospital workers (n=13, 6 men and 7 women) with an average age of 31.6 years were assigned to this study after they provided written informed consent. During the study period, we conducted 72 measurements of reactive hyperemia-peripheral arterial tonometry (RH-PAT) in the morning before or after their duty. At each measurement of the RH-PAT, we recorded the participants’ hours of sleep and evaluated their degree of fatigue using a visual analog scale (VAS).ResultsAlthough the VAS was significantly less (36±16% and 64±12%, p<0.001) and the hours of sleep were longer (6.0±1.1 h and 2.3±1.0 h, p<0.001) before duty compared to those after duty, the RHI was comparable between them (2.12±0.53 vs. 1.97±0.50, p=0.21). The VAS score was significantly higher in participants with low RHI (<1.67) than in those with normal RHI (≥2.07) (59±13% and 46±21%, respectively, p<0.05). However, binary logistic regression showed no significant association between low RHI and the VAS when adjusted for systemic blood pressure (SBP) and heart rate variability (HRV). In a simple regression analysis, the RHI was significantly correlated with the VAS score (r=-0.287, p<0.05), while no significant correlation was found between the RHI and sleep duration (r=0.045, p=0.71). A multiple linear regression analysis also showed no significant association between the RHI and VAS scores after adjustment for SBP and HRV.ConclusionsVascular endothelial function was not associated with overnight duty, hours of sleep, or degree of fatigue in healthy young adults. Since the RHI may be decreased in severe fatigue conditions through autonomic nerve activity, one should consider the physical and mental conditions of the examinee when evaluating the RH-PAT results.

scholarly journals Does overnight duty affect vascular endothelial function?

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
A. Garu ◽  
Eri Nitta ◽  
Yuri Yoshida ◽  
Erika Yata ◽  
Akari Tsunematsu ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Endothelial Function ◽  
Reactive Hyperemia ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Peripheral Arterial Tonometry ◽  
Vas Score ◽  
Arterial Tonometry ◽  
Lack Of Sleep ◽  
Peripheral Arterial

Abstract Background The reactive hyperemia index (RHI), which is obtained from the measurement of peripheral arterial tonometry (PAT), is highly associated with the percentage change in the end-diastolic arterial diameter (%flow-mediated dilatation) at reactive hyperemia. Low RHI is reported to be a mortality risk in patients with a high risk of cardiovascular (CV) disease. CV events are thought to be induced by physical and mental stress, including long-term fatigue and lack of sleep. However, the relationship between fatigue, lack of sleep, and endothelial function has not yet been established. Methods Healthy hospital workers (n = 13, 6 men and 7 women) with an average age of 31.6 years were assigned to this study after they provided written informed consent. During the study period, we conducted 72 measurements of reactive hyperemia-peripheral arterial tonometry (RH-PAT) in the morning before or after their duty. At each measurement of the RH-PAT, we recorded the participants’ hours of sleep and evaluated their degree of fatigue using a visual analog scale (VAS). Results Although the VAS was significantly less (36 ± 16% and 64 ± 12%, p < 0.001) and the hours of sleep were longer (6.0 ± 1.1 h and 2.3 ± 1.0 h, p < 0.001) before duty compared to those after duty, the RHI was comparable between them (2.12 ± 0.53 vs. 1.97 ± 0.50, p = 0.21). The VAS score was significantly higher in participants with low RHI (< 1.67) than in those with normal RHI (≥ 2.07) (59 ± 13% and 46 ± 21%, respectively, p < 0.05). However, binary logistic regression showed no significant association between low RHI and the VAS when adjusted for systemic blood pressure (SBP) and heart rate variability (HRV). In a simple regression analysis, the RHI was significantly correlated with the VAS score but not with sleep duration. A multiple linear regression analysis also showed no significant association between the RHI and VAS scores after adjustment for SBP and HRV. Conclusions Vascular endothelial function was not associated with overnight duty, hours of sleep, or degree of fatigue in healthy young adults. Since the RHI may be decreased in severe fatigue conditions through autonomic nerve activity, one should consider the physical and mental conditions of the examinee when evaluating the RH-PAT results.

Abstract MP71: The Association of Vascular Endothelial Tone and Function by Digital Peripheral Arterial Tonometry with Left Ventricular Structure and Function by Cardiac MRI

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Avnish Tripathi ◽  
Solomon K Musani ◽  
Emelia Benjamin ◽  
Koby Sheffy ◽  
Ramachandran S Vasan ◽  
...  
Keyword(s):  
African Americans ◽  
Endothelial Function ◽  
Left Ventricular ◽  
Vascular Endothelial ◽  
Community Based ◽  
Peripheral Arterial Tonometry ◽  
Arterial Tonometry ◽  
Peripheral Arterial ◽  
And Function ◽  
Adjusted Model

Objectives: Higher vascular endothelial tone and impaired endothelial function as assessed by digital peripheral arterial tonometry (PAT) have been associated with increased cardiovascular morbidity and mortality. However, their relation to left ventricular mass (LVM), geometry and systolic function is not known. We examined this relation in a community-based cohort of African Americans. Methods: This study included participants of the Jackson Heart Study who had digital PAT and cardiac magnetic resonance imaging (CMRI) evaluated between 2007- 2013. LVM was adjusted for body size by indexing to height2.7 (LVMI). LVMI was log-transformed within sex and used in the analyses. Age- and sex-adjusted Pearson’s correlations were used to relate baseline pulse amplitude (BPA) and reactive hyperemia index (RHI) (markers of endothelial tone and endothelial function respectively) to LVMI, LV systolic and diastolic volumes (LVSV and LVDV), and stroke volume (SV) by CMRI. Using multivariable adjusted stepwise linear regression with age and sex forced into the model, the relation of PAT parameters to CMRI LV structure and function was evaluated adjusting for body mass index, systolic blood pressure, diabetes mellitus, and total cholesterol: HDL ratio. Results: The study population consisted of 440 participants [mean age 59 ± 10 years, 263 (60%) women]. Higher BPA (increased endothelial tone) was significantly and positively correlated with log-LVMI (0.272; p <0.001). Higher RHI (improved endothelial function) was significantly and negatively correlated with log-LVMI (-0.114; p <0.018). In age-sex adjusted models both higher BPA (β = 0.064, SE = 0.011, p < 0.001) and lower RHI (β = -0.069, SE = 0.029, p = 0.018) were significantly related to higher log-LVMI. In the multivariable analyses higher BPA (β = 0.022, SE = 0.010, p = 0.023) but not RHI (p > 0.05) was significantly associated with higher log-LVMI. BPA explained approximately 11% of the total variation of log-LVMI. PAT parameters were not significantly associated with LV volumes or cardiac function parameters in the multivariable analysis. Conclusions: In a community-based sample of African Americans higher endothelial tone measured by digital PAT was significantly associated with higher LVMI by CMRI after adjusting for traditional risk factors. Better endothelial function was correlated with lower LVMI and was significantly associated with lower LVMI in the age-sex adjusted model but not the fully adjusted model. These findings suggest that endothelial tone may be one of the potential determinants of LV hypertrophy in African Americans.

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