scholarly journals Lying in wait: the resurgence of dengue virus after the Zika epidemic in Brazil

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Anderson Fernandes Brito ◽  
Lais Ceschini Machado ◽  
Rachel J. Oidtman ◽  
Márcio Junio Lima Siconelli ◽  
Quan Minh Tran ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Protective Immunity ◽  
Local Conditions ◽  
Force Of Infection ◽  
Viral Spread ◽  
Virus Serotype ◽  
Before And After ◽  
Serotype 1 ◽  
Marked Decline ◽  
Dengue Virus Serotype 1

AbstractAfter the Zika virus (ZIKV) epidemic in the Americas in 2016, both Zika and dengue incidence declined to record lows in many countries in 2017–2018, but in 2019 dengue resurged in Brazil, causing ~2.1 million cases. In this study we use epidemiological, climatological and genomic data to investigate dengue dynamics in recent years in Brazil. First, we estimate dengue virus force of infection (FOI) and model mosquito-borne transmission suitability since the early 2000s. Our estimates reveal that DENV transmission was low in 2017–2018, despite conditions being suitable for viral spread. Our study also shows a marked decline in dengue susceptibility between 2002 and 2019, which could explain the synchronous decline of dengue in the country, partially as a result of protective immunity from prior ZIKV and/or DENV infections. Furthermore, we performed phylogeographic analyses using 69 newly sequenced genomes of dengue virus serotype 1 and 2 from Brazil, and found that the outbreaks in 2018–2019 were caused by local DENV lineages that persisted for 5–10 years, circulating cryptically before and after the Zika epidemic. We hypothesize that DENV lineages may circulate at low transmission levels for many years, until local conditions are suitable for higher transmission, when they cause major outbreaks.

scholarly journals Lying in wait: the resurgence of dengue virus after the Zika epidemic in Brazil

2020 ◽  
Author(s):  
Anderson Fernandes Brito ◽  
Lais Ceschini Machado ◽  
Marcio Junio Lima Siconelli ◽  
Rachel J. Oidtman ◽  
Joseph R. Fauver ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Susceptible Population ◽  
Climatological Data ◽  
Low Transmission ◽  
Force Of Infection ◽  
Viral Spread ◽  
Virus Serotype ◽  
Dengue Outbreaks ◽  
Serotype 1 ◽  
Low Incidence

After Zika virus (ZIKV) emerged and caused an epidemic in the Americas in 2016, both Zika and dengue incidence declined in the following years (2017-2018) to a record low in many countries. Following this period of low incidence, dengue resurged in 2019 in Brazil, causing ~2.1 million cases. The reasons for the recent fluctuations in dengue incidence and the maintenance of dengue virus (DENV) through periods of low transmission are unknown. To investigate this, we used a combination of epidemiological and climatological data to estimate dengue force of infection (FOI) and model mosquito-borne transmission suitability since the early 2000s in Brazil. Our estimates of FOI revealed that the rate of DENV transmission in 2018-2019 was exceptionally low, due to a low proportion of susceptible population rather than changes to ecological conditions. This supports the hypothesis that the synchronous decline of dengue in Brazil may be explained by protective immunity from pre-exposure to ZIKV and/or DENV in prior years. Furthermore, we sequenced 69 genomes of dengue virus serotype 1 (DENV-1) and DENV-2 circulating in Northeast and Southeast Brazil, and performed phylogeographic analyses to uncover patterns of viral spread. We found that the outbreaks in Brazil in 2019 were caused by DENV lineages that were circulating locally prior to the Zika epidemic and spread cryptically during the period of low transmission. Despite the period of low transmission, endemic DENV lineages persisted for 5-10 years in Brazil before causing major outbreaks. Our study challenges the paradigm that dengue outbreaks are caused by recently introduced new lineages, but rather they may be driven by established lineages circulating at low levels until the conditions are conducive for outbreaks.

