scholarly journals Expanding global access to genetic therapies

Anne W. T. Muigai
2021 ◽  
pp. 026666692110154
Usman Ahmed Adam ◽  
Kiran Kaur

Institutional repositories are powerful tools to facilitate global access to intellectual output by members of the institution, particularly in assisting them to preserve and maximize access to their research output globally. This exploratory study of the status of institutional repositories implementation in African countries using the global Directory of Open Access Repositories (OpenDOAR) and Transparent Ranking: All Repositories by Google Scholar, reports on the operational status and the performance of repositories. Factor analysis and cluster analysis are used to analyze the operational level of institutional repositories in African countries. The analysis showed that the typical performance of institutional repositories remains below average. The possibility of global open access to research results through institutional repositories in South Africa, Kenya, Nigeria, Algeria, Sudan, and Egypt appeared to be relatively more feasible than other African countries. This study concludes that many organizations, institutions, and societies spend great efforts in support of open access implementation in Africa, however, the widespread implementation of institutional repositories is still very slow paced, and the performance of the implemented repositories was below expectation. Suggestions for regaining the intended direction of African institutional repositories are given based on the current status.

2020 ◽  
Vol 6 (10) ◽  
pp. eaau4819 ◽  
Irnela Bajrovic ◽  
Stephen C. Schafer ◽  
Dwight K. Romanovicz ◽  
Maria A. Croyle

A novel, thin-film platform that preserves live viruses, bacteria, antibodies, and enzymes without refrigeration for extended periods of time is described. Studies with recombinant adenovirus in an optimized formulation that supports recovery of live virus through 16 freeze-thaw cycles revealed that production of an amorphous solid with a glass transition above room temperature and nitrogen-hydrogen bonding between virus and film components are critical determinants of stability. Administration of live influenza virus in the optimized film by the sublingual and buccal routes induced antibody-mediated immune responses as good as or better than those achieved by intramuscular injection. This work introduces the possibility of improving global access to a variety of medicines by offering a technology capable of reducing costs of production, distribution, and supply chain maintenance.

2015 ◽  
Vol 16 (10) ◽  
pp. 1148-1149 ◽  
Philip Poortmans ◽  
Vincenzo Valentini ◽  
Yolande Lievens

2021 ◽  
Vol 24 ◽  
pp. S204
C. Poschen ◽  
S. Anwar ◽  
R. Macaulay

2015 ◽  
Vol 29 (2) ◽  
pp. 79-85 ◽  
Debra Ainge ◽  
Suzanne Aitken ◽  
Mark Corbett ◽  
David De-Keyzer

2012 ◽  
pp. 265-269
B Simons ◽  
O Raymond ◽  
I Jackson ◽  
K Lee

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