scholarly journals Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Felicia Gilels ◽  
Stephen T. Paquette ◽  
Holly J. Beaulac ◽  
Anwen Bullen ◽  
Patricia M. White
2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Anni Herranen ◽  
Kuu Ikäheimo ◽  
Tuuli Lankinen ◽  
Emmi Pakarinen ◽  
Bernd Fritzsch ◽  
...  

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e53280 ◽  
Author(s):  
Mark A. Crumling ◽  
Liqian Liu ◽  
Paul V. Thomas ◽  
Jennifer Benson ◽  
Ariane Kanicki ◽  
...  

2006 ◽  
Vol 211 (1-2) ◽  
pp. 85-95 ◽  
Author(s):  
Weiju Han ◽  
Xiaorui Shi ◽  
Alfred L. Nuttall

2010 ◽  
Vol 5 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Han Wei–ju ◽  
Shi Xiao–rui ◽  
Alfred Nuttall

2008 ◽  
Vol 245 (1-2) ◽  
pp. 48-57 ◽  
Author(s):  
Bo Hua Hu ◽  
Wei-Ping Yang ◽  
Eric C. Bielefeld ◽  
Manna Li ◽  
Guang-Di Chen ◽  
...  

Neuroreport ◽  
2019 ◽  
Vol 30 (3) ◽  
pp. 145-150 ◽  
Author(s):  
Bo Li ◽  
Tihua Zheng ◽  
Caifang Yan ◽  
Wenjun Wang ◽  
Jinjin Zhang ◽  
...  

2009 ◽  
Vol 14 (4) ◽  
pp. 427-437 ◽  
Author(s):  
Mona Taleb ◽  
Carlene S. Brandon ◽  
Fu-Shing Lee ◽  
Kelly C. Harris ◽  
Wolfgang H. Dillmann ◽  
...  

Neuroscience ◽  
2016 ◽  
Vol 316 ◽  
pp. 311-320 ◽  
Author(s):  
J. Hu ◽  
M. Xu ◽  
J. Yuan ◽  
B. Li ◽  
S. Entenman ◽  
...  

2019 ◽  
Author(s):  
Viacheslav Vasilkov ◽  
Sarah Verhulst

AbstractDamage to the auditory periphery is more widespread than predicted by the gold-standard clinical audiogram. Noise exposure, ototoxicity and aging can destroy cochlear inner-hair-cell afferent synapses and result in a degraded subcortical representation of sound while leaving hearing thresholds unaffected. Damaged afferent synapses, i.e. cochlear synaptopathy, can be quantified using histology, but a differential diagnosis in living humans is difficult: histology cannot be applied and existing auditory evoked potential (AEP) metrics for synaptopathy become insensitive when other sensorineural hearing impairments co-exist (e.g., outer-hair-cell damage associated with elevated hearing thresholds). To develop a non-invasive diagnostic method which quantifies synaptopathy in humans and animals with normal or elevated hearing thresholds, we employ a computational model approach in combination with human AEP and psychoacoustics. We propose the use of a sensorineural hearing loss (SNHL) map which comprises two relative AEP-based metrics to quantify the respective degrees of synaptopathy and OHC damage and evaluate to which degree our predictions of AEP alterations can explain individual data-points in recorded SNHL maps from male and female listeners with normal or elevated audiometric thresholds. We conclude that SNHL maps can offer a more precise diagnostic tool than existing AEP methods for individual assessment of the synaptopathy and OHC-damage aspect of sensorineural hearing loss.Significance StatementHearing loss ranks fourth in global causes for disability and risk factors include noise exposure, ototoxicity and aging. The most vulnerable parts of the cochlea are the inner-hair-cell afferent synapses and their damage (cochlear synaptopathy) results in a degraded subcortical representation of sound. While synaptopathy can be estimated reliably using histology, it cannot be quantified this way in living humans. Secondly, other co-existing sensorineural hearing deficits (e.g., outer-hair-cell damage) can complicate a differential diagnosis. To quantify synaptopathy in humans and animals with normal or elevated hearing thresholds, we adopt a theoretical and interdisciplinary approach. Sensitive diagnostic metrics for synaptopathy are crucial to assess its prevalence in humans, study its impact on sound perception and yield effective hearing restoration strategies.


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