scholarly journals Early detection of pulmonary exacerbations in children with Cystic Fibrosis by electronic home monitoring of symptoms and lung function

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Marieke van Horck ◽  
Bjorn Winkens ◽  
Geertjan Wesseling ◽  
Dillys van Vliet ◽  
Kim van de Kant ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Early Detection ◽  
Home Monitoring ◽  
Pulmonary Exacerbations

scholarly journals Publisher Correction: Early detection of pulmonary exacerbations in children with Cystic Fibrosis by electronic home monitoring of symptoms and lung function

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Marieke van Horck ◽  
Bjorn Winkens ◽  
Geertjan Wesseling ◽  
Dillys van Vliet ◽  
Kim van de Kant ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Early Detection ◽  
Home Monitoring ◽  
Pulmonary Exacerbations

scholarly journals ePS05.6 Early detection of pulmonary exacerbations in children with cystic fibrosis by electronic home monitoring of symptoms and lung function

2016 ◽  
Vol 15 ◽  
pp. S47
Author(s):  
M. van Horck ◽  
B. Winkens ◽  
G. Wesseling ◽  
K. van de Kant ◽  
K.M. de Winter-de Groot ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Early Detection ◽  
Home Monitoring ◽  
Pulmonary Exacerbations

scholarly journals Early Detection of Lung Disease in Children with Cystic Fibrosis Using Lung Function

2008 ◽  
Vol 9 (3) ◽  
pp. 160-167 ◽  
Author(s):  
Sarath Ranganathan ◽  
Barry Linnane ◽  
Gary Nolan ◽  
Catherine Gangell ◽  
Graham Hall
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Early Detection ◽  
Lung Disease

Feasibility of Early Detection of Cystic Fibrosis Acute Pulmonary Exacerbations by Exhaled Breath Condensate Metabolomics: A Pilot Study

2016 ◽  
Vol 16 (2) ◽  
pp. 550-558 ◽  
Author(s):  
Xiaoling Zang ◽  
María Eugenia Monge ◽  
Nael A. McCarty ◽  
Arlene A. Stecenko ◽  
Facundo M. Fernández
Keyword(s):  
Cystic Fibrosis ◽  
Pilot Study ◽  
Early Detection ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Pulmonary Exacerbations ◽  
Breath Condensate

scholarly journals Pseudomonas aeruginosa Susceptibility Patterns and Associated Clinical Outcomes in People with Cystic Fibrosis following Approval of Aztreonam Lysine for Inhalation

2020 ◽  
pp. AAC.02327-20 ◽  
Author(s):  
Claire L Keating ◽  
Jonathan B Zuckerman ◽  
Pradeep K Singh ◽  
Matthew McKevitt ◽  
Oksana Gurtovaya ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Lung Function ◽  
Clinical Outcomes ◽  
Primary Endpoint ◽  
The United States ◽  
Study Endpoint ◽  
Primary Study ◽  
Antibiotic Exposure ◽  
Pulmonary Exacerbations

Rationale: Approval of aztreonam lysine for inhalation solution (AZLI) raised concerns that additional antibiotic exposure would potentially affect susceptibility profiles of Pseudomonas aeruginosa (PA) isolates from cystic fibrosis (CF) patients.Objective: This 5-year, prospective, observational study tracked susceptibility changes and clinical outcomes in CF patients in the United States with chronic PA infection.Methods: Sputum cultures were collected annually (2011-2016). The primary study endpoint was the proportion of subjects whose least susceptible PA isolate had an aztreonam minimum inhibitory concentration (MIC) that was >8 μg/mL (parenteral breakpoint) and increased ≥4-fold compared with the least susceptible isolate from the previous year. Annualized data for pulmonary exacerbations, hospitalizations, and FEV1% predicted were obtained from the CF Foundation Patient Registry and compared between subjects meeting/not meeting the primary endpoint.Results: 510 subjects were enrolled; 334 (65%) completed the study. A consistent proportion of evaluable subjects (13-22%) met the primary endpoint each year; and AZLI use during the previous 12 months was not associated with meeting the primary endpoint. While the annual decline in lung function was comparable for subjects meeting/not meeting the primary endpoint, more pulmonary exacerbations and hospitalizations were experienced by those who met it.Conclusions: Aztreonam susceptibility of PA remained consistent during the 5-year study. The relationship between PA isolate susceptibilities and clinical outcomes is complex; reduced susceptibility was not associated with accelerated decline in lung function, but was associated with more exacerbations and hospitalizations, likely reflecting increased overall antibiotic exposure.

scholarly journals Smartphone-Based pH Sensor for Home Monitoring of Pulmonary Exacerbations in Cystic Fibrosis

Sensors ◽  
2017 ◽  
Vol 17 (6) ◽  
pp. 1245 ◽  
Author(s):  
Alexander Sun ◽  
Tom Phelps ◽  
Chengyang Yao ◽  
A. Venkatesh ◽  
Douglas Conrad ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Ph Sensor ◽  
Home Monitoring ◽  
Pulmonary Exacerbations
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