scholarly journals The morphology of antennal lobe projection neurons is controlled by a POU-domain transcription factor Bmacj6 in the silkmoth Bombyx mori

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Shigehiro Namiki ◽  
Tsuguru Fujii ◽  
Toru Shimada ◽  
Ryohei Kanzaki
Keyword(s):  
Transcription Factor ◽  
Bombyx Mori ◽  
Antennal Lobe ◽  
Projection Neurons ◽  
Pou Domain

Morphology and physiology of antennal lobe projection neurons in the hawkmoth Agrius convolvuli

2017 ◽  
Vol 98 ◽  
pp. 214-222 ◽  
Author(s):  
Takuya Nirazawa ◽  
Takeshi Fujii ◽  
Yoichi Seki ◽  
Shigehiro Namiki ◽  
Tomoki Kazawa ◽  
...  
Keyword(s):  
Antennal Lobe ◽  
Projection Neurons

Temporal summation properties of the olfactory projection neurons in the moth antennal lobe revealed by optogenetic stimulation

2011 ◽  
Vol 71 ◽  
pp. e79
Author(s):  
Masashi Tabuchi ◽  
Takeshi Sakurai ◽  
Hidefumi Mitsuno ◽  
Shigehiro Namiki ◽  
Ryo Minegishi ◽  
...  
Keyword(s):  
Antennal Lobe ◽  
Temporal Summation ◽  
Projection Neurons ◽  
Optogenetic Stimulation

scholarly journals BRN2 is a non-canonical melanoma tumor-suppressor

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Michael Hamm ◽  
Pierre Sohier ◽  
Valérie Petit ◽  
Jérémy H. Raymond ◽  
Véronique Delmas ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Transcription Factors ◽  
Tumor Suppressor ◽  
The Other ◽  
Pi3k Signaling ◽  
Melanoma Tumor ◽  
Temporal Regulation ◽  
Metastatic Colonization ◽  
Pou Domain

AbstractWhile the major drivers of melanoma initiation, including activation of NRAS/BRAF and loss of PTEN or CDKN2A, have been identified, the role of key transcription factors that impose altered transcriptional states in response to deregulated signaling is not well understood. The POU domain transcription factor BRN2 is a key regulator of melanoma invasion, yet its role in melanoma initiation remains unknown. Here, in a BrafV600EPtenF/+ context, we show that BRN2 haplo-insufficiency promotes melanoma initiation and metastasis. However, metastatic colonization is less efficient in the absence of Brn2. Mechanistically, BRN2 directly induces PTEN expression and in consequence represses PI3K signaling. Moreover, MITF, a BRN2 target, represses PTEN transcription. Collectively, our results suggest that on a PTEN heterozygous background somatic deletion of one BRN2 allele and temporal regulation of the other allele elicits melanoma initiation and progression.

scholarly journals Basic Helix-Loop-Helix Transcription Factor Bmsage Is Involved in Regulation of fibroin H-chain Gene via Interaction with SGF1 in Bombyx mori

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e94091 ◽  
Author(s):  
Xiao-Ming Zhao ◽  
Chun Liu ◽  
Qiong-Yan Li ◽  
Wen-Bo Hu ◽  
Meng-Ting Zhou ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Bombyx Mori ◽  
Chain Gene ◽  
Basic Helix Loop Helix ◽  
Helix Loop Helix

Characterisation of cis-acting sequences reveals a biphasic, axon-dependent regulation of Krox20 during Schwann cell development

Development ◽  
2002 ◽  
Vol 129 (1) ◽  
pp. 155-166 ◽  
Author(s):  
Julien Ghislain ◽  
Carole Desmarquet-Trin-Dinh ◽  
Martine Jaegle ◽  
Dies Meijer ◽  
Patrick Charnay ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Schwann Cell ◽  
Dependent Manner ◽  
Cis Acting ◽  
Pou Domain ◽  
Cell Element ◽  
Schwann Cell Development ◽  
Myelinating Schwann Cell ◽  
Sciatic Nerve Regeneration

In Schwann cells (SC), myelination is controlled by the transcription factor gene Krox20/Egr2. Analysis of cis-acting elements governing Krox20 expression in SC revealed the existence of two separate elements. The first, designated immature Schwann cell element (ISE), was active in immature but not myelinating SC, whereas the second, designated myelinating Schwann cell element (MSE), was active from the onset of myelination to adulthood in myelinating SC. In vivo sciatic nerve regeneration experiments demonstrated that both elements were activated during this process, in an axon-dependent manner. Together the activity of these elements reproduced the profile of Krox20 expression during development and regeneration. Genetic studies showed that both elements were active in a Krox20 mutant background, while the activity of the MSE, but likely not of the ISE, required the POU domain transcription factor Oct6 at the time of myelination. The MSE was localised to a 1.3 kb fragment, 35 kb downstream of Krox20. The identification of multiple Oct6 binding sites within this fragment suggested that Oct6 directly controls Krox20 transcription. Taken together, these data indicate that, although Krox20 is expressed continuously from 15.5 dpc in SC, the regulation of its expression is a biphasic, axon-dependent phenomenon involving two cis-acting elements that act in succession during development. In addition, they provide insight into the complexity of the transcription factor regulatory network controlling myelination.

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