Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

Irene Miguel-Escalada; Silvia Bonàs-Guarch; Inês Cebola; Joan Ponsa-Cobas; Julen Mendieta-Esteban; Goutham Atla; Biola M. Javierre; Delphine M. Y. Rolando; Irene Farabella; Claire C. Morgan; Javier García-Hurtado; Anthony Beucher; Ignasi Morán; Lorenzo Pasquali; Mireia Ramos-Rodríguez; Emil V. R. Appel; Allan Linneberg; Anette P. Gjesing; Daniel R. Witte; Oluf Pedersen; Niels Grarup; Philippe Ravassard; David Torrents; Josep M. Mercader; Lorenzo Piemonti; Thierry Berney; Eelco J. P. de Koning; Julie Kerr-Conte; François Pattou; Iryna O. Fedko; Leif Groop; Inga Prokopenko; Torben Hansen; Marc A. Marti-Renom; Peter Fraser; Jorge Ferrer

doi:10.1038/s41588-019-0457-0

Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

Nature Genetics ◽

10.1038/s41588-019-0457-0 ◽

2019 ◽

Vol 51 (7) ◽

pp. 1137-1148 ◽

Cited By ~ 55

Author(s):

Irene Miguel-Escalada ◽

Silvia Bonàs-Guarch ◽

Inês Cebola ◽

Joan Ponsa-Cobas ◽

Julen Mendieta-Esteban ◽

...

Keyword(s):

Type 2 Diabetes ◽

Pancreatic Islet ◽

Three Dimensional ◽

Human Pancreatic Islet ◽

Chromatin Architecture

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Faculty Opinions recommendation of Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.736064143.793564083 ◽

2019 ◽

Author(s):

Salvatore Spicuglia

Keyword(s):

Type 2 Diabetes ◽

Pancreatic Islet ◽

Three Dimensional ◽

Human Pancreatic Islet ◽

Chromatin Architecture

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Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes

10.1242/prelights.4848 ◽

2018 ◽

Author(s):

Carmen Adriaens

Keyword(s):

Type 2 Diabetes ◽

Pancreatic Islet ◽

Human Pancreatic Islet ◽

Chromatin Architecture

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Decision letter: Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

10.7554/elife.31977.046 ◽

2017 ◽

Keyword(s):

Type 2 Diabetes ◽

Pancreatic Islet ◽

Genomic Data ◽

Regulatory Mechanisms ◽

Susceptibility Loci ◽

Diabetes Susceptibility ◽

Human Pancreatic Islet

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4Pi microscopy reveals an impaired three-dimensional mitochondrial network of pancreatic islet β-cells, an experimental model of type-2 diabetes

Biochimica et Biophysica Acta (BBA) - Bioenergetics ◽

10.1016/j.bbabio.2010.02.003 ◽

2010 ◽

Vol 1797 (6-7) ◽

pp. 1327-1341 ◽

Cited By ~ 39

Author(s):

Andrea Dlasková ◽

Tomáš Špaček ◽

Jitka Šantorová ◽

Lydie Plecitá-Hlavatá ◽

Zuzana Berková ◽

...

Keyword(s):

Type 2 Diabetes ◽

Experimental Model ◽

Pancreatic Islet ◽

Three Dimensional ◽

Mitochondrial Network ◽

Β Cells ◽

4Pi Microscopy

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Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes

Nature Metabolism ◽

10.1038/s42255-021-00420-9 ◽

2021 ◽

Cited By ~ 1

Author(s):

Leonore Wigger ◽

Marko Barovic ◽

Andreas-David Brunner ◽

Flavia Marzetta ◽

Eyke Schöniger ◽

...

Keyword(s):

Type 2 Diabetes ◽

Beta Cell ◽

Pancreatic Islet ◽

Human Pancreatic Islet ◽

Cell Trajectories

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Author response: Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

10.7554/elife.31977.047 ◽

2018 ◽

Author(s):

Matthias Thurner ◽

Martijn van de Bunt ◽

Jason M Torres ◽

Anubha Mahajan ◽

Vibe Nylander ◽

...

Keyword(s):

Type 2 Diabetes ◽

Pancreatic Islet ◽

Genomic Data ◽

Regulatory Mechanisms ◽

Author Response ◽

Susceptibility Loci ◽

Diabetes Susceptibility ◽

Human Pancreatic Islet

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The reproducibility of acquiring three dimensional gait and plantar pressure data using established protocols in participants with and without type 2 diabetes and foot ulcers

Journal of Foot and Ankle Research ◽

10.1186/s13047-016-0135-8 ◽

2016 ◽

Vol 9 (1) ◽

Cited By ~ 13

Author(s):

Malindu Fernando ◽

Robert G Crowther ◽

Margaret Cunningham ◽

Peter A Lazzarini ◽

Kunwarjit S Sangla ◽

...

Keyword(s):

Type 2 Diabetes ◽

Plantar Pressure ◽

Three Dimensional ◽

Foot Ulcers ◽

Pressure Data

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Assessment of left ventricular function by three-dimensional speckle-tracking echocardiography in well-treated type 2 diabetes patients with or without hypertension

Journal of Clinical Ultrasound ◽

10.1002/jcu.22268 ◽

2015 ◽

Vol 43 (8) ◽

pp. 502-511 ◽

Cited By ~ 15

Author(s):

Qingqing Wang ◽

Yunhua Gao ◽

Kaibin Tan ◽

Hongmei Xia ◽

Peijing Li

Keyword(s):

Type 2 Diabetes ◽

Left Ventricular Function ◽

Ventricular Function ◽

Speckle Tracking ◽

Speckle Tracking Echocardiography ◽

Three Dimensional ◽

Left Ventricular ◽

Diabetes Patients

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MicroRNA Networks in Pancreatic Islet Cells: Normal Function and Type 2 Diabetes

Diabetes ◽

10.2337/dbi19-0016 ◽

2020 ◽

Vol 69 (5) ◽

pp. 804-812 ◽

Cited By ~ 2

Author(s):

Lena Eliasson ◽

Jonathan L.S. Esguerra

Keyword(s):

Type 2 Diabetes ◽

Pancreatic Islet ◽

Islet Cells ◽

Normal Function ◽

Pancreatic Islet Cells ◽

Microrna Networks

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Effect of cilostazol on carotid plaque volume measured by three‐dimensional ultrasonography in patients with type 2 diabetes: The FANCY study

Diabetes Obesity and Metabolism ◽

10.1111/dom.14147 ◽

2020 ◽

Vol 22 (12) ◽

pp. 2257-2266

Author(s):

Dong‐Hwa Lee ◽

Eun Ju Chun ◽

Ji Hye Moon ◽

Han Mi Yun ◽

Soo Lim

Keyword(s):

Type 2 Diabetes ◽

Carotid Plaque ◽

Three Dimensional ◽

Plaque Volume

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