scholarly journals A simple, reproducible and cost-effective procedure to analyse gut phageome: from phage isolation to bioinformatic approach

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Camille d’Humières ◽  
Marie Touchon ◽  
Sara Dion ◽  
Jean Cury ◽  
Amine Ghozlane ◽  
...  
Keyword(s):  
Cost Effective ◽  
Effective Procedure ◽  
Bioinformatic Approach ◽  
Phage Isolation

Total Synthesis of (+)-Granatumine A and Related Bislactone Limonoid Alkaloids via a Pyran to Pyridine Interconversion

2019 ◽  
Author(s):  
Timothy Newhouse ◽  
Alexander Schuppe ◽  
Yizhou Zhao ◽  
Yannan Liu
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Knoevenagel Condensation ◽  
Cost Effective ◽  
Effective Procedure ◽  
Direct Transformation ◽  
Structural Revision ◽  
Alpha Beta ◽  
Ptp 1B

We report the first total synthesis of (+)-granatumine A, a limonoid alkaloid with PTP-1B inhibitory activity, in 10 steps. Over the course of this study, two key methodological advances were made: a cost effective procedure for ketone alpha,beta-dehydrogenation using allyl-Pd catalysis, and a Pd-catalyzed protocol to convert epoxyketones to 1,3-diketones. The central tetrasubstituted pyridine is formed by a convergent Knoevenagel condensation and carbonyl-selective electrocyclization cascade, which was followed by a direct transformation of a 2<i>H</i>-pyran to a pyridine. These studies have led to the structural revision of two members of this family.

Facile Access to Triazole-Fused 3,1-Benzoxazines Enabled by Metal-Free Base-Promoted Intramolecular C–O Coupling

Synthesis ◽  
2021 ◽  
Author(s):  
Yury N. Kotovshchikov ◽  
Stepan S. Tatevosyan ◽  
Gennadij V. Latyshev ◽  
Nikolay V. Lukashev ◽  
Irina P. Beletskaya
Keyword(s):  
Transition Metal ◽  
Functional Group ◽  
Cost Effective ◽  
Reductive Cleavage ◽  
Effective Procedure ◽  
Free Base ◽  
Metal Free ◽  
Fused Heterocycles ◽  
Convenient Approach

AbstractA convenient approach to assemble 1,2,3-triazole-fused 4H-3,1-benzoxazines has been developed. Diverse alcohol-tethered 5-iodotriazoles, readily accessible by a modified protocol of Cu-catalyzed (3+2)-cycloaddition, were utilized as precursors of the target fused heterocycles. The intramolecular C–O coupling proceeded efficiently under base-mediated transition-metal-free conditions, furnishing cyclization products in yields up to 96%. Suppression of the competing reductive cleavage of the C–I bond was achieved by the use of Na2CO3 in acetonitrile at 100 °C. This practical and cost-effective procedure features a broad substrate scope and valuable functional group tolerance.

Percutaneous retrogasserian glycerol rhizotomy for trigeminal neuralgia: A simple, safe, cost-effective procedure

2015 ◽  
Vol 63 (6) ◽  
pp. 889 ◽  
Author(s):  
M Kodeeswaran ◽  
VG Ramesh ◽  
N Saravanan ◽  
Reshmi Udesh
Keyword(s):  
Trigeminal Neuralgia ◽  
Cost Effective ◽  
Effective Procedure

Ambulatory Phlebectomy: A Review

2000 ◽  
Vol 17 (1) ◽  
pp. 27-35 ◽  
Author(s):  
Jose Antonio Olivencia
Keyword(s):  
Surgical Treatment ◽  
Return To Work ◽  
Local Anesthesia ◽  
Lower Extremities ◽  
Cost Effective ◽  
Effective Procedure ◽  
Office Setting ◽  
Returning Home

Muller's introduction in 1953 of ambulatory phlebectomy, although initially not appreciated nor readily accepted, revolutionized the surgical treatment of varicosities of the lower extremities forever. However, many years had to pass before this would be reality. This article follows the treatment of incompetent saphenofemoral and saphenopopliteal junctions. Ambulatory phlebectomy is an efficient, efficacious, cosmetically superior, appropriate, and cost-effective procedure for the treatment of the varicosities of the lower extremities. It is performed under local anesthesia in an office setting, with the patient returning home the same day. In many instances, the patient is able to return to work the day following the operation.

The Main Features of the Law Amending the General Administrative Procedure Act

10.4335/32 ◽  
2009 ◽  
Vol 6 (1) ◽  
pp. 71-86
Author(s):  
Tjaša Ivanc
Keyword(s):  
Decision Making ◽  
Key Words ◽  
Cost Effective ◽  
Effective Procedure ◽  
Legal Regulations ◽  
Administrative Procedure ◽  
Electronic Service ◽  
Administrative Procedures ◽  
The Law ◽  
The Right

The Law Amending the General Administrative Procedure Act refers to a variety of provisions. New solutions should contribute to a more rapid, more efficient and more cost-effective procedure. Primarily due to elimination of the inconsistent use of individual provisions in practice, the amending law regulates more definitely the issues of authorising the persons to manage and make decisions at different decision-making levels in administrative procedures in municipalities. The law also develops electronic operations and it especially amends the electronic service provisions. There is a fairly large number of amendments in the Service Chapter. And an important novelty needs to be emphasized. This is the institute of the waiver of the right to appeal which the General Administrative Procedure Act did not know. However, it is well-known in foreign legal regulations and in the Construction Act adopted in our country. KEY WORDS: • administrative procedure • electronic operations • right to appeal

Arthroscopy for mechanical symptoms in osteoarthritis: a cost-effective procedure

2014 ◽  
Vol 23 (12) ◽  
pp. 3545-3549 ◽  
Author(s):  
Jonathan R. B. Hutt ◽  
Johnathan Craik ◽  
Joideep Phadnis ◽  
Andrew G. Cobb
Keyword(s):  
Cost Effective ◽  
Effective Procedure
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