scholarly journals Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Selen Atasoy ◽  
Leor Roseman ◽  
Mendel Kaelen ◽  
Morten L. Kringelbach ◽  
Gustavo Deco ◽  
...  
2017 ◽  
Author(s):  
Selen Atasoy ◽  
Leor Roseman ◽  
Mendel Kaelen ◽  
Morten L. Kringelbach ◽  
Gustavo Deco ◽  
...  

ABSTRACTRecent studies have started to elucidate the effects of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet fully understood. Here we used ‘connectome-harmonic decomposition’, a novel method to investigate the dynamical changes in brain states. We found that LSD alters the energy and the power of individual harmonic brain states in a frequency-selective manner. Remarkably, this leads to an expansion of the repertoire of active brain states, suggestive of a general re-organization of brain dynamics given the non-random increase in co-activation across frequencies. Interestingly, the frequency distribution of the active repertoire of brain states under LSD closely follows power-laws indicating a re-organization of the dynamics at the edge of criticality. Beyond the present findings, these methods open up for a better understanding of the complex brain dynamics in health and disease.


Author(s):  
A.I. Luppi ◽  
J. Vohryzek ◽  
M.L. Kringelbach ◽  
P.A.M. Mediano ◽  
M.M. Craig ◽  
...  

ABSTRACTA central question in neuroscience is how cognition and consciousness arise from human brain activity. Here, we decompose cortical dynamics of resting-state functional MRI into their constituent elements: the harmonics of the human connectome. Mapping a wide spectrum of consciousness onto these elementary brain states reveals a generalisable connectome harmonic signature of loss of consciousness, whether due to anaesthesia or severe brain injury. Remarkably, its mirror-reversed image corresponds to the harmonic signature of the psychedelic state induced by ketamine or LSD, identifying meaningful relationships between neurobiology, brain function, and conscious experience. The repertoire of connectome harmonics further provides a fine-tuned indicator of level of consciousness, sensitive to differences in anaesthetic dose and clinically relevant sub-categories of patients with disorders of consciousness. Overall, we reveal that the emergence of consciousness from human brain dynamics follows the same universal principles shared by a multitude of physical and biological phenomena: the mathematics of harmonic modes.


2019 ◽  
Vol 9 (22) ◽  
pp. 4749
Author(s):  
Lingyun Jiang ◽  
Kai Qiao ◽  
Linyuan Wang ◽  
Chi Zhang ◽  
Jian Chen ◽  
...  

Decoding human brain activities, especially reconstructing human visual stimuli via functional magnetic resonance imaging (fMRI), has gained increasing attention in recent years. However, the high dimensionality and small quantity of fMRI data impose restrictions on satisfactory reconstruction, especially for the reconstruction method with deep learning requiring huge amounts of labelled samples. When compared with the deep learning method, humans can recognize a new image because our human visual system is naturally capable of extracting features from any object and comparing them. Inspired by this visual mechanism, we introduced the mechanism of comparison into deep learning method to realize better visual reconstruction by making full use of each sample and the relationship of the sample pair by learning to compare. In this way, we proposed a Siamese reconstruction network (SRN) method. By using the SRN, we improved upon the satisfying results on two fMRI recording datasets, providing 72.5% accuracy on the digit dataset and 44.6% accuracy on the character dataset. Essentially, this manner can increase the training data about from n samples to 2n sample pairs, which takes full advantage of the limited quantity of training samples. The SRN learns to converge sample pairs of the same class or disperse sample pairs of different class in feature space.


Science ◽  
2020 ◽  
Vol 367 (6482) ◽  
pp. 1086.8-1087
Author(s):  
Peter Stern
Keyword(s):  

1988 ◽  
Vol 35 (11) ◽  
pp. 960-966 ◽  
Author(s):  
J.C. de Munck ◽  
B.W. van Dijk ◽  
H. Spekreijse
Keyword(s):  

2006 ◽  
Vol 96 (25) ◽  
Author(s):  
Itai Doron ◽  
Eyal Hulata ◽  
Itay Baruchi ◽  
Vernon L. Towle ◽  
Eshel Ben-Jacob

NeuroImage ◽  
2000 ◽  
Vol 11 (5) ◽  
pp. 359-369 ◽  
Author(s):  
Armin Fuchs ◽  
Viktor K. Jirsa ◽  
J.A.Scott Kelso

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