Force of infection of dengue serotypes in a population-based study in the northeast of Brazil

2012 ◽  
Vol 141 (5) ◽  
pp. 1080-1088 ◽  
Author(s):  
P. M. S. CASTANHA ◽  
M. T. CORDEIRO ◽  
C. M. T. MARTELLI ◽  
W. V. SOUZA ◽  
E. T. A. MARQUES ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Dengue Infection ◽  
Population Based ◽  
Northeastern Brazil ◽  
Population Based Study ◽  
Force Of Infection ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Frequent Infection ◽  
Dengue Virus Serotype 1

SUMMARYThis study investigated anti-dengue serotype-specific neutralizing antibodies in a random sample of dengue IgG-positive individuals identified in a survey performed in a hyperendemic setting in northeastern Brazil in 2005. Of 323 individuals, 174 (53·8%) had antibodies to dengue virus serotype 1 (DENV-1), 104 (32·2%) to DENV-2 and 301 (93·2%) to DENV-3. Monotypic infections by DENV-3 were the most frequent infection (35·6%). Of 109 individuals aged <15 years, 61·5% presented multitypic infections. The force of infection estimated by a catalytic model was 0·9%, 0·4% and 2·5% person-years for DENV-1, DENV-2 and DENV-3, respectively. By the age of 5 years, about 70%, 30% and 40% of participants were immune to DENV-3, DENV-2 and DENV-1, respectively. The data suggest that infection with DENV-1, -2 and -3 is intense at early ages, demonstrating the need for research efforts to investigate dengue infection in representative population samples of Brazilian children during early infancy.

Induction of multiple cytotoxic T lymphocyte responses in mice by a multiepitope DNA vaccine against dengue virus serotype 1

2016 ◽  
Vol 60 (12) ◽  
pp. 835-845 ◽  
Author(s):  
Xin Yu Chen ◽  
De Zhou Li ◽  
Xiao Zhi Zhong ◽  
Bokun Chen ◽  
Zhi Liang Duan ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Dna Vaccine ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Lymphocyte Responses ◽  
Dengue Virus Serotype 1

scholarly journals Safety and Immunogenicity of a Dengue Virus Serotype-1 Purified-Inactivated Vaccine: Results of a Phase 1 Clinical Trial

2015 ◽  
Vol 93 (3) ◽  
pp. 454-460 ◽  
Author(s):  
Luis Javier Martinez ◽  
Leyi Lin ◽  
Jason M. Blaylock ◽  
Arthur G. Lyons ◽  
Kristen M. Bauer ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Dengue Virus ◽  
Phase 1 ◽  
Inactivated Vaccine ◽  
Phase 1 Clinical Trial ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Dengue Virus Serotype 1

scholarly journals Rapid Subtyping of Dengue Virus Serotypes 1 and 4 by Restriction Site-Specific PCR

2000 ◽  
Vol 38 (3) ◽  
pp. 1286-1289 ◽  
Author(s):  
Marize P. Miagostovich ◽  
Flavia B. dos Santos ◽  
C. Milena Gutiérrez ◽  
Lee W. Riley ◽  
Eva Harris
Keyword(s):  
Sequence Analysis ◽  
Dengue Virus ◽  
Restriction Site ◽  
Epidemiological Studies ◽  
Site Specific ◽  
Specific Pcr ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Dengue Virus Serotypes ◽  
Dengue Virus Serotype 1

We previously reported a simple subtyping method, restriction site-specific PCR (RSS-PCR), for dengue virus serotypes 2 and 3; here we describe its application for subtyping dengue virus serotypes 1 and 4. Three major RSS-PCR types were observed for dengue virus serotype 1 and two types were observed for dengue virus serotype 4, in agreement with previous strain classifications based on sequence analysis. Because of its simplicity, this method is amenable to rapid subtyping and application to epidemiological studies of dengue in countries where dengue is endemic.

scholarly journals Complete Genome Sequence Analysis of an Imported Dengue Virus Serotype 1 Strain from Myanmar

2018 ◽  
Vol 6 (27) ◽  
Author(s):  
Zhaoping Zeng ◽  
Jiandong Shi ◽  
Xiaofang Guo ◽  
Ling Mo ◽  
Ningzhu Hu ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Genome Sequence Analysis ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Complete Genome Sequence Analysis ◽  
Dengue Virus Serotype 1

It has been determined that recent dengue virus epidemics in Yunnan, China, originated from Southeast Asian strains. Here, we report the first complete genome sequence and molecular characterization of the imported dengue virus serotype 1 strain YNPE1.

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